PMID- 38141872
OWN - NLM
STAT- MEDLINE
DCOM- 20240401
LR  - 20240401
IS  - 2174-2030 (Electronic)
IS  - 0870-2551 (Linking)
VI  - 43
IP  - 4
DP  - 2024 Apr
TI  - Clinical outcomes of percutaneous coronary intervention in chronic total 
      occlusion in patients with type 2 diabetes mellitus.
PG  - 167-174
LID - S0870-2551(23)00499-7 [pii]
LID - 10.1016/j.repc.2023.07.009 [doi]
AB  - INTRODUCTION AND OBJECTIVES: Coronary chronic total occlusions (CTOs) are 
      relatively common findings in patients with type 2 diabetes mellitus (T2DM). 
      However, the indication for percutaneous coronary intervention (PCI) and its 
      clinical benefit in these patients remain controversial. METHODS: A single-center 
      retrospective cohort study with prospectively collected outcomes was carried out 
      with CTO patients undergoing PCI in 2019 and 2020. Patients were divided into two 
      groups according to previous T2DM diagnosis (T2DM and non-T2DM). The primary 
      outcome was recurrence of angina and/or heart failure symptoms and secondary 
      outcomes were myocardial infarction and all-cause mortality. RESULTS: A total of 
      177 patients (82.5% male) were included in the analysis, with a mean age of 65+/-11 
      years. The primary outcome (total symptom recurrence) occurred in 16.6% of the 
      sample, with no difference between groups (non-T2DM 13.6% vs. T2DM 21.2%, 
      p=0.194) in a two-year follow-up. Angina recurrence was significantly more 
      frequent in T2DM patients (15.2%, p=0.043). The presence of T2DM was not an 
      independent predictor of symptom recurrence (p=0.429, HR 1.37, 95% CI 0.62-2.98). 
      Myocardial infarction and all-cause mortality were also not different between 
      groups (T2DM 1.5%, p=0.786 and 4.5%, p=0.352, respectively, on survival 
      analysis). Independent predictors of all-cause mortality were left ventricular 
      function and creatine clearance (p=0.039, HR 0.92, 95% CI 0.85-0.99 and p=0.013, 
      HR 0.96, 95% CI 0.93-0.99, respectively). CONCLUSIONS: T2DM did not influence 
      outcomes in CTO patients undergoing PCI, and its presence should not be a 
      limiting factor in deciding on CTO revascularization.
CI  - Copyright (c) 2023 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Costa, Hugo
AU  - Costa H
AD  - Cardiology Department, Centro Hospitalar Universitario do Algarve, Portugal. 
      Electronic address: hugoalexcosta@sapo.pt.
FAU - Espirito-Santo, Miguel
AU  - Espirito-Santo M
AD  - Cardiology Department, Centro Hospitalar Universitario do Algarve, Portugal.
FAU - Bispo, Joao
AU  - Bispo J
AD  - Cardiology Department, Centro Hospitalar Universitario do Algarve, Portugal.
FAU - Guedes, Joao
AU  - Guedes J
AD  - Cardiology Department, Centro Hospitalar Universitario do Algarve, Portugal.
FAU - Mimoso, Jorge
AU  - Mimoso J
AD  - Cardiology Department, Centro Hospitalar Universitario do Algarve, Portugal.
FAU - Palmeiro, Hugo
AU  - Palmeiro H
AD  - Cardiology Department, Centro Hospitalar Universitario do Algarve, Portugal.
FAU - Baptista Goncalves, Rui
AU  - Baptista Goncalves R
AD  - Public Health Online Programmes, University of Liverpool, United Kingdom.
FAU - Vinhas, Hugo
AU  - Vinhas H
AD  - Cardiology Department, Centro Hospitalar Universitario do Algarve, Portugal.
LA  - eng
LA  - por
PT  - Journal Article
DEP - 20231221
PL  - Portugal
TA  - Rev Port Cardiol
JT  - Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de 
      Cardiologia = Portuguese journal of cardiology : an official journal of the 
      Portuguese Society of Cardiology
JID - 8710716
RN  - Diabetes Mellitus, Noninsulin-Dependent, 2
SB  - IM
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Aged
MH  - Female
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - *Coronary Occlusion/surgery/complications/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Retrospective Studies
MH  - Chronic Disease
MH  - *Myocardial Infarction/etiology
MH  - Treatment Outcome
MH  - Risk Factors
OTO - NOTNLM
OT  - Chronic total occlusions
OT  - Clinical outcomes
OT  - Diabetes tipo 2
OT  - Oclusoes totais cronicas
OT  - Outcomes clinicos
OT  - Recorrencia de sintomas
OT  - Symptom recurrence
OT  - Type 2 diabetes
EDAT- 2023/12/24 09:42
MHDA- 2024/04/01 06:42
CRDT- 2023/12/23 19:27
PHST- 2023/03/21 00:00 [received]
PHST- 2023/06/07 00:00 [revised]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2024/04/01 06:42 [medline]
PHST- 2023/12/24 09:42 [pubmed]
PHST- 2023/12/23 19:27 [entrez]
AID - S0870-2551(23)00499-7 [pii]
AID - 10.1016/j.repc.2023.07.009 [doi]
PST - ppublish
SO  - Rev Port Cardiol. 2024 Apr;43(4):167-174. doi: 10.1016/j.repc.2023.07.009. Epub 
      2023 Dec 21.