PMID- 38147413
OWN - NLM
STAT- Publisher
LR  - 20231226
IS  - 1872-6623 (Electronic)
IS  - 0304-3959 (Linking)
DP  - 2023 Dec 22
TI  - Increased risk of persistent neuropathic pain after traumatic nerve injury and 
      surgery for carriers of a human leukocyte antigen haplotype.
LID - 10.1097/j.pain.0000000000003143 [doi]
AB  - It is not known why some patients develop persistent pain after nerve trauma 
      while others do not. Among multiple risk factors for the development of 
      persistent posttrauma and postsurgical pain, a neuropathic mechanism due to 
      iatrogenic nerve lesion has been proposed as the major cause of these conditions. 
      Because there is some evidence that the human leukocyte antigen (HLA) system 
      plays a role in persistent postsurgical pain, this study aimed to identify the 
      genetic risk factors, specifically among HLA loci, associated with chronic 
      neuropathic pain after traumatic nerve injuries and surgery in the upper 
      extremities. Blood samples were taken to investigate the contribution of HLA 
      alleles (ie, HLA-A, HLA-B, HLA-DRB1, HLA-DQB1, and HLA-DPB1) in a group of 
      patients with persistent neuropathic pain (n = 70) and a group of patients with 
      neuropathy without pain (n = 61). All subjects had intraoperatively verified 
      nerve damage in the upper extremity. They underwent bedside clinical neurological 
      examination to identify the neuropathic pain component according to the present 
      grading system of neuropathic pain. Statistical analyses on the allele and 
      haplotype were conducted using the BIGDAWG package. We found that the HLA 
      haplotype A*02:01-B*15:01-C*03:04-DRB1*04:01-DQB1*03:02 was associated with an 
      increased risk of developing persistent neuropathic pain in the upper extremity 
      (OR = 9.31 [95% CI 1.28-406.45], P < 0.05). No significant associations were 
      found on an allele level when correcting for multiple testing. Further studies 
      are needed to investigate whether this association is on a haplotypic level or if 
      certain alleles may be causing the association.
CI  - Copyright (c) 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the International Association for the Study of Pain.
FAU - Miclescu, Adriana
AU  - Miclescu A
AUID- ORCID: 0000-0001-5680-3388
AD  - Departments of Surgical Sciences and.
FAU - Ronngren, Clara
AU  - Ronngren C
AD  - Departments of Surgical Sciences and.
FAU - Bengtsson, Mats
AU  - Bengtsson M
AD  - Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
FAU - Gordh, Torsten
AU  - Gordh T
AD  - Departments of Surgical Sciences and.
FAU - Hedin, Anders
AU  - Hedin A
AD  - Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
LA  - eng
SI  - ClinicalTrials.gov/NCT03174665
PT  - Journal Article
DEP - 20231222
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
SB  - IM
EDAT- 2023/12/26 18:41
MHDA- 2023/12/26 18:41
CRDT- 2023/12/26 12:23
PHST- 2023/06/02 00:00 [received]
PHST- 2023/10/21 00:00 [accepted]
PHST- 2023/12/26 18:41 [medline]
PHST- 2023/12/26 18:41 [pubmed]
PHST- 2023/12/26 12:23 [entrez]
AID - 00006396-990000000-00483 [pii]
AID - 10.1097/j.pain.0000000000003143 [doi]
PST - aheadofprint
SO  - Pain. 2023 Dec 22. doi: 10.1097/j.pain.0000000000003143.