PMID- 38147391
OWN - NLM
STAT- MEDLINE
DCOM- 20240220
LR  - 20240220
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 123
IP  - 12
DP  - 2023
TI  - [Polymorphisms of OPRM1, OPRK1, DCC genes and non-suicidal self-injuries in 
      adults].
PG  - 116-123
LID - 10.17116/jnevro2023123121116 [doi]
AB  - OBJECTIVE: To investigate the associations of OPRM1 gene rs179971, OPRK1 gene 
      rs6473797 and DCC gene rs8084280 polymorphisms with non-suicidal self-injury 
      (NSSI) characteristics and motivations in adults. MATERIAL AND METHODS: A pilot 
      sample included 28 adult patients with history of NSSI (89.3% (n=25) women, 
      median age (Q(1)-Q(3)) - 23 (21.25-25) years). Most patients (78.6%, n=20) had a 
      diagnosis of bipolar disorder. NSSI characteristics and motivations were assessed 
      using the Inventory of Statements about Self-Injury (ISAS) scale. The Childhood 
      Trauma Questionnaire (CTQ) was used to control for childhood trauma - one of the 
      most important environmental factors associated with NSSI. The Baratt Impulsivity 
      Scale (BIS) and the Buss-Perry Aggression Questionnaire (BPAQ) were also used to 
      assess impulsivity and aggression, respectively. RT-PCR was used for genotyping, 
      a genetic effect was assessed using the dominant model. Mann-Whitney U-test, 
      Pearson chi(2)-test and multiple linear regression were used for statistical 
      analysis. RESULTS: Carriers of the minor G allele of OPRM1 gene rs1779971 had a 
      higher level of aggression assessed by BPAQ (p=0.02). The minor C allele of OPRK1 
      gene rs6473797 was associated with an increase of the subjective importance of 
      <<Affect regulation>> (B=2.23; CI 95% [0.39-4.06]; p=0.022) and <<Anti-dissociation>> 
      (B=3.31; CI 95% [0.18-6.44]; p=0.039) motivations, whereas the minor T allele of 
      DCC gene rs8084280, on the contrary, was associated with a decrease of the 
      importance of <<Affect regulation>> (B=-1.74; CI 95% [-3.30 - -0.18]; p=0.032). 
      Moreover, this effect was found after adjusting for diagnosis, sex, age, and the 
      presence of childhood trauma. CONCLUSIONS: To our knowledge, this is the first 
      study on the association of genetic markers with NSSI motivations. The results of 
      this pilot study demonstrate that OPRK1 and DCC gene polymorphisms can determine 
      differences in motivations for self-harm, however, these results require 
      confirmation in large samples.
FAU - Kibitov, A A
AU  - Kibitov AA
AUID- ORCID: 0000-0001-7766-9675
AD  - Mental Health Research Center, Moscow, Russia.
AD  - Bekhterev National Medical Research Center for Psychiatry and Neurology, 
      St-Petersburg, Russia.
FAU - Merkulova, T V
AU  - Merkulova TV
AUID- ORCID: 0000-0001-5880-726X
AD  - Serbsky National Medical Research Centre on Psychiatry and Addictions, Moscow, 
      Russia.
FAU - Mazo, G E
AU  - Mazo GE
AUID- ORCID: 0000-0001-7910-9129
AD  - Bekhterev National Medical Research Center for Psychiatry and Neurology, 
      St-Petersburg, Russia.
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Polimorfizmy genov OPRM1, OPRK1 i DCC i nesuitsidal'nye samopovrezhdeniya u 
      vzroslykh.
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - 0 (OPRM1 protein, human)
RN  - 0 (Receptors, Opioid, mu)
RN  - 0 (OPRK1 protein, human)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 0 (DCC protein, human)
RN  - 0 (DCC Receptor)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - *Receptors, Opioid, mu/genetics/metabolism
MH  - *Receptors, Opioid, kappa/genetics/metabolism
MH  - *DCC Receptor/genetics/metabolism
MH  - *Self-Injurious Behavior/genetics
MH  - Humans
MH  - Male
MH  - Female
MH  - Young Adult
MH  - Adult
MH  - Genetic Markers/genetics
MH  - Surveys and Questionnaires
MH  - Impulsive Behavior
MH  - Aggression
MH  - *Polymorphism, Genetic/genetics
OTO - NOTNLM
OT  - genetics
OT  - non-suicidal self-injury
OT  - self-harm
EDAT- 2023/12/26 12:42
MHDA- 2023/12/27 06:42
CRDT- 2023/12/26 11:54
PHST- 2023/12/27 06:42 [medline]
PHST- 2023/12/26 12:42 [pubmed]
PHST- 2023/12/26 11:54 [entrez]
AID - 10.17116/jnevro2023123121116 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(12):116-123. doi: 
      10.17116/jnevro2023123121116.