PMID- 38138293
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 12
DP  - 2023 Dec 17
TI  - Exploring the Multifaceted Potential of Sildenafil in Medicine.
LID - 10.3390/medicina59122190 [doi]
LID - 2190
AB  - Phosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating 
      cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation 
      and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained 
      vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation 
      linked to various pathologies, including cancer and neurodegenerative diseases. 
      Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction 
      and pulmonary arterial hypertension. However, considering the extensive roles of 
      PDE5, sildenafil might be useful in other pathologies. This review aims to 
      comprehensively explore sildenafil's therapeutic potential across medicine, 
      addressing a gap in the current literature. Recognising sildenafil's broader 
      potential may unveil new treatment avenues, optimising existing approaches and 
      broadening its clinical application.
FAU - Puscasu, Ciprian
AU  - Puscasu C
AUID- ORCID: 0009-0003-7259-7942
AD  - Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian 
      Vuia 6, 020956 Bucharest, Romania.
FAU - Zanfirescu, Anca
AU  - Zanfirescu A
AUID- ORCID: 0000-0001-7658-5082
AD  - Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian 
      Vuia 6, 020956 Bucharest, Romania.
FAU - Negres, Simona
AU  - Negres S
AD  - Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian 
      Vuia 6, 020956 Bucharest, Romania.
FAU - Seremet, Oana Cristina
AU  - Seremet OC
AUID- ORCID: 0000-0002-0816-0012
AD  - Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian 
      Vuia 6, 020956 Bucharest, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231217
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - BW9B0ZE037 (Sildenafil Citrate)
RN  - 0 (Piperazines)
RN  - 0 (Purines)
RN  - 0 (Phosphodiesterase 5 Inhibitors)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Male
MH  - Humans
MH  - Sildenafil Citrate/pharmacology/therapeutic use
MH  - *Piperazines/pharmacology
MH  - *Purines/pharmacology
MH  - Phosphodiesterase 5 Inhibitors/pharmacology/therapeutic use
MH  - Cyclic GMP/metabolism
PMC - PMC10744870
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cancer
OT  - depression
OT  - drug repurposing
OT  - sildenafil
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:44
MHDA- 2023/12/25 06:42
PMCR- 2023/12/17
CRDT- 2023/12/23 01:15
PHST- 2023/11/30 00:00 [received]
PHST- 2023/12/11 00:00 [revised]
PHST- 2023/12/14 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/23 12:44 [pubmed]
PHST- 2023/12/23 01:15 [entrez]
PHST- 2023/12/17 00:00 [pmc-release]
AID - medicina59122190 [pii]
AID - medicina-59-02190 [pii]
AID - 10.3390/medicina59122190 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.