PMID- 38136657
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240104
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 12
DP  - 2023 Dec 13
TI  - Role of NMDA Receptor in High-Pressure Neurological Syndrome and Hyperbaric 
      Oxygen Toxicity.
LID - 10.3390/biom13121786 [doi]
LID - 1786
AB  - Professional divers exposed to pressures greater than 11 ATA (1.1 MPa) may suffer 
      from high-pressure neurological syndrome (HPNS). Divers who use closed-circuit 
      breathing apparatus and patients and medical attendants undergoing hyperbaric 
      oxygen therapy (HBOT) face the risk of CNS hyperbaric oxygen toxicity (HBOTx) at 
      oxygen pressure above 2 ATA (0.2 MPa). Both syndromes are characterized by 
      reversible CNS hyperexcitability, accompanied by cognitive and motor deficits, 
      and N-methyl-D-aspartate receptor (NMDAR) plays a crucial role in provoking them. 
      Various NMDAR subtypes respond differently under hyperbaric conditions. The 
      augmented currents observed only in NMDAR containing GluN2A subunit increase 
      glutamatergic synaptic activity and cause dendritic hyperexcitability and 
      abnormal neuronal activity. Removal of the resting Zn(2+) voltage-independent 
      inhibition exerted by GluN2A present in the NMDAR is the major candidate for the 
      mechanism underlying the increase in receptor conductance. Therefore, this 
      process should be the main target for future research aiming at developing 
      neuroprotection against HPNS and HBOTx.
FAU - Bliznyuk, Alice
AU  - Bliznyuk A
AUID- ORCID: 0000-0002-8943-0407
AD  - Ilse Katz Institute for Nanoscale Science and Technology (IKI), Ben-Gurion 
      University of the Negev, Beer Sheva 8410501, Israel.
FAU - Grossman, Yoram
AU  - Grossman Y
AD  - Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, 
      Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 
      8410501, Israel.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231213
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Humans
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - *High Pressure Neurological Syndrome
MH  - *Hyperbaric Oxygenation
MH  - Signal Transduction
MH  - Oxygen
PMC - PMC10742241
OTO - NOTNLM
OT  - GluN2A
OT  - HBOTx
OT  - HPNS
OT  - NMDAR
OT  - Zn2+ voltage-independent inhibition
OT  - high pressure
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:42
MHDA- 2023/12/25 06:41
PMCR- 2023/12/13
CRDT- 2023/12/23 01:05
PHST- 2023/10/27 00:00 [received]
PHST- 2023/11/26 00:00 [revised]
PHST- 2023/12/11 00:00 [accepted]
PHST- 2023/12/25 06:41 [medline]
PHST- 2023/12/23 12:42 [pubmed]
PHST- 2023/12/23 01:05 [entrez]
PHST- 2023/12/13 00:00 [pmc-release]
AID - biom13121786 [pii]
AID - biomolecules-13-01786 [pii]
AID - 10.3390/biom13121786 [doi]
PST - epublish
SO  - Biomolecules. 2023 Dec 13;13(12):1786. doi: 10.3390/biom13121786.