PMID- 38141682
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240206
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 350
DP  - 2024 Feb
TI  - A cytotoxicity and mechanistic investigation of mono- and di-chloro naphthalenes.
PG  - 141004
LID - S0045-6535(23)03274-5 [pii]
LID - 10.1016/j.chemosphere.2023.141004 [doi]
AB  - Polychlorinated naphthalenes (PCNs) were characterized as persistent organic 
      pollutants (POPs) that were widely distributed in the environment. Although the 
      striking in vivo toxicity of these pollutants towards both animals and humans was 
      well documented, their cytotoxicity and mechanism of action have not been 
      extensively investigated. In this study, the in vitro antiproliferative activity 
      of mono- and di-chloronaphthalenes as representative PCNs were evaluated and the 
      results indicated strong growth inhibitory effects against mammalian cells, 
      especially the human breast MCF-10A cell and human hepatic HL-7702 cells. 
      2-Chloronaphthalene with the most potent antiproliferative effects within the 
      tested PCNs, which showed IC(50) values ranging from 0.3 mM to 1.5 mM against 
      selected human cell lines, was investigated for its working mechanisms. It 
      promoted cellular apoptosis of MCF-10A cells upon the concentration of 200 muM. It 
      also induced the autophagy of MCF-10A cells in a dose-dependent manner, resulting 
      in cell death via the interaction of autophagy and apoptosis. Thus, these 
      findings supported the theoretical foundation for interventional treatment of 
      PCNs toxicity and also provided implications for the use of chemopreventive 
      agents against the toxic chlorinated naphthalenes in the environments.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Cai, Chenglin
AU  - Cai C
AD  - China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, China.
FAU - Qian, Jiajun
AU  - Qian J
AD  - School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Xiang, Shouyan
AU  - Xiang S
AD  - School of Environmental Science and Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Wang, Chenhao
AU  - Wang C
AD  - School of Environmental Science and Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Ji, Yufeng
AU  - Ji Y
AD  - Faculty of Engineering and Information Technology, The University of Melbourne, 
      Melbourne, Australia.
FAU - Cui, Jiahua
AU  - Cui J
AD  - School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China. Electronic address: cpucjh@sjtu.edu.cn.
FAU - Jia, Jinping
AU  - Jia J
AD  - China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, China; 
      School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China. Electronic address: jpjia@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231221
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Naphthalenes)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Environmental Pollutants/analysis
MH  - Liver/chemistry
MH  - Naphthalenes/toxicity/analysis
MH  - Apoptosis
MH  - Mammals
OTO - NOTNLM
OT  - Apoptosis
OT  - Autophagy
OT  - Chloronaphthalenes
OT  - Cytotoxicity
OT  - Volatile organic compounds
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/24 09:42
MHDA- 2024/01/29 06:44
CRDT- 2023/12/23 19:24
PHST- 2022/11/04 00:00 [received]
PHST- 2023/12/01 00:00 [revised]
PHST- 2023/12/19 00:00 [accepted]
PHST- 2024/01/29 06:44 [medline]
PHST- 2023/12/24 09:42 [pubmed]
PHST- 2023/12/23 19:24 [entrez]
AID - S0045-6535(23)03274-5 [pii]
AID - 10.1016/j.chemosphere.2023.141004 [doi]
PST - ppublish
SO  - Chemosphere. 2024 Feb;350:141004. doi: 10.1016/j.chemosphere.2023.141004. Epub 
      2023 Dec 21.