PMID- 38142508
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240201
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1715
DP  - 2024 Jan 25
TI  - Surface multi-walled carbon nanotube modified quaternary amine-functionalized 
      polymers for purification and determination of glyphosate and its four 
      metabolites in plasma samples.
PG  - 464581
LID - S0021-9673(23)00806-3 [pii]
LID - 10.1016/j.chroma.2023.464581 [doi]
AB  - The present study focused on the pretreatment and detection of GLY and its four 
      metabolites AMPA, N-acetyl AMPA, N-methyl GLY and N-acetyl GLY in plasma samples. 
      Multi-walled carbon nanotube-modified quaternary amine-functionalized polymers 
      (QA-PDNV@MWCNTs) were synthesized in a controlled manner by self-assembly, and 
      its morphology and composition were extensively characterized. The QA-PDNV@MWCNTs 
      microspheres were then used as an SPE adsorbent for the preparation and rapid 
      determination of GLY and its four metabolites in plasma samples combined with 
      ultra-performance liquid chromatography-high resolution mass spectrometry 
      (UPLCHRMS). The SPE conditions based on QA-PDNV@MWCNTs were optimized for GLY and 
      its metabolites to obtain the best purification efficiency. The experimental 
      results show that when the adsorbent contains 8% MWCNTs, it can balance the 
      adsorption of target analytes and the purification performance of the adsorbent 
      for impurities. In addition, this study compared the QA-PDNV@MWCNTs based SPE 
      method with the commercial Waters Oasis MAX SPE cartridge and the results showed 
      that the developed method in this study has better resistance to matrix 
      interference. Under optimal conditions, the recoveries of GLY and its metabolites 
      spiked in plasma were 82.6-99.4 % with relative standard deviations (RSDs) of 
      1.0-7.8 %. The limits of detection (LODs, S/N >/= 3) and limits of quantification 
      (LOQs, S/N >/= 9) of the method were 0.05-0.33 mug/L and 0.15-1.00 mug/L, 
      respectively. Finally, the developed QA-PDNV@MWCNTs based SPE-UPLCHRMS method was 
      used to confirm GLY poisoning not only on the basis of the detection of the GLY 
      prototype, but also on the basis of its four metabolites.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Pan, Shengdong
AU  - Pan S
AD  - Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang 
      Province, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, 
      Zhejiang 315010, China. Electronic address: panshengdong0714@163.com.
FAU - Ye, Meijun
AU  - Ye M
AD  - Hangzhou Tea Research Institute, China COOP, Hangzhou, Zhejiang 310016, China.
FAU - Yan, Peng
AU  - Yan P
AD  - Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang 
      Province, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, 
      Zhejiang 315010, China.
FAU - Guo, Yanbo
AU  - Guo Y
AD  - Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang 
      Province, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, 
      Zhejiang 315010, China.
FAU - Zhang, Dandan
AU  - Zhang D
AD  - Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang 
      Province, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, 
      Zhejiang 315010, China.
FAU - He, Qian
AU  - He Q
AD  - National Institute of Occupational Health and Poison Control, Chinese Center for 
      Disease Control and Prevention, Beijing 100050, China. Electronic address: 
      heqian0216@163.com.
LA  - eng
PT  - Journal Article
DEP - 20231215
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 4632WW1X5A (Glyphosate)
RN  - 0 (Nanotubes, Carbon)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
SB  - IM
MH  - *Glyphosate
MH  - *Nanotubes, Carbon/chemistry
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
MH  - Limit of Detection
MH  - Solid Phase Extraction/methods
MH  - Chromatography, High Pressure Liquid/methods
OTO - NOTNLM
OT  - Poisoning confirmation
OT  - Solid-phase extraction
OT  - Trace analysis
OT  - UPLC-HRMS
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/25 00:42
MHDA- 2024/01/22 06:42
CRDT- 2023/12/24 18:02
PHST- 2023/09/30 00:00 [received]
PHST- 2023/11/24 00:00 [revised]
PHST- 2023/12/14 00:00 [accepted]
PHST- 2024/01/22 06:42 [medline]
PHST- 2023/12/25 00:42 [pubmed]
PHST- 2023/12/24 18:02 [entrez]
AID - S0021-9673(23)00806-3 [pii]
AID - 10.1016/j.chroma.2023.464581 [doi]
PST - ppublish
SO  - J Chromatogr A. 2024 Jan 25;1715:464581. doi: 10.1016/j.chroma.2023.464581. Epub 
      2023 Dec 15.