PMID- 38134642
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240202
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 270
DP  - 2024 Jan 15
TI  - Serum albumin mediates the associations between heavy metals and two novel 
      systemic inflammation indexes among U.S. adults.
PG  - 115863
LID - S0147-6513(23)01367-2 [pii]
LID - 10.1016/j.ecoenv.2023.115863 [doi]
AB  - BACKGROUND: The effects of heavy metal exposure on immunological function have 
      sparked widespread concern, but unequivocal evidence on the association between 
      mixed metal exposure and novel systemic inflammatory indexes remains scarce. 
      OBJECTIVES: This study aimed to analyze the associations of heavy metals with two 
      novel systemic inflammation indexes and the mediated effects of serum albumin. 
      METHODS: Nineteen metals were detected among 4082 U.S. adults based on the 
      NHANES. A linear regression, restricted cubic splines (RCS) regression, weighted 
      quantile sum (WQS), Quantile-based Gcomputation (qgcomp), and Bayesian kernel 
      machine regression (BKMR) were conducted to evaluate the associations of single 
      metal and mixed metals with systemic immune-inflammation index (SII) and systemic 
      inflammation response index (SIRI) levels, respectively. A series of subgroup 
      analyses were used to identify potentially vulnerable populations. Furthermore, 
      we conducted mediation analyses to investigate the mediated effects of serum 
      albumin on the associations of metals with SII and SIRI. RESULTS: In the 
      single-exposure model, exposure to various metals such as urinary Co, As, and 
      serum Zn, Cu was associated with SII and SIRI (P(FDR)<0.05). Simultaneously, the 
      above metals were linear positively correlated with SII and SIRI. Mixed-exposure 
      analyses consistently showed that overall mixed urinary metal levels were 
      positively pertinent for SII and SIRI levels, and the metal Co played a 
      significant role in the urinary metal mixtures. Subgroup analyses showed that 
      exposure to urinary Cd in men and elderly people increased SII and SIRI levels. 
      The results of mediation analyses suggested the association of urinary metal 
      mixture with SII and SIRI was mediated by albumin, and the proportion of 
      mediation was 14.45% and 9.49%, respectively. CONCLUSIONS: Our findings suggested 
      that metal exposure is strongly associated with the levels of system inflammation 
      indexes and that serum albumin is, in part, a mediator of this association.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - He, Yi-Sheng
AU  - He YS
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - Cao, Fan
AU  - Cao F
AD  - Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical 
      University, 678, Furong Road, Hefei, Anhui, China; Department of clinical 
      medicine, The Second School of Clinical Medicine, Anhui Medical University, 81 
      Meishan Road, Hefei, Anhui, China; Beijing Institute of Ophthalmology, Beijing 
      Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 
      Ophthalmology & Visual Sciences Key Laboratory, Beijing, China.
FAU - Musonye, Harry Asena
AU  - Musonye HA
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - Xu, Yi-Qing
AU  - Xu YQ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - Gao, Zhao-Xing
AU  - Gao ZX
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - Ge, Man
AU  - Ge M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - He, Tian
AU  - He T
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - Zhao, Chan-Na
AU  - Zhao CN
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical 
      University, 81 Meishan Road, Hefei 230016 Anhui, China. Electronic address: 
      wangpeng19910318@sina.com.
FAU - Pan, Hai-Feng
AU  - Pan HF
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei 230032, Anhui, China; Institute of 
      Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Hospital, 
      of Anhui Medical University, China; Anhui Provincial Institute of Translational 
      Medicine, China. Electronic address: panhaifeng1982@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20231221
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Serum Albumin)
RN  - 0 (Metals, Heavy)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Male
MH  - Humans
MH  - *Serum Albumin
MH  - Bayes Theorem
MH  - Nutrition Surveys
MH  - *Metals, Heavy/toxicity
MH  - Inflammation/chemically induced
OTO - NOTNLM
OT  - Combined effect
OT  - Mediation
OT  - Metals
OT  - System inflammation indexes
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/22 19:43
MHDA- 2024/01/23 06:44
CRDT- 2023/12/22 18:15
PHST- 2023/10/21 00:00 [received]
PHST- 2023/12/13 00:00 [revised]
PHST- 2023/12/17 00:00 [accepted]
PHST- 2024/01/23 06:44 [medline]
PHST- 2023/12/22 19:43 [pubmed]
PHST- 2023/12/22 18:15 [entrez]
AID - S0147-6513(23)01367-2 [pii]
AID - 10.1016/j.ecoenv.2023.115863 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2024 Jan 15;270:115863. doi: 
      10.1016/j.ecoenv.2023.115863. Epub 2023 Dec 21.