PMID- 38137685
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231225
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 24
DP  - 2023 Dec 11
TI  - Evaluating the Minimum Clinically Important Difference and Patient Acceptable 
      Symptom State for the Womac Osteoarthritis Index after Unicompartmental Knee 
      Arthroplasty.
LID - 10.3390/jcm12247618 [doi]
LID - 7618
AB  - Patient-Reported Outcome Measures (PROMs) are standardized questionnaires that 
      gather information on health-related quality of life directly from patients. 
      Since a significant statistical mean change may not correspond to a clinical 
      improvement, there is a need to calculate a considerable change in scores. This 
      is done by the Minimum Clinically Important Difference (MCID) and Patient 
      Acceptable Symptom State (PASS). The objective of this article is to report the 
      MCID and the PASS values of the WOMAC (Western Ontario and McMaster University) 
      osteoarthritis index for patients undergoing Unicompartmental Knee Arthroplasty 
      (UKA). A total of 37 patients (25 females and 12 males; mean age 68 +/- 8.1 years 
      and mean BMI 28.7 +/- 4) who underwent UKA were enrolled. All patients were 
      assessed using the WOMAC and the Oxford Knee Score (OKS) questionnaires before 
      and six months following the procedure. To measure the cut-off values for MCID, 
      distribution methods and anchor methods were applied, while the PASS was assessed 
      only via anchor approaches. The MCID related to the WOMAC average global score 
      was 90.7 +/- 7.6, the average pain dimension score was 93.2 +/- 6.6, the average 
      stiffness dimension score was 92.6 +/- 17, and the average physical function 
      dimension score was 89.7 +/- 7.6. In terms of PASS, the normalized WOMAC was 82.8, 
      the pain dimension was 87.5, the stiffness dimension was 93.7, and the functional 
      dimension was 83.1. A 34.5 amelioration in the WOMAC score, from initial 
      evaluation to final follow-up, using change in OKS > 5 as anchor, indicates that 
      the patients' health state improved to a clinically significant degree. A value 
      at least of 82.8 in WOMAC score after treatment denotes that the symptom state is 
      deemed acceptable by most of the patients.
FAU - Longo, Umile Giuseppe
AU  - Longo UG
AUID- ORCID: 0000-0003-4063-9821
AD  - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 
      200, 00128 Roma, Italy.
AD  - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and 
      Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 
      Roma, Italy.
FAU - Papalia, Rocco
AU  - Papalia R
AD  - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 
      200, 00128 Roma, Italy.
AD  - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and 
      Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 
      Roma, Italy.
FAU - Campi, Stefano
AU  - Campi S
AD  - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 
      200, 00128 Roma, Italy.
AD  - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and 
      Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 
      Roma, Italy.
FAU - De Salvatore, Sergio
AU  - De Salvatore S
AUID- ORCID: 0000-0002-9111-3638
AD  - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 
      200, 00128 Roma, Italy.
AD  - Research Unit of Ospedale Pediatrico Bambin Gesu, Dipartimento di Medicina e 
      Chirurgia, Via della Torre di Palidoro, 00050 Fiumicino, Italy.
FAU - Piergentili, Ilaria
AU  - Piergentili I
AD  - Consiglio Nazionale delle Ricerche-Istituto di Analisi dei Sistemi ed Informatica 
      CNR-IASI, Laboratorio di Biomatematica, 00185 Roma, Italy.
FAU - Bandini, Benedetta
AU  - Bandini B
AUID- ORCID: 0000-0001-5909-3887
AD  - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 
      200, 00128 Roma, Italy.
AD  - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and 
      Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 
      Roma, Italy.
FAU - Lalli, Alberto
AU  - Lalli A
AUID- ORCID: 0000-0001-8043-1705
AD  - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 
      200, 00128 Roma, Italy.
AD  - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and 
      Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 
      Roma, Italy.
FAU - Denaro, Vincenzo
AU  - Denaro V
AD  - Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 
      200, 00128 Roma, Italy.
AD  - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and 
      Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 
      Roma, Italy.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10744230
OTO - NOTNLM
OT  - MCID
OT  - OKS
OT  - PASS
OT  - PROM
OT  - UKA
OT  - WOMAC osteoarthritis index
COIS- Umile Giuseppe Longo is a guest Editor of the special issue of Journal of 
      Clinical Medicine. The rest of the authors declare that they have no conflict of 
      interest.
EDAT- 2023/12/23 12:43
MHDA- 2023/12/23 12:44
PMCR- 2023/12/11
CRDT- 2023/12/23 01:11
PHST- 2023/10/13 00:00 [received]
PHST- 2023/11/26 00:00 [revised]
PHST- 2023/12/01 00:00 [accepted]
PHST- 2023/12/23 12:44 [medline]
PHST- 2023/12/23 12:43 [pubmed]
PHST- 2023/12/23 01:11 [entrez]
PHST- 2023/12/11 00:00 [pmc-release]
AID - jcm12247618 [pii]
AID - jcm-12-07618 [pii]
AID - 10.3390/jcm12247618 [doi]
PST - epublish
SO  - J Clin Med. 2023 Dec 11;12(24):7618. doi: 10.3390/jcm12247618.