PMID- 38138213
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 12
DP  - 2023 Dec 1
TI  - The Management and Diagnosis of Anti-NMDA Receptor Autoimmune Encephalitis in 
      Pregnant Women: A Case Report and Literature Review.
LID - 10.3390/medicina59122110 [doi]
LID - 2110
AB  - Rationale: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a form of 
      autoimmune synaptic encephalitis, often mediated by neuronal surface antibodies. 
      Clinically, it manifests through a diverse range of neurological and psychiatric 
      symptoms, primarily affecting young women with ovarian teratoma, which is rare in 
      pregnant women. Patient concerns: We report a case of a 35-year-old multiparous 
      pregnant patient at 38 weeks of gestation presented to the emergency room with 
      seizure, psychiatric symptoms like delirious speech with mystical visual and 
      auditory hallucinations, bradylalia, and retrograde amnesia. Diagnosis: The 
      diagnosis of autoimmune encephalitis with anti-NMDA antibodies was concluded by 
      considering the lumbar puncture results, brain imaging, and the patient's 
      persistent symptoms. Outcomes: This case is noteworthy for its rarity and the 
      symptoms' breadth. At 38 weeks of gestation, the patient underwent a cesarean 
      section, resulting in excellent maternal recovery observed during the 6-month 
      follow-up and good neonatal adaptation. Lessons: Our goals include raising 
      awareness about this condition and emphasizing the significance of early 
      diagnosis. This encephalitis is treatable and potentially reversible, 
      underscoring the importance of prompt identification.
FAU - Potorac, Alina
AU  - Potorac A
AD  - Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 050474 
      Bucharest, Romania.
FAU - Varlas, Valentin Nicolae
AU  - Varlas VN
AUID- ORCID: 0000-0002-8342-9819
AD  - Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine 
      and Pharmacy, 050474 Bucharest, Romania.
AD  - Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, 011132 
      Bucharest, Romania.
FAU - Bors, Roxana Georgiana
AU  - Bors RG
AD  - Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 050474 
      Bucharest, Romania.
FAU - Baros, Alexandru
AU  - Baros A
AD  - Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine 
      and Pharmacy, 050474 Bucharest, Romania.
AD  - Department of Obstetrics and Gynecology, University Emergency Hospital, 050098 
      Bucharest, Romania.
FAU - Cirstoiu, Monica
AU  - Cirstoiu M
AD  - Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine 
      and Pharmacy, 050474 Bucharest, Romania.
AD  - Department of Obstetrics and Gynecology, University Emergency Hospital, 050098 
      Bucharest, Romania.
LA  - eng
PT  - Case Reports
PT  - Review
DEP - 20231201
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Infant, Newborn
MH  - Female
MH  - Pregnancy
MH  - Humans
MH  - Adult
MH  - Pregnant Women
MH  - Cesarean Section
MH  - Receptors, N-Methyl-D-Aspartate
MH  - *Ovarian Neoplasms
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis
PMC - PMC10744478
OTO - NOTNLM
OT  - anti-NMDAR autoimmune encephalitis
OT  - cesarean section
OT  - excellent maternal recovery
OT  - gestation
OT  - hallucinations
OT  - psychiatric symptoms
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:43
MHDA- 2023/12/25 06:42
PMCR- 2023/12/01
CRDT- 2023/12/23 01:14
PHST- 2023/10/25 00:00 [received]
PHST- 2023/11/23 00:00 [revised]
PHST- 2023/11/27 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/23 12:43 [pubmed]
PHST- 2023/12/23 01:14 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - medicina59122110 [pii]
AID - medicina-59-02110 [pii]
AID - 10.3390/medicina59122110 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Dec 1;59(12):2110. doi: 10.3390/medicina59122110.