PMID- 38132247
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231224
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 24
DP  - 2023 Dec 14
TI  - Rare Pancreatic/Peripancreatic Cystic Lesions Can Be Accurately Characterized by 
      EUS with Through-the-Needle Biopsy-A Unique Pictorial Essay with Clinical and 
      Histopathological Correlations.
LID - 10.3390/diagnostics13243663 [doi]
LID - 3663
AB  - Due to their aspecific macroscopic appearance, uncommon pancreatic cystic lesions 
      (PCLs) are often misdiagnosed as mucinous lesions and improperly resected. We 
      aimed to evaluate the endoscopic ultrasound (EUS)-guided through-the-needle 
      biopsy (TTNB) capacity of the preoperative diagnosis of uncommon PCLs. Overall, 
      136 patients with PCLs who underwent EUS-TTNB between 2016 and 2022 were 
      retrospectively identified. Common histotypes (e.g., IPMN, serous cystadenoma, 
      and mucinous cystadenoma) were excluded and 26 (19.1%) patients (15 female, mean 
      age 52.9 +/- 10.4) were analyzed. The EUS findings, adverse events (AEs), and TTNB 
      outcomes in uncommon PCLs were evaluated. The cysts histotype was accurately 
      diagnosed by TTNB in 24/26 (92.3%) cases (seven cystic neuroendocrine tumors, 
      four squamoid cysts, three acinar cells cystadenomas, two lymphoepithelial cysts, 
      two mucinous non-neoplastic cysts, two bronchogenic cysts, two cystic 
      lymphangiomas, one solid-pseudopapillary neoplasm, and one schwannoma). In the 
      remaining two cases, lymphangioma was eventually diagnosed after resection. 
      Surgery was performed in 15/26 (57.7%) patients. The mean follow-up of 
      non-surgical patients was 32.5 months. One severe acute case of pancreatitis 
      (3.8%) that required surgery occurred after EUS-TTNB. Uncommon 
      pancreatic/peripancreatic lesions represent the 19.1% of PCLs in our series, with 
      mainly benign histotypes. TTNB demonstrated a high diagnostic performance with a 
      low rate of AEs in this setting, representing a reliable tool with which to avoid 
      useless surgery.
FAU - Conti Bellocchi, Maria Cristina
AU  - Conti Bellocchi MC
AUID- ORCID: 0000-0002-7813-1583
AD  - Diagnostic and Interventional Endoscopy of Pancreas, Pancreas Institute, 
      University of Verona, 37134 Verona, Italy.
FAU - Manfrin, Erminia
AU  - Manfrin E
AD  - Department of Diagnostics and Public Health, Section of Pathology, University of 
      Verona, 37134 Verona, Italy.
FAU - Brillo, Alessandro
AU  - Brillo A
AD  - Diagnostic and Interventional Endoscopy of Pancreas, Pancreas Institute, 
      University of Verona, 37134 Verona, Italy.
FAU - Bernardoni, Laura
AU  - Bernardoni L
AD  - Diagnostic and Interventional Endoscopy of Pancreas, Pancreas Institute, 
      University of Verona, 37134 Verona, Italy.
FAU - Lisotti, Andrea
AU  - Lisotti A
AUID- ORCID: 0000-0002-7724-7402
AD  - Gastrointestinal Unit, Department of Medical and Surgical Sciences, Hospital of 
      Imola, University of Bologna, 40026 Imola, Italy.
FAU - Fusaroli, Pietro
AU  - Fusaroli P
AD  - Gastrointestinal Unit, Department of Medical and Surgical Sciences, Hospital of 
      Imola, University of Bologna, 40026 Imola, Italy.
FAU - Parisi, Alice
AU  - Parisi A
AD  - Department of Pathology and Diagnostics, University Hospital of Verona, 37126 
      Verona, Italy.
FAU - Sina, Sokol
AU  - Sina S
AD  - Department of Pathology and Diagnostics, University Hospital of Verona, 37126 
      Verona, Italy.
FAU - Facciorusso, Antonio
AU  - Facciorusso A
AUID- ORCID: 0000-0002-2107-2156
AD  - Gastroenterology Unit, Department of Medical Sciences, University of Foggia, 
      00161 Foggia, Italy.
FAU - Gabbrielli, Armando
AU  - Gabbrielli A
AD  - Diagnostic and Interventional Endoscopy of Pancreas, Pancreas Institute, 
      University of Verona, 37134 Verona, Italy.
FAU - Crino, Stefano Francesco
AU  - Crino SF
AUID- ORCID: 0000-0003-4560-8741
AD  - Diagnostic and Interventional Endoscopy of Pancreas, Pancreas Institute, 
      University of Verona, 37134 Verona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20231214
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10743172
OTO - NOTNLM
OT  - endoscopic ultrasound
OT  - fine-needle aspiration
OT  - pancreatic cancer
OT  - pancreatic cyst
OT  - pancreatic surgery
OT  - through-the-needle biopsy
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/22 12:43
MHDA- 2023/12/22 12:44
PMCR- 2023/12/14
CRDT- 2023/12/22 09:03
PHST- 2023/11/06 00:00 [received]
PHST- 2023/12/08 00:00 [revised]
PHST- 2023/12/11 00:00 [accepted]
PHST- 2023/12/22 12:44 [medline]
PHST- 2023/12/22 12:43 [pubmed]
PHST- 2023/12/22 09:03 [entrez]
PHST- 2023/12/14 00:00 [pmc-release]
AID - diagnostics13243663 [pii]
AID - diagnostics-13-03663 [pii]
AID - 10.3390/diagnostics13243663 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Dec 14;13(24):3663. doi: 10.3390/diagnostics13243663.