PMID- 38135238
OWN - NLM
STAT- MEDLINE
DCOM- 20240422
LR  - 20240422
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 261
DP  - 2024 May
TI  - Features Associated With Vision in Eyes With Subfoveal Fibrosis From Neovascular 
      Age-Related Macular Degeneration.
PG  - 121-131
LID - S0002-9394(23)00518-4 [pii]
LID - 10.1016/j.ajo.2023.12.011 [doi]
AB  - PURPOSE: To report the characteristics and correlation of visual acuity in eyes 
      treated for neovascular age-related macular degeneration (nAMD) and developed 
      fibrosis. DESIGN: Case-control study. METHODS: Three hundred fifty-six 
      treatment-naive nAMD eyes that were treated for 12 months were included. Fibrosis 
      was defined as present if well-defined hyperreflective material (HRM) were 
      present between the neurosensory retina and the Bruch membrane on optical 
      coherence tomography (OCT) that correlated with well-defined regions of yellowish 
      pallor on fundus photography and/or staining on fluorescence angiography. OCT 
      features of subfoveal fibrosis and the overlying retina were correlated with 
      visual acuity at month 12. RESULTS: Sixty-three eyes (20.3%) developed incident 
      fibrosis at month 12. Compared with eyes that did not develop fibrosis, these 
      eyes had lower baseline vision (49 vs 54 letters, P = .02) and more of them had 
      type 2 macular neovascularization (15.0 vs 8.8%, P = .03), larger lesion area 
      (29.6 vs 15.1 mm(2), P = .02), and subretinal hemorrhage >/=4 disc diameters (44.4% 
      vs 19.8%, P < .01). Visual acuity was worse in the incident fibrosis compared 
      with the group that never developed fibrosis by month 12. (-1.4+/-17.1 versus 
      +6.0+/-17.4 letters, P < .01). In 83 eyes that had subfoveal fibrosis, better 
      vision was associated with intact ellipsoid zone-external limiting membrane 
      complex (beta coefficient 29.4, 95% CI 14.2-44.6, P < .01), whereas worse vision was 
      associated with retinal pigment epithelium (RPE)-involving HRM, HRM above the 
      RPE, and width of HRM (beta coefficients -25.4 [95% CI -36.3 to -14.6], P < .01; 
      -23.5 [95% CI -39.0 to -7.9], P < .01; and -3.8 [95% CI -7.2 to -0.4], P = .03, 
      respectively). CONCLUSION: Although fibrosis is associated with poorer visual 
      outcome, preservation of external limiting membrane and level of fibrosis 
      relative to the RPE are associated with visual outcomes.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Teo, Kelvin Y C
AU  - Teo KYC
AD  - From the Singapore Eye Research Institute, Singapore National Eye Centre 
      (K.Y.C.T., J.Z., F.I.I., B.F., C.M.G.C.), Singapore; Duke-NUS Medical School, 
      National University of Singapore (K.Y.C.T., F.I.I., B.F., C.M.G.C.), Singapore.
FAU - Zhao, Jinzhi
AU  - Zhao J
AD  - From the Singapore Eye Research Institute, Singapore National Eye Centre 
      (K.Y.C.T., J.Z., F.I.I., B.F., C.M.G.C.), Singapore.
FAU - Ibrahim, Farah Ilyana
AU  - Ibrahim FI
AD  - From the Singapore Eye Research Institute, Singapore National Eye Centre 
      (K.Y.C.T., J.Z., F.I.I., B.F., C.M.G.C.), Singapore; Duke-NUS Medical School, 
      National University of Singapore (K.Y.C.T., F.I.I., B.F., C.M.G.C.), Singapore.
FAU - Fenner, Beau
AU  - Fenner B
AD  - From the Singapore Eye Research Institute, Singapore National Eye Centre 
      (K.Y.C.T., J.Z., F.I.I., B.F., C.M.G.C.), Singapore; Duke-NUS Medical School, 
      National University of Singapore (K.Y.C.T., F.I.I., B.F., C.M.G.C.), Singapore.
FAU - Chakravarthy, Usha
AU  - Chakravarthy U
AD  - Queens University of Belfast (U.C.), Belfast, Northern Ireland.
FAU - Cheung, Chui Ming Gemmy
AU  - Cheung CMG
AD  - From the Singapore Eye Research Institute, Singapore National Eye Centre 
      (K.Y.C.T., J.Z., F.I.I., B.F., C.M.G.C.), Singapore; Duke-NUS Medical School, 
      National University of Singapore (K.Y.C.T., F.I.I., B.F., C.M.G.C.), Singapore. 
      Electronic address: gemmy.cheung.c.m@singhealth.com.sg.
LA  - eng
PT  - Journal Article
DEP - 20231220
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Humans
MH  - Angiogenesis Inhibitors/therapeutic use
MH  - Case-Control Studies
MH  - Vascular Endothelial Growth Factor A
MH  - Retrospective Studies
MH  - Fibrosis
MH  - Tomography, Optical Coherence/methods
MH  - *Macular Degeneration
MH  - Fluorescein Angiography
MH  - *Wet Macular Degeneration/complications/diagnosis
EDAT- 2023/12/23 12:42
MHDA- 2024/04/22 06:44
CRDT- 2023/12/22 19:34
PHST- 2023/09/24 00:00 [received]
PHST- 2023/12/12 00:00 [revised]
PHST- 2023/12/14 00:00 [accepted]
PHST- 2024/04/22 06:44 [medline]
PHST- 2023/12/23 12:42 [pubmed]
PHST- 2023/12/22 19:34 [entrez]
AID - S0002-9394(23)00518-4 [pii]
AID - 10.1016/j.ajo.2023.12.011 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2024 May;261:121-131. doi: 10.1016/j.ajo.2023.12.011. Epub 2023 
      Dec 20.