PMID- 3814220
OWN - NLM
STAT- MEDLINE
DCOM- 19870311
LR  - 20151119
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 36
IP  - 11
DP  - 1986 Nov
TI  - Immunopharmacological actions of the new antiallergic drug 
      11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid. Effects on immunological 
      reactions in mice and in humans.
PG  - 1632-7
AB  - The effects of 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid (Sm 857), a 
      new antiallergic drug, on immunological reactions in mice and in humans were 
      investigated. The mouse hemolysin formation against sheep erythrocytes was not 
      suppressed by Sm 857 (10-100 mg/kg/d i.p., p.o.) for 3 days either before or 
      after immunization. The formation of anti-dinitrophenyl (DNP) IgE antibodies in 
      mice immunized with dinitrophenyl-conjugated ovalbumin (DNP-OA) and alum, was not 
      suppressed by Sm 857 (10-100 mg/kg i.p., p.o.) for 3 days either before or after 
      immunization, but the formation of anti-DNP IgG antibodies on 7 days after 
      immunization was slightly suppressed in the group of mice treated i.p. with 100 
      mg/kg/d of Sm 857 for 3 days after immunization. On the other hand, both the 
      proliferation of human peripheral blood lymphocytes (PBL) induced by concanavalin 
      A, phytohemagglutinin-P, pokeweed mitogen (PWM), protein A (Pro A) and Cowan I, 
      and the formation of IgM and IgG plaque forming cells by PBL stimulated with PWM 
      or Pro A, were suppressed significantly only in the presence of Sm 857 (10(-4) 
      g/ml). In addition, Sm 857 hardly affected the nitroblue tetrazolium reduction 
      test, phagocytosis and chemotaxis in human neutrophils.
FAU - Yanagihara, Y
AU  - Yanagihara Y
FAU - Shida, T
AU  - Shida T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Mitogens)
RN  - 0 (Quinazolines)
RN  - 298-83-9 (Nitroblue Tetrazolium)
RN  - N8F510M76F (doqualast)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antibody Formation/drug effects
MH  - Cell Movement/drug effects
MH  - Humans
MH  - Hypersensitivity/*drug therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mitogens/pharmacology
MH  - Neutrophils/drug effects
MH  - Nitroblue Tetrazolium
MH  - Phagocytosis/drug effects
MH  - Quinazolines/*pharmacology
MH  - Rosette Formation
MH  - Species Specificity
EDAT- 1986/11/01 00:00
MHDA- 1986/11/01 00:01
CRDT- 1986/11/01 00:00
PHST- 1986/11/01 00:00 [pubmed]
PHST- 1986/11/01 00:01 [medline]
PHST- 1986/11/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1986 Nov;36(11):1632-7.