PMID- 38134591
OWN - NLM
STAT- MEDLINE
DCOM- 20240219
LR  - 20240219
IS  - 1879-3320 (Electronic)
IS  - 0960-7404 (Linking)
VI  - 52
DP  - 2024 Feb
TI  - Predictors for quality of life, pain and functional outcomes after surgical 
      treatment of metastatic disease in the spine.
PG  - 102029
LID - S0960-7404(23)00129-9 [pii]
LID - 10.1016/j.suronc.2023.102029 [doi]
AB  - BACKGROUND: While predictors for postoperative survival in spine tumour patients 
      have been identified, there is limited evidence for predictors of postoperative 
      Quality of Life (QoL), pain and functional outcome. METHODS: One hundred and 
      fifty-three consecutive patients, who had undergone surgery for symptomatic 
      spinal metastases between June 2016 and April 2019, were interviewed 
      preoperatively and during follow-ups at three, six and 12 months using the 
      EQ-5D-3L, COMI, and ODI questionnaires. Differences in means exceeding the 
      specific Minimal Clinically Important Difference (MCID) values were considered 
      clinically significant. RESULTS: Thirty-three percent of the patients were 
      reported dead after 12 months. Only one metastasis compared to multiple 
      metastases has 7.9 the Odds for an improved EQ-5D-3L score at three months. No 
      neoadjuvant metastatic irradiation has 6.8 the Odds for the improvement at that 
      time against performed radiation. A preoperative ODI score between 50.1 and 100 
      has 22.0 times the odds compared to the range from 0 to 50 for an improved 
      EQ-5D-3L after three months, and 12.5 times the odds in favour of improved COMI 
      after three months, and 13.6 times the odds for improvement of ODI at the 
      three-month follow-up. A preoperative COMI score ranging from 5.0 to 10 has 21 
      times the odds of a COMI between 0 and 5 for an improved EQ-5D-3L score and 11 
      times the odds for an improved ODI after 12 months. Other predictors showed no 
      statistically significant improvement. CONCLUSION: An improvement in QoL, pain 
      and spinal function after 12 months can be predicted by a subjective preoperative 
      poor health condition. Impaired spinal function before surgery, a singular 
      metastasis and no previous irradiation is predictive of improved spinal function 
      and quality of life three months after surgery.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Walter, Sebastian G
AU  - Walter SG
AD  - University Hospital Cologne, Department of Orthopedic Surgery and Traumatology, 
      Cologne, Germany. Electronic address: Sebastian.walter@uk-koeln.de.
FAU - Hockmann, Jan
AU  - Hockmann J
AD  - University Hospital Cologne, Department of Orthopedic Surgery and Traumatology, 
      Cologne, Germany.
FAU - Weber, Maximilian
AU  - Weber M
AD  - University Hospital Cologne, Department of Orthopedic Surgery and Traumatology, 
      Cologne, Germany.
FAU - Kernich, Nikolaus
AU  - Kernich N
AD  - University Hospital Cologne, Department of Orthopedic Surgery and Traumatology, 
      Cologne, Germany.
FAU - Knoll, Peter
AU  - Knoll P
AD  - University Hospital Cologne, Department of Orthopedic Surgery and Traumatology, 
      Cologne, Germany.
FAU - Zarghooni, Kourosh
AU  - Zarghooni K
AD  - University Hospital Cologne, Department of Orthopedic Surgery and Traumatology, 
      Cologne, Germany.
LA  - eng
PT  - Journal Article
DEP - 20231216
PL  - Netherlands
TA  - Surg Oncol
JT  - Surgical oncology
JID - 9208188
SB  - IM
MH  - Humans
MH  - *Quality of Life
MH  - Treatment Outcome
MH  - *Neoplasms
MH  - Pain, Postoperative
OTO - NOTNLM
OT  - Metastasis
OT  - PROM
OT  - Spine
OT  - Tumour
OT  - Vertebra
COIS- Declaration of competing interest None.
EDAT- 2023/12/22 19:43
MHDA- 2024/02/19 06:43
CRDT- 2023/12/22 18:12
PHST- 2022/09/28 00:00 [received]
PHST- 2023/09/16 00:00 [revised]
PHST- 2023/12/15 00:00 [accepted]
PHST- 2024/02/19 06:43 [medline]
PHST- 2023/12/22 19:43 [pubmed]
PHST- 2023/12/22 18:12 [entrez]
AID - S0960-7404(23)00129-9 [pii]
AID - 10.1016/j.suronc.2023.102029 [doi]
PST - ppublish
SO  - Surg Oncol. 2024 Feb;52:102029. doi: 10.1016/j.suronc.2023.102029. Epub 2023 Dec 
      16.