PMID- 38137029
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 14
IP  - 12
DP  - 2023 Dec 13
TI  - Epigenetic Profiling of Type 2 Diabetes Mellitus: An Epigenome-Wide Association 
      Study of DNA Methylation in the Korean Genome and Epidemiology Study.
LID - 10.3390/genes14122207 [doi]
LID - 2207
AB  - Diabetes is characterized by persistently high blood glucose levels and severe 
      complications and affects millions of people worldwide. In this study, we 
      explored the epigenetic landscape of diabetes using data from the Korean Genome 
      and Epidemiology Study (KoGES), specifically the Ansung-Ansan (AS-AS) cohort. 
      Using epigenome-wide association studies, we investigated DNA methylation 
      patterns in patients with type 2 diabetes mellitus (T2DM) and those with normal 
      glucose regulation. Differential methylation analysis revealed 106 differentially 
      methylated probes (DMPs), with the 10 top DMPs prominently associated with TXNIP, 
      PDK4, NBPF20, ARRDC4, UFM1, PFKFB2, C7orf50, and ABCG1, indicating significant 
      changes in methylation. Correlation analysis highlighted the association between 
      the leading DMPs (e.g., cg19693031 and cg26974062 for TXNIP and cg26823705 for 
      NBPF20) and key glycemic markers (fasting plasma glucose and hemoglobin A1c), 
      confirming their relevance in T2DM. Moreover, we identified 62 significantly 
      differentially methylated regions (DMRs) spanning 61 genes. A DMR associated with 
      PDE1C showed hypermethylation, whereas DMRs associated with DIP2C, FLJ90757, 
      PRSS50, and TDRD9 showed hypomethylation. PDE1C and TDRD9 showed a strong 
      positive correlation between the CpG sites included in each DMR, which have 
      previously been implicated in T2DM-related processes. This study contributes to 
      the understanding of epigenetic modifications in T2DM. These valuable insights 
      can be utilized in identifying potential biomarkers and therapeutic targets for 
      effective management and prevention of diabetes.
FAU - Seo, Hyein
AU  - Seo H
AD  - Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Republic of Korea.
FAU - Park, Jae-Ho
AU  - Park JH
AUID- ORCID: 0000-0003-4428-436X
AD  - Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Republic of Korea.
FAU - Hwang, Jin-Taek
AU  - Hwang JT
AD  - Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Republic of Korea.
FAU - Choi, Hyo-Kyoung
AU  - Choi HK
AD  - Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Republic of Korea.
FAU - Park, Soo-Hyun
AU  - Park SH
AUID- ORCID: 0000-0003-0968-558X
AD  - Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Republic of Korea.
FAU - Lee, Jangho
AU  - Lee J
AUID- ORCID: 0000-0002-5604-821X
AD  - Korea Food Research Institute, Wanju-gun 55365, Jeollabuk-do, Republic of Korea.
LA  - eng
GR  - E0210601/Korea Food Research Institute/
GR  - E0210400/Korea Food Research Institute/
PT  - Journal Article
DEP - 20231213
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - EC 2.7.1.105 (PFKFB2 protein, human)
RN  - EC 2.7.1.105 (Phosphofructokinase-2)
SB  - IM
MH  - Humans
MH  - *DNA Methylation/genetics
MH  - Epigenome
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Genome-Wide Association Study
MH  - Epigenesis, Genetic/genetics
MH  - Republic of Korea/epidemiology
MH  - Phosphofructokinase-2/genetics
PMC - PMC10743302
OTO - NOTNLM
OT  - DNA methylation
OT  - EWAS
OT  - KoGES
OT  - epigenetic landscape
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:43
MHDA- 2023/12/25 06:42
PMCR- 2023/12/13
CRDT- 2023/12/23 01:07
PHST- 2023/10/31 00:00 [received]
PHST- 2023/12/08 00:00 [revised]
PHST- 2023/12/12 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/23 12:43 [pubmed]
PHST- 2023/12/23 01:07 [entrez]
PHST- 2023/12/13 00:00 [pmc-release]
AID - genes14122207 [pii]
AID - genes-14-02207 [pii]
AID - 10.3390/genes14122207 [doi]
PST - epublish
SO  - Genes (Basel). 2023 Dec 13;14(12):2207. doi: 10.3390/genes14122207.