PMID- 38138976
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240103
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 24
DP  - 2023 Dec 5
TI  - Astrocyte Involvement in Blood-Brain Barrier Function: A Critical Update 
      Highlighting Novel, Complex, Neurovascular Interactions.
LID - 10.3390/ijms242417146 [doi]
LID - 17146
AB  - Neurological disorders have been linked to a defective blood-brain barrier (BBB), 
      with dysfunctions triggered by stage-specific disease mechanisms, some of these 
      being generated through interactions in the neurovascular unit (NVU). Advanced 
      knowledge of molecular and signaling mechanisms in the NVU and the emergence of 
      improved experimental models allow BBB permeability prediction and the 
      development of new brain-targeted therapies. As NVU constituents, astrocytes are 
      the most numerous glial cells, characterized by a heterogeneity that occurs as a 
      result of developmental and context-based gene expression profiles and the 
      differential expression of non-coding ribonucleic acids (RNAs). Due to their 
      heterogeneity and dynamic responses to different signals, astrocytes may have a 
      beneficial or detrimental role in the BBB's barrier function, with deep effects 
      on the pathophysiology of (and on the progression of) central nervous system 
      diseases. The implication of astrocytic-derived extracellular vesicles in 
      pathological mechanisms, due to their ability to pass the BBB, must also be 
      considered. The molecular mechanisms of astrocytes' interaction with endothelial 
      cells at the BBB level are considered promising therapeutic targets in different 
      neurological conditions. Nevertheless, a personalized and well-founded approach 
      must be addressed, due to the temporal and spatial heterogeneity of reactive 
      astrogliosis states during disease.
FAU - Manu, Doina Ramona
AU  - Manu DR
AUID- ORCID: 0000-0001-8374-4977
AD  - Centre for Advanced Medical and Pharmaceutical Research, "George Emil Palade" 
      University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, 
      Romania.
FAU - Slevin, Mark
AU  - Slevin M
AD  - Centre for Advanced Medical and Pharmaceutical Research, "George Emil Palade" 
      University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, 
      Romania.
AD  - Department of Life Sciences, Manchester Metropolitan University, Manchester M15 
      6BH, UK.
FAU - Barcutean, Laura
AU  - Barcutean L
AUID- ORCID: 0000-0002-3033-0583
AD  - Neurology 1 Clinic, County Emergency Clinical Hospital, 540136 Targu Mures, 
      Romania.
AD  - Department of Neurology, "George Emil Palade" University of Medicine, Pharmacy, 
      Science and Technology, 540142 Targu Mures, Romania.
FAU - Forro, Timea
AU  - Forro T
AUID- ORCID: 0000-0002-5137-1819
AD  - Doctoral School, "George Emil Palade" University of Medicine, Pharmacy, Science 
      and Technology, 540142 Targu Mures, Romania.
FAU - Boghitoiu, Tudor
AU  - Boghitoiu T
AD  - Psychiatry II Clinic, County Clinical Hospital, 540072 Targu Mures, Romania.
FAU - Balasa, Rodica
AU  - Balasa R
AD  - Neurology 1 Clinic, County Emergency Clinical Hospital, 540136 Targu Mures, 
      Romania.
AD  - Department of Neurology, "George Emil Palade" University of Medicine, Pharmacy, 
      Science and Technology, 540142 Targu Mures, Romania.
LA  - eng
GR  - 10126/2/17.12.2020./University of Medicine and Pharmacy of Targu Mures/
PT  - Journal Article
PT  - Review
DEP - 20231205
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Humans
MH  - *Astrocytes/metabolism
MH  - Blood-Brain Barrier/metabolism
MH  - Endothelial Cells/physiology
MH  - Brain/metabolism
MH  - Biological Transport
MH  - *Nervous System Diseases/metabolism
PMC - PMC10743219
OTO - NOTNLM
OT  - astrocyte
OT  - blood-brain barrier
OT  - central nervous system
OT  - endothelial cell
OT  - neurovascular unit
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:43
MHDA- 2023/12/25 06:42
PMCR- 2023/12/05
CRDT- 2023/12/23 01:19
PHST- 2023/11/03 00:00 [received]
PHST- 2023/11/28 00:00 [revised]
PHST- 2023/12/02 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/23 12:43 [pubmed]
PHST- 2023/12/23 01:19 [entrez]
PHST- 2023/12/05 00:00 [pmc-release]
AID - ijms242417146 [pii]
AID - ijms-24-17146 [pii]
AID - 10.3390/ijms242417146 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Dec 5;24(24):17146. doi: 10.3390/ijms242417146.