PMID- 38139436
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 24
DP  - 2023 Dec 18
TI  - The Potential Role of Gossypetin in the Treatment of Diabetes Mellitus and Its 
      Associated Complications: A Review.
LID - 10.3390/ijms242417609 [doi]
LID - 17609
AB  - Type 2 diabetes mellitus (T2DM) is a metabolic disorder caused by insulin 
      resistance and dysfunctional beta (beta)-cells in the pancreas. Hyperglycaemia is a 
      characteristic of uncontrolled diabetes which eventually leads to fatal organ 
      system damage. In T2DM, free radicals are continuously produced, causing 
      extensive tissue damage and subsequent macro-and microvascular complications. The 
      standard approach to managing T2DM is pharmacological treatment with 
      anti-diabetic medications. However, patients' adherence to treatment is 
      frequently decreased by the side effects and expense of medications, which has a 
      detrimental impact on their health outcomes. Quercetin, a flavonoid, is a one of 
      the most potent anti-oxidants which ameliorates T2DM. Thus, there is an increased 
      demand to investigate quercetin and its derivatives, as it is hypothesised that 
      similar structured compounds may exhibit similar biological activity. Gossypetin 
      is a hexahydroxylated flavonoid found in the calyx of Hibiscus sabdariffa. 
      Gossypetin has a similar chemical structure to quercetin with an extra hydroxyl 
      group. Furthermore, previous literature has elucidated that gossypetin exhibits 
      neuroprotective, hepatoprotective, reproprotective and nephroprotective 
      properties. The mechanisms underlying gossypetin's therapeutic potential have 
      been linked to its anti-oxidant, anti-inflammatory and immunomodulatory 
      properties. Hence, this review highlights the potential role of gossypetin in the 
      treatment of diabetes and its associated complications.
FAU - Naidoo, Karishma
AU  - Naidoo K
AUID- ORCID: 0000-0002-3601-6333
AD  - Department of Human Physiology, School of Laboratory Medicine and Medical 
      Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
FAU - Khathi, Andile
AU  - Khathi A
AUID- ORCID: 0000-0002-2246-0038
AD  - Department of Human Physiology, School of Laboratory Medicine and Medical 
      Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
LA  - eng
GR  - UID130598/National Research Foundation/
PT  - Journal Article
PT  - Review
DEP - 20231218
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - SET4M23ZTM (gossypetin)
RN  - 9IKM0I5T1E (Quercetin)
RN  - 0 (Flavonoids)
RN  - 0 (Antioxidants)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Quercetin/therapeutic use
MH  - Flavonoids/therapeutic use/pharmacology
MH  - Antioxidants/therapeutic use
PMC - PMC10743819
OTO - NOTNLM
OT  - diabetes mellitus
OT  - flavonoid
OT  - gossypetin
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:43
MHDA- 2023/12/25 06:43
PMCR- 2023/12/18
CRDT- 2023/12/23 01:22
PHST- 2023/11/23 00:00 [received]
PHST- 2023/12/14 00:00 [revised]
PHST- 2023/12/15 00:00 [accepted]
PHST- 2023/12/25 06:43 [medline]
PHST- 2023/12/23 12:43 [pubmed]
PHST- 2023/12/23 01:22 [entrez]
PHST- 2023/12/18 00:00 [pmc-release]
AID - ijms242417609 [pii]
AID - ijms-24-17609 [pii]
AID - 10.3390/ijms242417609 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Dec 18;24(24):17609. doi: 10.3390/ijms242417609.