PMID- 38131519
OWN - NLM
STAT- Publisher
LR  - 20231222
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
DP  - 2023 Dec 22
TI  - Prognostic value of pretreatment indocyanine green angiography in the acute 
      uveitic phase of Vogt-Koyanagi-Harada disease.
LID - 10.1111/aos.16613 [doi]
AB  - PURPOSE: To investigate the prognostic value of pretreatment indocyanine green 
      angiographic (ICGA) features in initial-onset acute uveitis associated with 
      Vogt-Koyanagi-Harada (VKH) disease. METHODS: Retrospective analysis of 84 
      patients (168 eyes). Main outcome measures were final visual acuity, development 
      of 'sunset glow fundus' (SGF) and progression to chronic recurrent evolution. 
      RESULTS: Thirty-eight patients (76 eyes) presented in the phase preceding 
      anterior segment (AS) inflammation (early presentation) and 46 patients (92 eyes) 
      had AS inflammation at presentation (late presentation). The mean number of 
      hypofluorescent dark dots (HDDs) and frequency of disc hyperfluorescence were 
      more in the late presentation group (p < 0.001 for both comparisons), whereas the 
      early presentation group showed higher frequencies of peripapillary punctate 
      choroidal hyperfluorescence (p < 0.001) and hypofluorescent patches involving 
      macula corresponding to the areas of exudative retinal detachment (p = 0.012). 
      The mean number of HDDs and the frequency of disc hyperfluorescence were higher 
      among eyes that developed SGF (p < 0.001 for both comparisons) and eyes that 
      progressed to chronic recurrent evolution (p < 0.001; p = 0.001, respectively). 
      The frequencies of peripapillary punctate choroidal hyperfluorescence and 
      hypofluorescent patches corresponding to the areas of exudative retinal 
      detachment were less in the eyes that developed SGF (p = 0.019; p = 0.003, 
      respectively). Punctate choroidal hyperfluorescence elsewhere was less frequent 
      in the eyes that developed SGF (p < 0.001) and eyes that progressed to chronic 
      recurrent evolution (p = 0.002). CONCLUSIONS: Pretreatment ICGA has a prognostic 
      value in initial-onset acute uveitis associated with VKH disease.
CI  - (c) 2023 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Tobaigy, Mohannad F
AU  - Tobaigy MF
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Abouammoh, Marwan A
AU  - Abouammoh MA
AUID- ORCID: 0000-0002-0020-8069
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - AlBloushi, Abdulrahman F
AU  - AlBloushi AF
AUID- ORCID: 0000-0003-1104-9208
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Saifaldein, Amjad Ameen
AU  - Saifaldein AA
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Gikandi, Priscilla
AU  - Gikandi P
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Almousa, Abdullah N
AU  - Almousa AN
AUID- ORCID: 0000-0003-1333-4133
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Herbort, Carl P Jr
AU  - Herbort CP Jr
AD  - Infammatory and Retinal Eye Diseases, Center for Ophthalmic Specialised Care 
      (COS), Lausanne, Switzerland.
FAU - El-Asrar, Ahmed Abu
AU  - El-Asrar AA
AUID- ORCID: 0000-0003-2226-8617
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
AD  - Dr. Nasser Al-Rashid Research Chair in Ophthalmology, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia.
LA  - eng
GR  - IFKSURC-1-2103/Deputyship for Research & Innovation, Ministry of Education in 
      Saudi Arabia/
PT  - Journal Article
DEP - 20231222
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
OTO - NOTNLM
OT  - Vogt-Koyanagi-Harada disease
OT  - chronic recurrent evolution
OT  - indocyanine green angiography
OT  - prognosis
OT  - uveitis
OT  - 'sunset glow fundus'
EDAT- 2023/12/22 12:41
MHDA- 2023/12/22 12:41
CRDT- 2023/12/22 07:51
PHST- 2023/11/16 00:00 [revised]
PHST- 2023/06/22 00:00 [received]
PHST- 2023/12/08 00:00 [accepted]
PHST- 2023/12/22 12:41 [medline]
PHST- 2023/12/22 12:41 [pubmed]
PHST- 2023/12/22 07:51 [entrez]
AID - 10.1111/aos.16613 [doi]
PST - aheadofprint
SO  - Acta Ophthalmol. 2023 Dec 22. doi: 10.1111/aos.16613.