PMID- 38142685
OWN - NLM
STAT- MEDLINE
DCOM- 20240417
LR  - 20240417
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 185
IP  - 4
DP  - 2024
TI  - Associations between Total Immunoglobulin E Levels and Urinary Albumin Excretion: 
      A Cross-Sectional Study.
PG  - 311-319
LID - 10.1159/000535578 [doi]
AB  - INTRODUCTION: The association between total immunoglobulin E (IgE) levels and 
      urinary albumin excretion has not been fully established. Current study aimed to 
      evaluate the association between total IgE levels and urinary 
      albumin-to-creatinine ratio (UACR) among adult Americans. METHODS: Current 
      cross-sectional study utilized data from the 2005 to 2006 National Health and 
      Nutrition Examination Survey, including individuals aged 20 years and above. To 
      assess the relationships between total IgE levels and UACR, both multivariable 
      linear regression models and smooth curve fitting were employed. RESULTS: The 
      study included a total of 3,400 participants (weighted mean age: 46.6 +/- 0.8 
      years), with 1,625 females (weighted percentage: 47.8%). After adjusting for 
      potential confounders, we observed a positive association between higher total 
      IgE levels on a log2 scale and increased UACR (beta = 3.34; 95% CI: 1.40-5.28, p = 
      0.002). Furthermore, the association displayed a non-linear dose-response 
      pattern. The interaction test revealed a significant distinction in the 
      correlation between total IgE and UACR when stratified by hyperlipidemia (p for 
      interaction <0.001). The results remained robust in sensitivity analyses. 
      CONCLUSION: Our study revealed a significant and independent association between 
      elevated total IgE levels and an increased UACR, which also exhibited a distinct 
      non-linear pattern, highlighting the intricate nature of the connection between 
      IgE levels and UACR.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Pediatrics, The First Affiliated Hospital of Xiamen University, 
      Xiamen, China.
AD  - Pediatric Key Laboratory of Xiamen, Xiamen, China.
AD  - Institute of Pediatrics School of Medicine, Xiamen University, Xiamen, China.
FAU - Zhu, Baoping
AU  - Zhu B
AD  - Research Center for Translational Medicine, The First Affiliated Hospital of 
      Xiamen University, Xiamen, China.
FAU - Liu, Ye
AU  - Liu Y
AD  - Department of Pediatrics, The First Affiliated Hospital of Xiamen University, 
      Xiamen, China.
AD  - Pediatric Key Laboratory of Xiamen, Xiamen, China.
AD  - Institute of Pediatrics School of Medicine, Xiamen University, Xiamen, China.
FAU - Bai, Haitao
AU  - Bai H
AD  - Department of Pediatrics, The First Affiliated Hospital of Xiamen University, 
      Xiamen, China.
AD  - Pediatric Key Laboratory of Xiamen, Xiamen, China.
AD  - Institute of Pediatrics School of Medicine, Xiamen University, Xiamen, China.
LA  - eng
PT  - Journal Article
DEP - 20231222
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Albumins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - United States
MH  - Middle Aged
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - *Albumins
MH  - *Immunoglobulin E
OTO - NOTNLM
OT  - Albuminuria
OT  - Chronic kidney disease
OT  - National Health and Nutrition Examination Survey
OT  - Total immunoglobulin E
OT  - Urinary albumin-to-creatinine ratio
EDAT- 2023/12/25 00:42
MHDA- 2024/04/17 06:42
CRDT- 2023/12/24 18:27
PHST- 2023/10/10 00:00 [received]
PHST- 2023/11/27 00:00 [accepted]
PHST- 2024/04/17 06:42 [medline]
PHST- 2023/12/25 00:42 [pubmed]
PHST- 2023/12/24 18:27 [entrez]
AID - 000535578 [pii]
AID - 10.1159/000535578 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2024;185(4):311-319. doi: 10.1159/000535578. Epub 2023 
      Dec 22.