PMID- 38140798 OWN - NLM STAT- MEDLINE DCOM- 20240308 LR - 20240320 IS - 1988-9518 (Electronic) IS - 0214-3429 (Print) IS - 0214-3429 (Linking) VI - 37 IP - 2 DP - 2024 Apr TI - Safety of fluoroquinolones. PG - 127-133 LID - barberan22dec2023 [pii] LID - 10.37201/req/143.2023 [doi] AB - Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen degradation, such as tendonitis, Achilles tendon rupture, aortic aneurysm, and retinal detachment. This article reviews the main potentially threatening AEs, the alarms issued by regulatory agencies and therapeutic alternatives. CI - (c)The Author 2023. Published by Sociedad Espanola de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/). FAU - Barberan, J AU - Barberan J AD - Jose Barberan, Hospital Universitario HM Monteprincipe, Facultad HM Hospitales de Ciencias de la Salud, Universidad Camilo Jose Cela, Madrid, Spain. jose.barberan@ucjc.edu. FAU - de la Cuerda, A AU - de la Cuerda A FAU - Tejeda Gonzalez, M I AU - Tejeda Gonzalez MI FAU - Lopez Aparicio, A AU - Lopez Aparicio A FAU - Monfort Vinuesa, C AU - Monfort Vinuesa C FAU - Ramos Sanchez, A AU - Ramos Sanchez A FAU - Barberan, L C AU - Barberan LC LA - eng PT - Journal Article PT - Review DEP - 20231222 PL - Spain TA - Rev Esp Quimioter JT - Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia JID - 9108821 RN - 0 (Fluoroquinolones) RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - *Fluoroquinolones/adverse effects MH - Anti-Bacterial Agents/adverse effects MH - *Tendinopathy/chemically induced PMC - PMC10945095 OTO - NOTNLM OT - Fluoroquinolones OT - adverse effects OT - aortic aneurism OT - dysglycemia OT - neuropathy OT - tendon rupture COIS- JB have received honoraria for lectures and advisory boards for Pfizer, Wyeth, Merck, Angelini, Menarini, Meiji Pharma Spain, Shionogi and Gilead. Rest of authors declare no conflict of interest. EDAT- 2023/12/23 12:44 MHDA- 2024/03/08 06:43 PMCR- 2024/01/01 CRDT- 2023/12/23 03:04 PHST- 2024/03/08 06:43 [medline] PHST- 2023/12/23 12:44 [pubmed] PHST- 2023/12/23 03:04 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - barberan22dec2023 [pii] AID - revespquimioter-37-127 [pii] AID - 10.37201/req/143.2023 [doi] PST - ppublish SO - Rev Esp Quimioter. 2024 Apr;37(2):127-133. doi: 10.37201/req/143.2023. Epub 2023 Dec 22.