PMID- 38142920
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240225
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 119
IP  - 2
DP  - 2024 Feb
TI  - Fruit, berry, and vegetable consumption and the risk of islet autoimmunity and 
      type 1 diabetes in children-the Type 1 Diabetes Prediction and Prevention birth 
      cohort study.
PG  - 537-545
LID - S0002-9165(23)66347-6 [pii]
LID - 10.1016/j.ajcnut.2023.12.014 [doi]
AB  - BACKGROUND: Prospective studies investigating the association among fruit, berry, 
      and vegetable consumption and the risk of islet autoimmunity (IA) and type 1 
      diabetes (T1D) are few. OBJECTIVES: In this cohort study, we explored whether the 
      consumption of fruits, berries, and vegetables is associated with the IA and T1D 
      development in genetically susceptible children. METHODS: Food consumption data 
      in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) cohort study were 
      available from 5674 children born between September 1996 and September 2004 in 
      the Oulu and Tampere University Hospitals. Diet was assessed with 3-d food 
      records at the age of 3 and 6 mo and annually from 1 to 6 y. The association 
      between food consumption and the risk of IA and T1D was analyzed using joint 
      models adjusted for energy intake, sex, human leukocyte antigen (HLA) genotype, 
      and a family history of diabetes. RESULTS: During the 6-y follow-up, 247 children 
      (4.4%) developed IA and 94 (1.7%) T1D. Furthermore, 64 of 505 children with at 
      least 1 repeatedly positive autoantibody (12.7%) progressed from islet 
      autoantibody positivity to T1D. The consumption of cruciferous vegetables was 
      associated with decreased risk of IA [hazard ratio (HR): 0.83; 95% credible 
      intervals (CI): 0.72, 0.95, per 1 g/MJ increase in consumption] and the 
      consumption of berries with decreased risk of T1D (0.60; 0.47, 0.89). The 
      consumption of banana was associated with increased risk of IA (1.08; 1.04, 1.12) 
      and T1D (1.11; 1.01, 1.21). Only the association between banana and IA remain 
      significant after multiple testing correction. CONCLUSIONS: In children 
      genetically at risk for T1D, the consumption of cruciferous vegetables was 
      associated with decreased risk of IA and consumption of berries with decreased 
      risk of T1D. In addition, the consumption of banana was associated with increased 
      risk of IA and T1D.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Mattila, Markus
AU  - Mattila M
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for 
      Health and Welfare, Helsinki, Finland. Electronic address: 
      markus.mattila@tuni.fi.
FAU - Takkinen, Hanna-Mari
AU  - Takkinen HM
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for 
      Health and Welfare, Helsinki, Finland.
FAU - Peltonen, Essi J
AU  - Peltonen EJ
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland.
FAU - Vuorinen, Anna-Leena
AU  - Vuorinen AL
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for 
      Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland 
      (FIMM), University of Helsinki, Helsinki, Finland.
FAU - Niinisto, Sari
AU  - Niinisto S
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for 
      Health and Welfare, Helsinki, Finland.
FAU - Metsala, Johanna
AU  - Metsala J
AD  - Department of Public Health and Welfare, Finnish Institute for Health and 
      Welfare, Helsinki, Finland.
FAU - Ahonen, Suvi
AU  - Ahonen S
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for 
      Health and Welfare, Helsinki, Finland.
FAU - Akerlund, Mari
AU  - Akerlund M
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for 
      Health and Welfare, Helsinki, Finland.
FAU - Hakola, Leena
AU  - Hakola L
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland.
FAU - Toppari, Jorma
AU  - Toppari J
AD  - Institute of Biomedicine, Research Centre for Integrative Physiology and 
      Pharmacology, and Centre for Population Health Research, University of Turku, 
      Turku, Finland; Turku University Hospital, Department of Pediatrics, Turku, 
      Finland.
FAU - Ilonen, Jorma
AU  - Ilonen J
AD  - Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, 
      Finland.
FAU - Veijola, Riitta
AU  - Veijola R
AD  - Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, 
      University of Oulu, Oulu, Finland; Oulu University Hospital, Department of 
      Children and Adolescents, Oulu, Finland.
FAU - Haahtela, Tari
AU  - Haahtela T
AD  - Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
FAU - Knip, Mikael
AU  - Knip M
AD  - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, 
      University of Helsinki, Helsinki, Finland; Tampere University Hospital, 
      Department of Pediatrics, Tampere, Finland.
FAU - Virtanen, Suvi M
AU  - Virtanen SM
AD  - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, 
      Finland; Tampere University Hospital, Wellbeing Services County of Pirkanmaa, 
      Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for 
      Health and Welfare, Helsinki, Finland; Center for Child Health Research, Tampere 
      University and Tampere University Hospital, Tampere, Finland.
LA  - eng
PT  - Journal Article
DEP - 20231223
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Child
MH  - Humans
MH  - Infant
MH  - *Diabetes Mellitus, Type 1/etiology/genetics
MH  - Autoimmunity/genetics
MH  - Fruit
MH  - Cohort Studies
MH  - Vegetables
MH  - Prospective Studies
MH  - *Islets of Langerhans
MH  - Autoantibodies
PMC - PMC10884602
OTO - NOTNLM
OT  - berries
OT  - child
OT  - cohort study
OT  - fruits
OT  - islet autoimmunity
OT  - joint models
OT  - type 1 diabetes
OT  - vegetables
EDAT- 2023/12/25 00:42
MHDA- 2024/02/05 06:42
PMCR- 2023/12/23
CRDT- 2023/12/24 19:29
PHST- 2023/04/24 00:00 [received]
PHST- 2023/11/30 00:00 [revised]
PHST- 2023/12/19 00:00 [accepted]
PHST- 2024/02/05 06:42 [medline]
PHST- 2023/12/25 00:42 [pubmed]
PHST- 2023/12/24 19:29 [entrez]
PHST- 2023/12/23 00:00 [pmc-release]
AID - S0002-9165(23)66347-6 [pii]
AID - 10.1016/j.ajcnut.2023.12.014 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2024 Feb;119(2):537-545. doi: 10.1016/j.ajcnut.2023.12.014. Epub 
      2023 Dec 23.