PMID- 38130867
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231223
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 17
DP  - 2023
TI  - Presynaptic GABA(B) receptors inhibit vomeronasal nerve transmission to accessory 
      olfactory bulb mitral cells.
PG  - 1302955
LID - 10.3389/fncel.2023.1302955 [doi]
LID - 1302955
AB  - Vomeronasal sensory neurons (VSNs) recognize pheromonal and kairomonal 
      semiochemicals in the lumen of the vomeronasal organ. VSNs send their axons along 
      the vomeronasal nerve (VN) into multiple glomeruli of the accessory olfactory 
      bulb (AOB) and form glutamatergic synapses with apical dendrites of mitral cells, 
      the projection neurons of the AOB. Juxtaglomerular interneurons release the 
      inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Besides ionotropic GABA 
      receptors, the metabotropic GABA(B) receptor has been shown to modulate synaptic 
      transmission in the main olfactory system. Here we show that GABA(B) receptors 
      are expressed in the AOB and are primarily located at VN terminals. Electrical 
      stimulation of the VN provokes calcium elevations in VSN nerve terminals, and 
      activation of GABA(B) receptors by the agonist baclofen abolishes calcium influx 
      in AOB slice preparations. Patch clamp recordings reveal that synaptic 
      transmission from the VN to mitral cells can be completely suppressed by 
      activation of GABA(B) receptors. A potent GABA(B) receptor antagonist, CGP 52432, 
      reversed the baclofen-induced effects. These results indicate that modulation of 
      VSNs via activation of GABA(B) receptors affects calcium influx and glutamate 
      release at presynaptic terminals and likely balances synaptic transmission at the 
      first synapse of the accessory olfactory system.
CI  - Copyright (c) 2023 Weiss and Zufall.
FAU - Weiss, Jan
AU  - Weiss J
AD  - Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland 
      University, Homburg, Germany.
FAU - Zufall, Frank
AU  - Zufall F
AD  - Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland 
      University, Homburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20231207
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC10733964
OTO - NOTNLM
OT  - GABAB receptor
OT  - accessory olfactory bulb
OT  - olfactory plasticity
OT  - pheromone
OT  - presynapse
OT  - synaptic transmission
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/12/22 06:42
MHDA- 2023/12/22 06:43
PMCR- 2023/01/01
CRDT- 2023/12/22 04:03
PHST- 2023/09/27 00:00 [received]
PHST- 2023/11/08 00:00 [accepted]
PHST- 2023/12/22 06:43 [medline]
PHST- 2023/12/22 06:42 [pubmed]
PHST- 2023/12/22 04:03 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2023.1302955 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2023 Dec 7;17:1302955. doi: 10.3389/fncel.2023.1302955. 
      eCollection 2023.