PMID- 38140295
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 24
DP  - 2023 Dec 8
TI  - Clinical Significance of Nutritional Status, Inflammation, and Body Composition 
      in Elderly Hemodialysis Patients-A Case-Control Study.
LID - 10.3390/nu15245036 [doi]
LID - 5036
AB  - Nutritional and inflammatory disorders are factors that increase the risk of 
      adverse clinical outcomes and mortality in elderly hemodialysis (HD) patients. 
      This study aimed to examine nutritional and inflammation status as well as body 
      composition in older adults on HD compared to matched controls. A case-control 
      study was conducted on 168 older participants (84 HD patients (cases) and 84 
      controls) age- and sex-matched. Demographic, clinical, anthropometric, and 
      laboratory parameters were collected from medical records. The primary outcome 
      was nutritional status assessment using a combination of nutritional and 
      inflammatory markers along with the geriatric nutritional risk index (GNRI). 
      Sarcopenic obesity (SO) was studied by the combined application of anthropometric 
      measures. Body composition and hydration status were assessed by bioelectrical 
      impedance analysis (BIA). Univariate and multivariate regression analyses were 
      performed to identify nutritional and inflammatory independent risk indicators in 
      elderly HD patients and controls. A significantly high prevalence of nutritional 
      risk measured by the GNRI was found in HD patients (32.1%) compared to controls 
      (6.0%) (p < 0.001). Elderly HD patients were overweight and had lower percent arm 
      muscle circumference, phase angle (PA), serum albumin (s-albumin), as well as 
      higher percent extracellular body water (ECW%) and serum C-reactive protein 
      (s-CRP) than controls (all at least, p < 0.01). SO was higher in HD patients 
      (15.50%) than in controls (14.30%). By multi-regression analyses, age < 75 years 
      (OR: 0.119; 95%CI: 0.036 to 0.388), ECW% (OR: 1.162; 95%CI: 1.061 to 1.273), PA 
      (OR: 0.099; 95%CI: 0.036 to 0.271), as well as BMI, s-albumin >/= 3.8 g/dL, and 
      lower s-CRP were independently related between cases and controls (all at least, 
      p < 0.05). Elderly HD patients had increased nutritional risk, SO, inflammation, 
      overhydration, and metabolic derangements compared to controls. This study 
      highlights the importance of identifying nutritional risk along with inflammation 
      profile and associated body composition disorders in the nutritional care of 
      elderly HD patients. Further studies are needed to prevent nutritional disorders 
      in elderly HD patients.
FAU - Ruperto, Mar
AU  - Ruperto M
AUID- ORCID: 0000-0002-8790-4007
AD  - Department of Pharmaceutical & Health Sciences, School of Pharmacy, Universidad 
      San Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, 28660 Alcorcon, 
      Madrid, Spain.
FAU - Barril, Guillermina
AU  - Barril G
AUID- ORCID: 0000-0003-4067-634X
AD  - Nephrology Department, Hospital Universitario La Princesa, C/Diego de Leon 62, 
      28006 Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20231208
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Nutritional Status
MH  - Case-Control Studies
MH  - Clinical Relevance
MH  - *Kidney Failure, Chronic/complications
MH  - Body Mass Index
MH  - Renal Dialysis/adverse effects
MH  - Body Composition
MH  - Obesity/etiology
MH  - Inflammation/etiology
MH  - C-Reactive Protein/analysis
MH  - Serum Albumin/analysis
MH  - Electric Impedance
PMC - PMC10745431
OTO - NOTNLM
OT  - aging
OT  - bioimpedance analysis
OT  - body composition
OT  - case-control study
OT  - elderly
OT  - geriatric nutritional risk
OT  - hemodialysis
OT  - inflammation
OT  - obesity
OT  - older adults
OT  - phase angle
OT  - s-albumin
OT  - sarcopenic obesity
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/23 12:44
MHDA- 2023/12/25 06:42
PMCR- 2023/12/08
CRDT- 2023/12/23 01:27
PHST- 2023/10/28 00:00 [received]
PHST- 2023/12/02 00:00 [revised]
PHST- 2023/12/06 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/23 12:44 [pubmed]
PHST- 2023/12/23 01:27 [entrez]
PHST- 2023/12/08 00:00 [pmc-release]
AID - nu15245036 [pii]
AID - nutrients-15-05036 [pii]
AID - 10.3390/nu15245036 [doi]
PST - epublish
SO  - Nutrients. 2023 Dec 8;15(24):5036. doi: 10.3390/nu15245036.