PMID- 38129925
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 2045-8118 (Electronic)
IS  - 2045-8118 (Linking)
VI  - 20
IP  - 1
DP  - 2023 Dec 21
TI  - Imaging the neurovascular unit in health and neurodegeneration: a scoping review 
      of interdependencies between MRI measures.
PG  - 97
LID - 10.1186/s12987-023-00499-0 [doi]
LID - 97
AB  - The neurovascular unit (NVU) is a complex structure that facilitates nutrient 
      delivery and metabolic waste clearance, forms the blood-brain barrier (BBB), and 
      supports fluid homeostasis in the brain. The integrity of NVU subcomponents can 
      be measured in vivo using magnetic resonance imaging (MRI), including 
      quantification of enlarged perivascular spaces (ePVS), BBB permeability, cerebral 
      perfusion and extracellular free water. The breakdown of NVU subparts is 
      individually associated with aging, pathology, and cognition. However, how these 
      subcomponents interact as a system, and how interdependencies are impacted by 
      pathology remains unclear. This systematic scoping review identified 26 studies 
      that investigated the inter-relationships between multiple subcomponents of the 
      NVU in nonclinical and neurodegenerative populations using MRI. A further 112 
      studies investigated associations between the NVU and white matter 
      hyperintensities (WMH). We identify two putative clusters of NVU 
      interdependencies: a 'vascular' cluster comprising BBB permeability, perfusion 
      and basal ganglia ePVS; and a 'fluid' cluster comprising ePVS, free water and 
      WMH. Emerging evidence suggests that subcomponent coupling within these clusters 
      may be differentially related to aging, neurovascular injury or neurodegenerative 
      pathology.
CI  - (c) 2023. The Author(s).
FAU - Rowsthorn, Ella
AU  - Rowsthorn E
AD  - Department of Neuroscience, Central Clinical School, Monash University, 99 
      Commercial Road, Melbourne, VIC, 3004, Australia.
AD  - Turner Institute for Brain and Mental Health & School of Psychological Sciences, 
      Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.
FAU - Pham, William
AU  - Pham W
AD  - Department of Neuroscience, Central Clinical School, Monash University, 99 
      Commercial Road, Melbourne, VIC, 3004, Australia.
FAU - Nazem-Zadeh, Mohammad-Reza
AU  - Nazem-Zadeh MR
AD  - Department of Neuroscience, Central Clinical School, Monash University, 99 
      Commercial Road, Melbourne, VIC, 3004, Australia.
FAU - Law, Meng
AU  - Law M
AD  - Department of Neuroscience, Central Clinical School, Monash University, 99 
      Commercial Road, Melbourne, VIC, 3004, Australia.
AD  - Department of Radiology, Alfred Health, 99 Commercial Road, Melbourne, VIC, 3004, 
      Australia.
AD  - Department of Electrical and Computer Systems Engineering, Monash University, 14 
      Alliance Lane, Clayton, VIC, 3168, Australia.
FAU - Pase, Matthew P
AU  - Pase MP
AD  - Turner Institute for Brain and Mental Health & School of Psychological Sciences, 
      Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.
AD  - Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 
      02115, USA.
FAU - Harding, Ian H
AU  - Harding IH
AD  - Department of Neuroscience, Central Clinical School, Monash University, 99 
      Commercial Road, Melbourne, VIC, 3004, Australia. ian.harding@monash.edu.
AD  - Monash Biomedical Imaging, Monash University, 762-772 Blackburn Road, Clayton, 
      VIC, 3168, Australia. ian.harding@monash.edu.
LA  - eng
GR  - GTN2009264/National Health and Medical Research Council/
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20231221
PL  - England
TA  - Fluids Barriers CNS
JT  - Fluids and barriers of the CNS
JID - 101553157
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - *Magnetic Resonance Imaging
MH  - *Brain/diagnostic imaging/pathology
MH  - Blood-Brain Barrier/diagnostic imaging
MH  - Water
PMC - PMC10734164
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Cerebral blood flow
OT  - Free water
OT  - Glymphatic system
OT  - Magnetic resonance imaging
OT  - Neurodegenerative disease
OT  - Neurovascular unit
OT  - Perivascular space
OT  - White matter hyperintensities
COIS- The authors declare that they have no competing interests.
EDAT- 2023/12/22 06:42
MHDA- 2023/12/25 06:42
PMCR- 2023/12/21
CRDT- 2023/12/22 00:31
PHST- 2023/10/03 00:00 [received]
PHST- 2023/12/05 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/22 06:42 [pubmed]
PHST- 2023/12/22 00:31 [entrez]
PHST- 2023/12/21 00:00 [pmc-release]
AID - 10.1186/s12987-023-00499-0 [pii]
AID - 499 [pii]
AID - 10.1186/s12987-023-00499-0 [doi]
PST - epublish
SO  - Fluids Barriers CNS. 2023 Dec 21;20(1):97. doi: 10.1186/s12987-023-00499-0.