PMID- 38147163 OWN - NLM STAT- MEDLINE DCOM- 20231227 LR - 20240205 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 28 IP - 1 DP - 2023 Dec 26 TI - The association of aldehyde exposure with the risk of periodontitis: NHANES 2013-2014. PG - 29 LID - 10.1007/s00784-023-05451-y [doi] AB - OBJECTIVES: Three distinct models were utilized to investigate the combined impacts of serum aldehyde exposure and periodontitis. MATERIALS AND METHODS: We performed a cross-sectional analysis using data from 525 participants in the 2013-2014 National Health and Nutrition Examination Survey (NHANES). The directed acyclic graphs (DAG) were used to select a minimal sufficient adjustment set of variables (MSAs). To investigate the relationship between aldehydes and periodontitis, we established three models including multiple logistic regression model, restricted cubic spline (RCS) model, and Bayesian kernel machine regression (BKMR) model. RESULTS: After taking all covariates into account, the multiple logistic regression model revealed that elevated concentrations of isopentanaldehyde and propanaldehyde were strongly associated with periodontitis (isopentanaldehyde: OR: 2.38, 95% CI: 1.34-4.23; propanaldehyde: OR: 1.51, 95% CI: 1.08-2.13). Furthermore, the third tertile concentration of isopentanaldehyde was associated with a 2.04-fold increase in the incidence of periodontitis (95% CI: 1.05-3.95) compared to the first tertile concentration, with a P for trend = 0.04. RCS models showed an "L"-shaped relationship between isopentanaldehyde and periodontitis (P for nonlinear association < 0.01), with inflection point of 0.43 ng/mL. BKMR identified a strong connection between mixed aldehydes and periodontitis, with isopentanaldehyde exhibiting the greatest posterior inclusion probability (PIP) with 0.901 and propanaldehyde exhibiting a PIP with 0.775. CONCLUSIONS: Isopentanaldehyde and propanaldehyde are positively associated with the risk of periodontitis. CLINICAL RELEVANCE: Periodontitis may be associated with exposure to mixed aldehyde. This study emphasizes the important role of aldehydes in primary prevention of periodontitis. CI - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Cui, Xing AU - Cui X AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. FAU - Zhu, Guirong AU - Zhu G AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. FAU - Lin, Junyan AU - Lin J AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. FAU - Chu, Catherine Huihan AU - Chu CH AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. FAU - Li, Kang AU - Li K AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. FAU - Fan, Liwen AU - Fan L AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. FAU - Xing, Changyue AU - Xing C AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. FAU - Wang, Lin AU - Wang L AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. lw603@njmu.edu.cn. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. lw603@njmu.edu.cn. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. lw603@njmu.edu.cn. AD - State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 210029, China. lw603@njmu.edu.cn. FAU - Pan, Yongchu AU - Pan Y AD - Department of Orthodontics, The Affiliated Stomatology Hospital of Nanjing Medical University, Nanjing, 210029, China. panyongchu@njmu.edu.cn. AD - Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China. panyongchu@njmu.edu.cn. AD - Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China. panyongchu@njmu.edu.cn. AD - State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 210029, China. panyongchu@njmu.edu.cn. LA - eng GR - 81830031/National Natural Science Foundation of China/ GR - 81830031/National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20231226 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 RN - 0 (Aldehydes) MH - Humans MH - Bayes Theorem MH - Cross-Sectional Studies MH - Nutrition Surveys MH - *Aldehydes/adverse effects MH - *Periodontitis/epidemiology OTO - NOTNLM OT - Aldehydes OT - Bayesian kernel machine regression OT - Logistic models OT - NHANES OT - Periodontitis OT - Restricted cubic spline EDAT- 2023/12/26 12:42 MHDA- 2023/12/27 06:41 CRDT- 2023/12/26 11:07 PHST- 2023/09/04 00:00 [received] PHST- 2023/12/17 00:00 [accepted] PHST- 2023/12/27 06:41 [medline] PHST- 2023/12/26 12:42 [pubmed] PHST- 2023/12/26 11:07 [entrez] AID - 10.1007/s00784-023-05451-y [pii] AID - 10.1007/s00784-023-05451-y [doi] PST - epublish SO - Clin Oral Investig. 2023 Dec 26;28(1):29. doi: 10.1007/s00784-023-05451-y.