PMID- 38146348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231227
IS  - 2052-2975 (Print)
IS  - 2052-2975 (Electronic)
IS  - 2052-2975 (Linking)
VI  - 56
DP  - 2024 Jan
TI  - Clinicopathological characteristics of 3 probable pediatric cases with acute 
      severe hepatitis of unknown aetiology.
PG  - 101203
LID - 10.1016/j.nmni.2023.101203 [doi]
LID - 101203
AB  - BACKGROUND: Acute severe hepatitis with unknown aetiology in children (ASHep-UA) 
      has become a global health alert. This article reported clinicopathological 
      characteristics of 3 probable ASHep-UA cases. METHODS: We respectively collected 
      serological data and liver biopsies of 3 suspected cases of ASHep-UA. 
      Neutralizing antibodies titer for severe acute respiratory syndrome coronavirus 2 
      (SARS-CoV-2) Omicron variants were determined by virus neutralization test (VNT). 
      Histological assessment, immunohistochemistry (IHC) and fluorescence in situ 
      hybridization (FISH) for cytomegalovirus (CMV), Epstein-Barr virus (EBV), human 
      adenoviruses (HAdV), adeno-associated virus (AAV2), human herpes virus type 6 
      (HHV-6) were performed to identify possible aetiologies. RESULTS: Remarkable 
      elevation of transaminase (median ALT level, 1100 IU/liter; median AST level, 500 
      IU/liter) were revealed with undetectable hepatitis A-E and non-hepatotropic 
      virus in both sera and tissues. Weakness, jaundice, pale stools and splenomegaly 
      were observed. Interestingly, two individuals had SARS-CoV-2 Omicron variants 
      infection. Histologically, moderate or severe lobular necroinflammation, active 
      interface hepatitis and portal inflammatory infiltrate with lymphocytic, plasma 
      cells, neutrophils and eosinophilic cells were noted. CONCLUSIONS: The exact 
      aetiology of ASHep-UA was still unknown. By reporting the 3 probable cases, we 
      expect to enrich the clinical experience in diagnosis and treatment of ASHep-UA 
      as well as the pathological characteristics.
CI  - (c) 2023 The Authors. Published by Elsevier Ltd.
FAU - Li, Meiling
AU  - Li M
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Jiang, Lina
AU  - Jiang L
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Liu, Shuhong
AU  - Liu S
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Xu, Pengfei
AU  - Xu P
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Wei, Haiyan
AU  - Wei H
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Li, Yu
AU  - Li Y
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Guo, Chaonan
AU  - Guo C
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Zhu, Li
AU  - Zhu L
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Zhao, Bokang
AU  - Zhao B
AD  - Department of Hepatology, Center of Infectious Diseases and PathogenBiology, The 
      First Hospital of Jilin University, Changchun, China.
FAU - Liu, Yisi
AU  - Liu Y
AD  - First Department of Liver Disease Center, Beijing Youan Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Min
AU  - Zhang M
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
FAU - Zhao, Jingmin
AU  - Zhao J
AD  - The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - England
TA  - New Microbes New Infect
JT  - New microbes and new infections
JID - 101624750
PMC - PMC10749268
OTO - NOTNLM
OT  - Acute severe hepatitis
OT  - Children
OT  - Clinicopathological characteristics
OT  - Unknown aetiology
COIS- The authors declare no conflicts of interest, financial or otherwise to this 
      work.
EDAT- 2023/12/26 06:41
MHDA- 2023/12/26 06:42
PMCR- 2023/12/01
CRDT- 2023/12/26 03:38
PHST- 2023/08/18 00:00 [received]
PHST- 2023/11/13 00:00 [revised]
PHST- 2023/11/22 00:00 [accepted]
PHST- 2023/12/26 06:42 [medline]
PHST- 2023/12/26 06:41 [pubmed]
PHST- 2023/12/26 03:38 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - S2052-2975(23)00122-1 [pii]
AID - 101203 [pii]
AID - 10.1016/j.nmni.2023.101203 [doi]
PST - epublish
SO  - New Microbes New Infect. 2023 Dec 1;56:101203. doi: 10.1016/j.nmni.2023.101203. 
      eCollection 2024 Jan.