PMID- 38136648
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240104
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 12
DP  - 2023 Dec 12
TI  - The Association between Serum 25-Hydroxyvitamin D3 Levels and Pro-Inflammatory 
      Markers in New-Onset Type 2 Diabetes Mellitus and Prediabetes.
LID - 10.3390/biom13121778 [doi]
LID - 1778
AB  - In this study, we aimed to reveal the pro-inflammatory effects of serum 
      25-hydroxyvitamin D3 (Vit D) deficiency and insufficiency in new-onset type 2 
      diabetes mellitus (T2DM) and prediabetes. We recruited 84 prediabetes patients, 
      94 new-onset T2DM patients and 113 healthy participants. We measured the levels 
      of C-reactive protein (CRP), fibrinogen, ferritin, interleukin-1beta (IL-1beta), 
      interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), 
      nuclear factor kappa-B (NF-kappaB) and mitogen-activated protein kinase (MAPK) in the 
      serum of the participants. ANOVA Bonferroni and Kruskal-Wallis Dunn tests were 
      used to compare the inflammation markers and vitamin D levels between the groups. 
      Based on covariance analysis with age, gender and BMI, the Vit D levels of the 
      T2DM group were significantly lower (p < 0.003). Pro-inflammatory markers and CRP 
      were significantly higher in prediabetic and diabetic subjects. In the 
      prediabetes group, IL-1beta, IL-6, IL-8, TNF-alpha and MAPK were significantly higher in 
      those with Vit D insufficiency and deficiency groups. In the T2DM group, IL-1beta, 
      IL-6, IL-8, TNF-alpha, NF-kappaB, MAPK and CRP were significantly higher in those with 
      Vit D insufficiency and deficiency. Our study emphasizes the pro-inflammatory 
      effects of Vit D deficiency and insufficiency in new-onset type 2 diabetes 
      mellitus and prediabetes.
FAU - Fenercioglu, Aysen Kutan
AU  - Fenercioglu AK
AUID- ORCID: 0000-0003-2965-6102
AD  - Department of Family Medicine, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, 34320 Istanbul, Turkey.
FAU - Gonen, Mustafa Sait
AU  - Gonen MS
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34320 Istanbul, 
      Turkey.
FAU - Uzun, Hafize
AU  - Uzun H
AUID- ORCID: 0000-0002-1347-8498
AD  - Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas 
      University, 34403 Istanbul, Turkey.
FAU - Sipahioglu, Nurver Turfaner
AU  - Sipahioglu NT
AD  - Department of Family Medicine, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, 34320 Istanbul, Turkey.
FAU - Can, Gunay
AU  - Can G
AD  - Department of Public Health, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, 34320 Istanbul, Turkey.
FAU - Tas, Ebru
AU  - Tas E
AD  - Department of Family Medicine, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, 34320 Istanbul, Turkey.
AD  - Homecare Unit, Isparta Sehit Yunus Emre State Hospital, 32300 Isparta, Turkey.
FAU - Kara, Zehra
AU  - Kara Z
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34320 Istanbul, 
      Turkey.
FAU - Ozkaya, Hande Mefkure
AU  - Ozkaya HM
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34320 Istanbul, 
      Turkey.
FAU - Atukeren, Pinar
AU  - Atukeren P
AD  - Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul 
      University-Cerrahpasa, 34320 Istanbul, Turkey.
LA  - eng
GR  - BAP, 34373/Istanbul University Cerrahpasa/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231212
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - P6YZ13C99Q (Calcifediol)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 1406-16-2 (Vitamin D)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - 0 (Vitamins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - *Prediabetic State
MH  - Calcifediol
MH  - Interleukin-8
MH  - Tumor Necrosis Factor-alpha
MH  - Interleukin-6
MH  - NF-kappa B
MH  - Vitamin D
MH  - C-Reactive Protein
MH  - Mitogen-Activated Protein Kinases
MH  - Vitamins
PMC - PMC10741791
OTO - NOTNLM
OT  - 25-hydroxyvitamin D3
OT  - MAPK
OT  - NF-kB
OT  - TNF-alpha
OT  - inflammation
OT  - interleukins
OT  - prediabetes
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:44
MHDA- 2023/12/25 06:42
PMCR- 2023/12/12
CRDT- 2023/12/23 01:05
PHST- 2023/10/02 00:00 [received]
PHST- 2023/12/05 00:00 [revised]
PHST- 2023/12/09 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/23 12:44 [pubmed]
PHST- 2023/12/23 01:05 [entrez]
PHST- 2023/12/12 00:00 [pmc-release]
AID - biom13121778 [pii]
AID - biomolecules-13-01778 [pii]
AID - 10.3390/biom13121778 [doi]
PST - epublish
SO  - Biomolecules. 2023 Dec 12;13(12):1778. doi: 10.3390/biom13121778.