PMID- 38150946
OWN - NLM
STAT- MEDLINE
DCOM- 20240202
LR  - 20240221
IS  - 1879-2219 (Electronic)
IS  - 0966-6362 (Print)
IS  - 0966-6362 (Linking)
VI  - 108
DP  - 2024 Feb
TI  - Minimal clinically important differences of spatiotemporal gait variables in 
      Parkinson disease.
PG  - 257-263
LID - S0966-6362(23)01496-0 [pii]
LID - 10.1016/j.gaitpost.2023.11.016 [doi]
AB  - BACKGROUND: Assessment of gait function in People with Parkinson Disease (PwPD) 
      is an important tool for monitoring disease progression in PD. While 
      comprehensive gait analysis has become increasingly popular, only one study, Hass 
      et al. (2014), has established minimal clinically important differences (MCID) 
      for one spatiotemporal variable (velocity) in PwPD. RESEARCH QUESTION: What are 
      the MCIDs for velocity and additional spatiotemporal variables, including mean, 
      variability, and asymmetry of step length, time, and width? METHODS: As part of a 
      larger clinic-based initiative, 382 medicated, ambulatory PwPD walked on an 
      instrumented walkway during routine clinical visits. Distribution and 
      anchor-based methods (Unified Parkinson's Disease Rating Scale-III, Modified 
      Hoehn and Yahr, and the mobility subsection of the Parkinson Disease 
      Questionnaire) were used to calculate MCIDs for variables of interest in a 
      cross-sectional approach. RESULTS: Distribution measures for all variables are 
      presented. Of nine gait variables, four were significantly associated with every 
      anchor and pooled to the following values: velocity (8.2 cm/s), step length mean 
      (3.6 cm), step length variability (0.7%), and step time variability (0.67%). 
      SIGNIFICANCE: The finalized MCID for velocity (8.2 cm/s) was nearly half of the 
      MCID of 15 cm/s reported by Hass et al., potentially due to differences in 
      calculations. These results allow for evaluations of effectiveness of 
      interventions by providing values that are specific to changes in gait for PwPD. 
      Alterations of methodology including different versions of clinical or walking 
      assessments, and/or different calculation and selection of gait variables 
      necessitate careful reasoning when using presented MCIDs.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Baudendistel, Sidney T
AU  - Baudendistel ST
AD  - Program in Physical Therapy, Washington University School of Medicine in St. 
      Louis, United States.
FAU - Haussler, Allison M
AU  - Haussler AM
AD  - Program in Physical Therapy, Washington University School of Medicine in St. 
      Louis, United States.
FAU - Rawson, Kerri S
AU  - Rawson KS
AD  - Program in Physical Therapy, Washington University School of Medicine in St. 
      Louis, United States; Department of Neurology, Washington University School of 
      Medicine in St. Louis, United States.
FAU - Earhart, Gammon M
AU  - Earhart GM
AD  - Program in Physical Therapy, Washington University School of Medicine in St. 
      Louis, United States; Department of Neurology, Washington University School of 
      Medicine in St. Louis, United States; Department of Neuroscience, Washington 
      University School of Medicine in St. Louis, United States. Electronic address: 
      earhartg@wustl.edu.
LA  - eng
GR  - T32 HD007434/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20231125
PL  - England
TA  - Gait Posture
JT  - Gait & posture
JID - 9416830
SB  - IM
MH  - Humans
MH  - *Parkinson Disease/complications
MH  - Minimal Clinically Important Difference
MH  - Gait
MH  - Walking
MH  - Gait Analysis
PMC - PMC10878409
MID - NIHMS1963195
OTO - NOTNLM
OT  - Gait
OT  - MCID
OT  - Parkinson disease
COIS- Declaration of Competing Interest none.
EDAT- 2023/12/28 00:42
MHDA- 2024/02/02 06:43
PMCR- 2024/02/20
CRDT- 2023/12/27 18:11
PHST- 2023/07/19 00:00 [received]
PHST- 2023/10/18 00:00 [revised]
PHST- 2023/11/21 00:00 [accepted]
PHST- 2024/02/02 06:43 [medline]
PHST- 2023/12/28 00:42 [pubmed]
PHST- 2023/12/27 18:11 [entrez]
PHST- 2024/02/20 00:00 [pmc-release]
AID - S0966-6362(23)01496-0 [pii]
AID - 10.1016/j.gaitpost.2023.11.016 [doi]
PST - ppublish
SO  - Gait Posture. 2024 Feb;108:257-263. doi: 10.1016/j.gaitpost.2023.11.016. Epub 
      2023 Nov 25.