PMID- 38145048
OWN - NLM
STAT- MEDLINE
DCOM- 20231226
LR  - 20240222
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 13
DP  - 2023
TI  - Bibliometric analysis of global research trends in adeno-associated virus vector 
      for gene therapy (1991-2022).
PG  - 1301915
LID - 10.3389/fcimb.2023.1301915 [doi]
LID - 1301915
AB  - BACKGROUND: Gene therapy involves introducing and editing foreign genes in the 
      body to treat and prevent genetic diseases. Adeno-associated virus (AAV) vector 
      has become a widely used tool in gene therapy due to its high safety and 
      transfection efficiency. METHODS: This study employs bibliometric analysis to 
      explore the foundation and current state of AAV vector application in gene 
      therapy research. A total of 6,069 publications from 1991 to 2022 were analyzed, 
      retrieved from the Science Citation Index Expanded (SCI-E) within the Web of 
      Science Core Collection (WoSCC) of Clarivate Analytics. Institutions, authors, 
      journals, references, and keywords were analyzed and visualized by using 
      VOSviewer and CiteSpace. The R language and Microsoft Excel 365 were used for 
      statistical analyses. RESULTS: The global literature on AAV vector and gene 
      therapy exhibited consistent growth, with the United States leading in 
      productivity, contributing 3,868 papers and obtaining the highest H-index. 
      Noteworthy authors like Wilson JM, Samulski RJ, Hauswirth WW, and Mingozzi F were 
      among the top 10 most productive and co-cited authors. The journal "Human Gene 
      Therapy" published the most papers (n = 485) on AAV vector and gene therapy. 
      Current research focuses on "gene editing," "gene structure," "CRISPR," and "AAV 
      gene therapy for specific hereditary diseases." CONCLUSION: The application of 
      AAV vector in gene therapy has shown continuous growth, fostering international 
      cooperation among countries and institutions. The intersection of gene editing, 
      gene structure, CRISPR, and AAV gene therapy for specific hereditary diseases and 
      AAV vector represents a prominent and prioritized focus in contemporary gene 
      therapy research. This study provides valuable insights into the trends and 
      characteristics of AAV gene therapy research, facilitating further advancements 
      in the field.
CI  - Copyright (c) 2023 Jiang, Zhang, Liu, Liu, Huang, Tan and Qin.
FAU - Jiang, Fengqi
AU  - Jiang F
AD  - Jinan University, Guangzhou, China.
FAU - Zhang, Chuanhe
AU  - Zhang C
AD  - Jinan University, Guangzhou, China.
FAU - Liu, Weina
AU  - Liu W
AD  - Jinan University, Guangzhou, China.
FAU - Liu, Fangyuan
AU  - Liu F
AD  - Jinan University, Guangzhou, China.
FAU - Huang, Haiyan
AU  - Huang H
AD  - Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
FAU - Tan, Yao
AU  - Tan Y
AD  - Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
AD  - Shenzhen Aier Ophthalmic Technology Institute, Shenzhen, China.
FAU - Qin, Bo
AU  - Qin B
AD  - Jinan University, Guangzhou, China.
AD  - Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
AD  - Shenzhen Aier Ophthalmic Technology Institute, Shenzhen, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231208
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
SB  - IM
MH  - Humans
MH  - *Dependovirus/genetics
MH  - *Bibliometrics
MH  - Clustered Regularly Interspaced Short Palindromic Repeats
MH  - Gene Editing
MH  - Genetic Therapy
PMC - PMC10739348
OTO - NOTNLM
OT  - adeno-associated virus
OT  - bibliometric
OT  - gene therapy
OT  - inherited diseases
OT  - research trends
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/12/25 06:43
MHDA- 2023/12/26 06:41
PMCR- 2023/01/01
CRDT- 2023/12/25 04:49
PHST- 2023/09/25 00:00 [received]
PHST- 2023/11/20 00:00 [accepted]
PHST- 2023/12/26 06:41 [medline]
PHST- 2023/12/25 06:43 [pubmed]
PHST- 2023/12/25 04:49 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fcimb.2023.1301915 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2023 Dec 8;13:1301915. doi: 
      10.3389/fcimb.2023.1301915. eCollection 2023.