PMID- 38136338
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231225
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 24
DP  - 2023 Dec 11
TI  - A Novel LncRNA MASCC1 Regulates the Progression and Metastasis of Head and Neck 
      Squamous Cell Carcinoma by Sponging miR-195.
LID - 10.3390/cancers15245792 [doi]
LID - 5792
AB  - The altered expression of long noncoding RNAs (lncRNAs) is associated with human 
      carcinogenesis. We performed a high-throughput analysis of lncRNA expression in 
      strictly selected pairs of metastatic head and neck squamous cell carcinoma 
      (HNSCC) and non-metastatic HNSCC samples. We identified a novel lncRNA, which was 
      highly expressed in metastatic HNSCC, named Metastasis Associated Squamous Cell 
      Carcinoma 1 (MASCC1), for further study. Using qRT-PCR, we further compared 
      MASCC1 expression in 60 HNSCC samples. The results show that high expression of 
      MASCC1 in patients with HNSCC was related to poor prognosis. In vitro, MASCC1 
      knockdown (KD) inhibited HNSCC proliferation, migration, invasion, and tumor 
      sphere formation, while promoting apoptosis. In vivo, MASCC1 KD inhibited HNSCC 
      growth and lymph node metastasis. Mechanistically, MASCC1 acted as a competing 
      endogenous RNA (ceRNA) by binding to miR-195, subsequently regulating the 
      expression of Cyclin D1, BCL-2, and YAP1. Moreover, miR-195 overexpression 
      rescued the effects of MASCC1 on the biological behaviors of HNSCC. Taken 
      together, our results suggest that MASCC1 is a novel oncogene that can predict 
      the prognosis of patients with HNSCC and is a potential therapeutic target for 
      HNSCC intervention.
FAU - Wang, Yujia
AU  - Wang Y
AUID- ORCID: 0000-0002-7575-9009
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing 100081, China.
FAU - Qin, Zhen
AU  - Qin Z
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing 100081, China.
FAU - Chen, Yiwen
AU  - Chen Y
AUID- ORCID: 0000-0002-1594-8908
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing 100081, China.
FAU - Zheng, Yunfei
AU  - Zheng Y
AD  - Department of Orthodontics, Peking University School and Hospital of Stomatology, 
      Beijing 100081, China.
FAU - Jia, Lingfei
AU  - Jia L
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing 100081, China.
AD  - Department of Central Laboratory, Peking University School and Hospital of 
      Stomatology, Beijing 100081, China.
AD  - National Center of Stomatology & National Clinical Research Center for Oral 
      Diseases & National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing 100081, China.
LA  - eng
GR  - 82272706/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20231211
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10741893
OTO - NOTNLM
OT  - head and neck squamous cell carcinoma (HNSCC)
OT  - lncRNA
OT  - metastasis
OT  - metastasis associated squamous cell carcinoma 1 (MASCC1)
OT  - miR-195
OT  - miRNA
OT  - progression
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:43
MHDA- 2023/12/23 12:44
PMCR- 2023/12/11
CRDT- 2023/12/23 01:03
PHST- 2023/11/12 00:00 [received]
PHST- 2023/12/02 00:00 [revised]
PHST- 2023/12/04 00:00 [accepted]
PHST- 2023/12/23 12:44 [medline]
PHST- 2023/12/23 12:43 [pubmed]
PHST- 2023/12/23 01:03 [entrez]
PHST- 2023/12/11 00:00 [pmc-release]
AID - cancers15245792 [pii]
AID - cancers-15-05792 [pii]
AID - 10.3390/cancers15245792 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Dec 11;15(24):5792. doi: 10.3390/cancers15245792.