PMID- 38136967
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 14
IP  - 12
DP  - 2023 Nov 27
TI  - Genomics of Shrimp Allergens and Beyond.
LID - 10.3390/genes14122145 [doi]
LID - 2145
AB  - Allergy to shellfishes, including mollusks and crustaceans, is a growing health 
      concern worldwide. Crustacean shellfish is one of the "Big Eight" allergens 
      designated by the U.S. Food and Drug Administration and is the major cause of 
      food-induced anaphylaxis. Shrimp is one of the most consumed crustaceans 
      triggering immunoglobulin E (IgE)-mediated allergic reactions. Over the past 
      decades, the allergen repertoire of shrimp has been unveiled based on 
      conventional immunodetection methods. With the availability of genomic data for 
      penaeid shrimp and other technological advancements like transcriptomic 
      approaches, new shrimp allergens have been identified and directed new insights 
      into their expression levels, cross-reactivity, and functional impact. In this 
      review paper, we summarize the current knowledge on shrimp allergens, as well as 
      allergens from other crustaceans and mollusks. Specific emphasis is put on the 
      genomic information of the shrimp allergens, their protein characteristics, and 
      cross-reactivity among shrimp and other organisms.
FAU - Li, Shanshan
AU  - Li S
AUID- ORCID: 0000-0003-3505-6138
AD  - School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Chu, Ka Hou
AU  - Chu KH
AUID- ORCID: 0000-0001-8107-5415
AD  - School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
AD  - Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), 
      Guangzhou 510000, China.
FAU - Wai, Christine Yee Yan
AU  - Wai CYY
AD  - Department of Paediatrics, Prince of Wales Hospital, The Chinese University of 
      Hong Kong, Hong Kong, China.
AD  - Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong 
      Kong, China.
LA  - eng
GR  - 08191356/Health and Medical Research Fund, Hong Kong SAR Government./
PT  - Journal Article
PT  - Review
DEP - 20231127
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (Allergens)
SB  - IM
MH  - United States
MH  - Animals
MH  - Humans
MH  - Allergens/genetics
MH  - Shellfish
MH  - Mollusca
MH  - *Hypersensitivity
MH  - *Penaeidae/genetics
MH  - Genomics
PMC - PMC10742822
OTO - NOTNLM
OT  - allergen profile
OT  - cross-reactivity
OT  - shellfish allergen
OT  - shrimp genomics
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:43
MHDA- 2023/12/25 06:42
PMCR- 2023/11/27
CRDT- 2023/12/23 01:07
PHST- 2023/10/25 00:00 [received]
PHST- 2023/11/21 00:00 [revised]
PHST- 2023/11/23 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/23 12:43 [pubmed]
PHST- 2023/12/23 01:07 [entrez]
PHST- 2023/11/27 00:00 [pmc-release]
AID - genes14122145 [pii]
AID - genes-14-02145 [pii]
AID - 10.3390/genes14122145 [doi]
PST - epublish
SO  - Genes (Basel). 2023 Nov 27;14(12):2145. doi: 10.3390/genes14122145.