PMID- 38138894 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231225 IS - 2075-4426 (Print) IS - 2075-4426 (Electronic) IS - 2075-4426 (Linking) VI - 13 IP - 12 DP - 2023 Nov 28 TI - Survival Outcomes and Health-Related Quality of Life in Older Adults Diagnosed with Acute Myeloid Leukemia Receiving Frontline Therapy in Daily Practice. LID - 10.3390/jpm13121667 [doi] LID - 1667 AB - Acute myeloid leukemia has a poor prognosis in older adults, and its management is often unclear due to its underrepresentation in clinical trials. Both overall survival (OS) and health-related quality-of-life (HRQoL) are key outcomes in this population, and patient-reported outcomes may contribute to patient stratification and treatment assignment. This prospective study included 138 consecutive patients treated in daily practice with the currently available non-targeted therapies (intensive chemotherapy [IC], attenuated chemotherapy [AC], hypomethylating agents [HMA], or palliative care [PC]). We evaluated patients' condition at diagnosis (Life expectancy [Lee Index for Older Adults], Geriatric Assessment in Hematology [GAH scale], HRQoL [EQ-5D-5L questionnaire], and fatigue [fatigue items of the QLQ-C30 scale]), OS, early death (ED), treatment tolerability (TT) and change in HRQoL over 12 months follow-up. The median OS was 7.1 months (IC not reached, AC 5.9, HMA 8.8, and PC 1.0). Poor risk AML category and receiving just palliative care, as well as a higher Lee index score in the patients receiving active therapy, independently predicted a shorter OS. The Lee Index and GAH scale were not useful for predicting TT. The white blood cell count was a valid predictor for ED. Patients' HRQoL remained stable during follow-up. FAU - Ramos, Fernando AU - Ramos F AUID- ORCID: 0000-0002-4991-2655 AD - Department of Hematology, Hospital Universitario de Leon, 24008 Leon, Spain. FAU - Hermosin, Maria Lourdes AU - Hermosin ML AD - Department of Hematology, Hospital Universitario de Jerez de la Frontera, 11407 Jerez de la Frontera, Spain. FAU - Fuertes-Nunez, Marta AU - Fuertes-Nunez M AD - Department of Hematology, Hospital Universitario de Leon, 24008 Leon, Spain. FAU - Martinez, Pilar AU - Martinez P AD - Department of Hematology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain. FAU - Rodriguez-Medina, Carlos AU - Rodriguez-Medina C AD - Department of Hematology, Hospital Universitario de Gran Canaria Dr. Negrin, 35010 Las Palmas de Gran Canaria, Spain. FAU - Barrios, Manuel AU - Barrios M AD - Department of Hematology, Hospital Regional Universitario de Malaga, 29010 Malaga, Spain. FAU - Ibanez, Francisco AU - Ibanez F AD - Department of Hematology, Hospital General Universitario de Valencia, 46014 Valencia, Spain. FAU - Bernal, Teresa AU - Bernal T AUID- ORCID: 0000-0002-2338-513X AD - Department of Hematology, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain. FAU - Olave, Maria Teresa AU - Olave MT AD - Department of Hematology, Hospital Clinico Lozano Blesa, 50009 Zaragoza, Spain. FAU - Alvarez, Miguel Angel AU - Alvarez MA AUID- ORCID: 0009-0008-0740-8929 AD - Department of Hematology, Hospital Universitario de Getafe, 28905 Getafe, Spain. FAU - Vahi, Maria AU - Vahi M AD - Department of Hematology, Hospital Universitario Virgen de Valme, 41014 Sevilla, Spain. FAU - Caballero-Velazquez, Teresa AU - Caballero-Velazquez T AUID- ORCID: 0000-0001-7487-3793 AD - Department of Hematology, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain. FAU - Gonzalez, Bernardo AU - Gonzalez B AD - Department of Hematology, Hospital Universitario de Canarias, 38320 La Laguna, Spain. FAU - Altes, Albert AU - Altes A AD - Department of Hematology, Hospital Sant Joan de Deu de Manresa-Fundacio Althaia, 08243 Manresa, Spain. FAU - Garcia, Lorena AU - Garcia L AD - Department of Hematology, Complejo Hospitalario Universitario A Coruna (CHUAC), 15006 A Coruna, Spain. FAU - Fernandez, Pascual AU - Fernandez P AUID- ORCID: 0000-0002-4831-8849 AD - Department of Hematology, Hospital General Universitario de Alicante, 03010 Alicante, Spain. FAU - Duran, Maria Antonia AU - Duran MA AD - Department of Hematology, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain. FAU - Lopez, Rocio AU - Lopez R AD - Medical Department, Hematology Area, Bristol Myers Squibb Company, Celgene, 28050 Madrid, Spain. FAU - Rafel, Montserrat AU - Rafel M AD - Medical Department, Hematology Area, Bristol Myers Squibb Company, Celgene, 28050 Madrid, Spain. FAU - Serrano, Josefina AU - Serrano J AD - Department of Hematology, Hospital Universitario Reina Sofia, IMIBIC UCO, 14004 Cordoba, Spain. LA - eng GR - none/Celgene Spain (a Bristol Myers Squibb company)/ PT - Journal Article DEP - 20231128 PL - Switzerland TA - J Pers Med JT - Journal of personalized medicine JID - 101602269 PMC - PMC10744855 OTO - NOTNLM OT - acute myeloid leukemia OT - early death OT - elderly OT - fatigue OT - geriatric assessment OT - health-related quality of life OT - life expectancy OT - survival COIS- CRM has received research grants from Astellas, speaker honorarium from BMS, Astellas, and Abbvie, and travel grants from Servier and BMS. MR is an employee and RL was an employee of Bristol Myers Squibb Company, Celgene. The rest of the authors declare no conflict of interest. EDAT- 2023/12/23 12:44 MHDA- 2023/12/23 12:45 PMCR- 2023/11/28 CRDT- 2023/12/23 01:18 PHST- 2023/08/02 00:00 [received] PHST- 2023/10/25 00:00 [revised] PHST- 2023/11/14 00:00 [accepted] PHST- 2023/12/23 12:45 [medline] PHST- 2023/12/23 12:44 [pubmed] PHST- 2023/12/23 01:18 [entrez] PHST- 2023/11/28 00:00 [pmc-release] AID - jpm13121667 [pii] AID - jpm-13-01667 [pii] AID - 10.3390/jpm13121667 [doi] PST - epublish SO - J Pers Med. 2023 Nov 28;13(12):1667. doi: 10.3390/jpm13121667.