PMID- 38140870
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240130
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 39
IP  - 12
DP  - 2023 Dec
TI  - [Upregulation of IL-18 expression in blood CD4(+) Th2 cells of patients with 
      allergic rhinitis].
PG  - 1100-1107
AB  - Objective To investigate the expressions of IL-18, IL-18 binding protein isoform 
      a (IL-18BPa) and IL-18 receptor alpha (IL-18Ralpha) in blood CD4(+) Th2 cells of patients 
      with allergic rhinitis (AR) and the effects of allergens on their expressions. 
      Methods Blood samples of AR patients and healthy control subjects (HCs) were 
      collected. Peripheral blood mononuclear cells (PBMCs) and CD4(+) T cells sorted 
      by immunomagnetic beads were stimulated by crude extract of Artemisia sieversiana 
      wild allergen (ASWE), Platanus pollen (PPE) and house dust mite extract (HDME). 
      Flow cytometry was used to detect the expression of IL-18, IL-18BPa and IL-18Ralpha 
      in CD4(+) Th2 cells, and BioPlex was used to detect the level of plasma IL-4 and 
      analyze its correlation with the proportion of IL-18(+) Th2 cells. Results 
      Compared with HCs, the proportion of IL-18(+) cells was increased in Th2 cells of 
      AR patients; MFI of IL-18 was increased, while that of IL-18Ralpha was decreased. 
      Moreover, allergens induced IL-18 and IL-18Ralpha expression in sorted CD4(+) Th2 
      cells of HCs and induced IL-18Ralpha in that of AR patients. Additionally, elevated 
      plasma IL-4 level was found in AR patients, which was moderately correlated with 
      the percentage of IL-18(+) Th2 cells. Conclusion Allergens may be involved in the 
      pathogenesis of AR by inducing expression of IL-18 in peripheral blood CD4(+) Th2 
      cells.
FAU - Wang, Junling
AU  - Wang J
AD  - Department of Critical Care Medicine, Henan Provincial People's Hospital, 
      Zhengzhou 450003; Department of Respiration, Huaihe Hospital of Henan University, 
      Kaifeng 475000; Allergy and Clinical Immunology Research Centre, First Affiliated 
      Hospital of Jinzhou Medical University, Jinzhou 121000, China.
FAU - Shao, Huanzhang
AU  - Shao H
AD  - Department of Critical Care Medicine, Henan Provincial People's Hospital, 
      Zhengzhou 450003, China.
FAU - Ye, Ling
AU  - Ye L
AD  - Department of Critical Care Medicine, Henan Provincial People's Hospital, 
      Zhengzhou 450003, China.
FAU - Zhang, Yijie
AU  - Zhang Y
AD  - Department of Respiration, Huaihe Hospital of Henan University, Kaifeng 475000, 
      China. *Corresponding authors, E-mail: 13903782431@163.com.
FAU - Qin, Bingyu
AU  - Qin B
AD  - Department of Critical Care Medicine, Henan Provincial People's Hospital, 
      Zhengzhou 450003; Department of Respiration, Huaihe Hospital of Henan University, 
      Kaifeng 475000, China. *Corresponding authors, E-mail: nicolasby@126.com.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Interleukin-18)
RN  - 207137-56-2 (Interleukin-4)
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - *Th2 Cells
MH  - Interleukin-18/metabolism
MH  - Up-Regulation
MH  - Leukocytes, Mononuclear/metabolism
MH  - Interleukin-4/metabolism
MH  - *Rhinitis, Allergic/metabolism
MH  - Allergens
MH  - Cytokines/metabolism
EDAT- 2023/12/23 12:44
MHDA- 2023/12/25 06:43
CRDT- 2023/12/23 05:27
PHST- 2023/12/25 06:43 [medline]
PHST- 2023/12/23 12:44 [pubmed]
PHST- 2023/12/23 05:27 [entrez]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2023 Dec;39(12):1100-1107.