PMID- 38141686
OWN - NLM
STAT- Publisher
LR  - 20240422
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
DP  - 2023 Dec 21
TI  - Comparing a 19-gauge fine-needle biopsy needle with a 22-gauge fine-needle biopsy 
      needle for EUS-guided liver biopsy sampling: a prospective randomized study.
LID - S0016-5107(23)03166-8 [pii]
LID - 10.1016/j.gie.2023.12.022 [doi]
AB  - BACKGROUND AND AIMS: EUS-guided liver biopsy (EUS-LB) sampling is being 
      increasingly used. We performed a prospective randomized trial to compare 
      specimen adequacy of a 19-gauge fine-needle biopsy (FNB) needle with a 22-gauge 
      FNB Franseen tip needle for EUS-LB sampling. METHODS: Forty-two consecutive 
      patients referred for EUS-LB sampling were prospectively randomized to a 19-gauge 
      or 22-gauge FNB needle. When the specimen with the 22-gauge needle was 
      macroscopically inadequate, an additional pass with the 19-gauge needle was done. 
      Bilobar EUS-LB sampling was performed with heparinized wet suction using 1 pass 
      and 3 actuations per lobe. Descriptive statistics were computed for all 
      variables. RESULTS: Biopsy sampling was performed for abnormal liver enzymes in 
      95.5% of patients (57% women; average age, 51 years). Five patients undergoing 
      sampling with the 22-gauge FNB needle had macroscopically inadequate specimens 
      and required additional biopsy sampling with the 19-gauge FNB needle. Mean 
      preprocessing length of the longest tissue core was 21.5 +/- 6.3 mm with a 19-gauge 
      FNB needle compared with 9.4 +/- 5.5 mm with the 22-gauge FNB needle (P < .001). 
      Postprocessing specimens were significantly longer with 19-gauge than with 
      22-gauge FNB needles (17.4 mm vs 6.8, P < .001). There were no adverse events, 
      and postprocedure pain and discomfort was similar in both groups (14% for 
      19-gauge vs 10% for 22-gauge, P = .99). CONCLUSIONS: Liver core biopsy sampling 
      using the 19-gauge FNB needle is superior to the 22-gauge FNB needle in terms of 
      length of longest core and aggregate specimen length. Considerably more 
      fragmentation of the 22-gauge cores occurs during tissue processing. No increased 
      postprocedure pain or AEs were found with the 19-gauge needle. A 19-gauge FNB 
      needle is preferred to the 22-gauge FNB needle for EUS-LB. (Clinical trial 
      registration number: NCT04806607.).
CI  - Copyright (c) 2023 American Society for Gastrointestinal Endoscopy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Diehl, David L
AU  - Diehl DL
AD  - Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical 
      Center, Danville, Pennsylvania, USA.
FAU - Sangwan, Vikas
AU  - Sangwan V
AD  - Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical 
      Center, Danville, Pennsylvania, USA.
FAU - Johal, Amitpal S
AU  - Johal AS
AD  - Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical 
      Center, Danville, Pennsylvania, USA.
FAU - Khara, Harshit S
AU  - Khara HS
AD  - Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical 
      Center, Danville, Pennsylvania, USA.
FAU - Confer, Bradley
AU  - Confer B
AD  - Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical 
      Center, Danville, Pennsylvania, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT04806607
PT  - Journal Article
DEP - 20231221
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
SB  - IM
COIS- Disclosure The following authors disclosed financial relationships: D. L. Diehl: 
      Consultant for Boston Scientific, Olympus, and Cook Medical. H. S. Khara: 
      Consultant for Boston Scientific, Olympus, and Medtronic. B. Confer: Speaker for 
      Boston Scientific; consultant for Exact Sciences. All other authors disclosed no 
      financial relationships.
EDAT- 2023/12/24 09:41
MHDA- 2023/12/24 09:41
CRDT- 2023/12/23 19:24
PHST- 2023/08/05 00:00 [received]
PHST- 2023/10/27 00:00 [revised]
PHST- 2023/12/17 00:00 [accepted]
PHST- 2023/12/24 09:41 [pubmed]
PHST- 2023/12/24 09:41 [medline]
PHST- 2023/12/23 19:24 [entrez]
AID - S0016-5107(23)03166-8 [pii]
AID - 10.1016/j.gie.2023.12.022 [doi]
PST - aheadofprint
SO  - Gastrointest Endosc. 2023 Dec 21:S0016-5107(23)03166-8. doi: 
      10.1016/j.gie.2023.12.022.