PMID- 38135079
OWN - NLM
STAT- MEDLINE
DCOM- 20240118
LR  - 20240118
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 912
DP  - 2024 Feb 20
TI  - Prenatal exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts the 
      maternal gut microbiome and fecal metabolome homeostasis.
PG  - 169330
LID - S0048-9697(23)07960-3 [pii]
LID - 10.1016/j.scitotenv.2023.169330 [doi]
AB  - Initially considered a "safe" substitute for perfluorooctanoic acid (PFOA), 
      hexafluoropropylene oxide trimer acid (HFPO-TA) has been extensively used in the 
      production of fluoropolymers for several years, leading to its environmental 
      ubiquity and subsequent discovery of its significant bio-accumulative properties 
      and toxicological effects. However, the specific impact of HFPO-TA on females, 
      particularly those who are pregnant, remains unclear. In the present study, 
      pregnant mice were exposed to 0.63 mg/kg/day HFPO-TA from gestational day (GD) 2 
      to GD 18. We then determined the potential effects of exposure on gut microbiota 
      and fecal metabolites at GD 12 (mid-pregnancy) and GD 18 (late pregnancy). Our 
      results revealed that, in addition to liver damage, HFPO-TA exposure during the 
      specified window altered the structure and function of cecal gut microbiota. 
      Notably, these changes showed the opposite trends at GD 12 and GD 18. 
      Specifically, at GD 12, HFPO-TA exposure primarily resulted in the 
      down-regulation of relative abundances within genera from the Bacteroidetes and 
      Proteobacteria phyla, as well as associated Kyoto Encyclopedia of Genes and 
      Genomes (KEGG) pathways. With extended exposure time, the down-regulated genera 
      within Proteobacteria became significantly up-regulated, accompanied by 
      corresponding up-regulation of human disease- and inflammation-associated 
      pathways, suggesting that HFPO-TA exposure can induce intestinal inflammation and 
      elevate the risk of infection during late pregnancy. Pearson correlation analysis 
      revealed that disturbances in the gut microbiota were accompanied by abnormal 
      fecal metabolite. Additionally, alterations in hormones related to the steroid 
      hormone biosynthesis pathway at both sacrifice time indicated that HFPO-TA 
      exposure might change the steroid hormone level of pregnant mice, but need 
      further study. In conclusion, this study provides new insights into the 
      mechanisms underlying HFPO-TA-induced adverse effects and increases awareness of 
      potential persistent health risks to pregnant females.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Shi, Guohui
AU  - Shi G
AD  - State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of 
      Sciences, Beijing 100101, China.
FAU - Zhu, Bao
AU  - Zhu B
AD  - State Environmental Protection Key Laboratory of Environmental Health Impact 
      Assessment of Emerging Contaminants, School of Environmental Sciences and 
      Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Wu, Qi
AU  - Wu Q
AD  - State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of 
      Sciences, Beijing 100101, China.
FAU - Dai, Jiayin
AU  - Dai J
AD  - State Environmental Protection Key Laboratory of Environmental Health Impact 
      Assessment of Emerging Contaminants, School of Environmental Sciences and 
      Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Sheng, Nan
AU  - Sheng N
AD  - State Environmental Protection Key Laboratory of Environmental Health Impact 
      Assessment of Emerging Contaminants, School of Environmental Sciences and 
      Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic 
      address: shengnan@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231220
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate)
RN  - 0 (Fluorocarbons)
RN  - 0 (Hormones)
RN  - 0 (Steroids)
RN  - 0 (Propionates)
SB  - IM
MH  - Female
MH  - Pregnancy
MH  - Mice
MH  - Animals
MH  - Humans
MH  - *Gastrointestinal Microbiome
MH  - *Prenatal Exposure Delayed Effects
MH  - *Fluorocarbons/toxicity
MH  - Homeostasis
MH  - Metabolome
MH  - Proteobacteria
MH  - Hormones
MH  - Inflammation
MH  - Steroids
MH  - *Propionates
OTO - NOTNLM
OT  - Fecal metabolome
OT  - Gut microbiome
OT  - HFPO-TA
OT  - Pregnancy exposure
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/23 12:42
MHDA- 2024/01/18 06:43
CRDT- 2023/12/22 19:30
PHST- 2023/10/08 00:00 [received]
PHST- 2023/12/09 00:00 [revised]
PHST- 2023/12/11 00:00 [accepted]
PHST- 2024/01/18 06:43 [medline]
PHST- 2023/12/23 12:42 [pubmed]
PHST- 2023/12/22 19:30 [entrez]
AID - S0048-9697(23)07960-3 [pii]
AID - 10.1016/j.scitotenv.2023.169330 [doi]
PST - ppublish
SO  - Sci Total Environ. 2024 Feb 20;912:169330. doi: 10.1016/j.scitotenv.2023.169330. 
      Epub 2023 Dec 20.