PMID- 38131579
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240207
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 72
IP  - 1
DP  - 2024 Jan 1
TI  - Keratoconus in India: Clinical presentation and demographic distribution based on 
      big data analytics.
PG  - 105-110
LID - 10.4103/IJO.IJO_1190_23 [doi]
AB  - PURPOSE: This paper aims to describe the clinical presentation and demographic 
      distribution of keratoconus (KCN) in India by analyzing the electronic medical 
      records (EMR) of patients presenting at a multitier ophthalmology hospital 
      network. METHODS: This cross-sectional hospital-based study included the data of 
      2,384,523 patients presenting between January 2012 and March 2020. Data were 
      collected from an EMR system. Patients with a clinical diagnosis of KCN in at 
      least one eye were included in this study. Univariate analysis was performed to 
      identify the prevalence of KCN. A multiple logistic regression analysis was 
      performed using R software (version 3.5.1), and the odds ratios are reported. 
      RESULTS: Data were obtained for 14,749 (0.62%) patients with 27,703 eyes 
      diagnosed with KCN and used for the analysis. The median age of the patients was 
      22 (inter-quartile range (IQR): 17-27). In total, 76.64% of adults (odds ratio = 
      8.77; P = <0.001) were affected the most. The majority of patients were male 
      (61.25%), and bilateral (87.83%) affliction was the most common presentation. A 
      significant proportion of the patients were students (63.98%). Most eyes had mild 
      or no visual impairment (<20/70; 61.42%). Corneal signs included ectasia 
      (41.35%), Fleischer ring (44.52%), prominent corneal nerves (45.75%), corneal 
      scarring (13.60%), Vogts striae (18.97%), and hydrops (0.71%). Only 7.85% showed 
      an association with allergic conjunctivitis. A contact lens clinic assessment was 
      administered to 47.87% of patients. Overall, 10.23% of the eyes affected with KCN 
      underwent a surgical procedure. the most common surgery was collagen 
      cross-linking (8.05%), followed by deep anterior lamellar keratoplasty (1.13%) 
      and penetrating keratoplasty (0.88%). CONCLUSION: KCN is usually bilateral and 
      predominantly affects males. It commonly presents in the second and third decade 
      of life, and only a tenth of the affected eyes require surgical treatment.
CI  - Copyright (c) 2023 Copyright: (c) 2023 Indian Journal of Ophthalmology.
FAU - Das, Anthony V
AU  - Das AV
AD  - Department of EMR and AEye, L V Prasad Eye Institute, Hyderabad, Telangana, 
      India.
FAU - Deshmukh, Rashmi S
AU  - Deshmukh RS
AD  - Refractive Surgery and Cataract Service, L V Prasad Eye Institute, Hyderabad, 
      Telangana, India.
FAU - Reddy, Jagadesh C
AU  - Reddy JC
AD  - Refractive Surgery and Cataract Service, L V Prasad Eye Institute, Hyderabad, 
      Telangana, India.
FAU - Joshi, Vineet P
AU  - Joshi VP
AD  - Shantilal Sanghvi Cornea Institute, Hyderabad, Telangana, India.
FAU - Singh, Vivek M
AU  - Singh VM
AD  - Refractive Surgery and Cataract Service, L V Prasad Eye Institute, Hyderabad, 
      Telangana, India.
FAU - Gogri, Pratik Y
AU  - Gogri PY
AD  - Refractive Surgery and Cataract Service, L V Prasad Eye Institute, Hyderabad, 
      Telangana, India.
FAU - Murthy, Somasheila I
AU  - Murthy SI
AD  - Refractive Surgery and Cataract Service, L V Prasad Eye Institute, Hyderabad, 
      Telangana, India.
AD  - Shantilal Sanghvi Cornea Institute, Hyderabad, Telangana, India.
FAU - Chaurasia, Sunita
AU  - Chaurasia S
AD  - Refractive Surgery and Cataract Service, L V Prasad Eye Institute, Hyderabad, 
      Telangana, India.
AD  - Shantilal Sanghvi Cornea Institute, Hyderabad, Telangana, India.
FAU - Fernandes, Merle
AU  - Fernandes M
AD  - Shantilal Sanghvi Cornea Institute, Hyderabad, Telangana, India.
FAU - Roy, Aravind
AU  - Roy A
AD  - Shantilal Sanghvi Cornea Institute, Hyderabad, Telangana, India.
FAU - Das, Sujata
AU  - Das S
AD  - Shantilal Sanghvi Cornea Institute, Hyderabad, Telangana, India.
FAU - Vaddavalli, Pravin K
AU  - Vaddavalli PK
AD  - Refractive Surgery and Cataract Service, L V Prasad Eye Institute, Hyderabad, 
      Telangana, India.
AD  - Shantilal Sanghvi Cornea Institute, Hyderabad, Telangana, India.
LA  - eng
PT  - Journal Article
DEP - 20231222
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Adult
MH  - Humans
MH  - Male
MH  - Female
MH  - *Keratoconus/diagnosis/epidemiology/drug therapy
MH  - Cross-Sectional Studies
MH  - Data Science
MH  - Visual Acuity
MH  - India/epidemiology
MH  - Prevalence
MH  - Retrospective Studies
PMC - PMC10841786
COIS- There are no conflicts of interest.
EDAT- 2023/12/22 12:42
MHDA- 2023/12/25 06:43
PMCR- 2024/01/01
CRDT- 2023/12/22 07:53
PHST- 2023/05/07 00:00 [received]
PHST- 2023/07/13 00:00 [accepted]
PHST- 2023/12/25 06:43 [medline]
PHST- 2023/12/22 12:42 [pubmed]
PHST- 2023/12/22 07:53 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 02223307-202472010-00020 [pii]
AID - IJO-72-105 [pii]
AID - 10.4103/IJO.IJO_1190_23 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2024 Jan 1;72(1):105-110. doi: 10.4103/IJO.IJO_1190_23. Epub 
      2023 Dec 22.