PMID- 38151728
OWN - NLM
STAT- MEDLINE
DCOM- 20231229
LR  - 20240106
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 45
IP  - 1
DP  - 2024 Jan 1
TI  - A case-control study for comorbidity and laboratory factors associated with 
      food-induced anaphylaxis.
PG  - 53-60
LID - 10.2500/aap.2024.45.230076 [doi]
AB  - Background: Food-induced anaphylaxis (FIA) is a serious and potentially 
      life-threatening allergic reaction triggered by food allergens. Objective: This 
      case-control study aimed to investigate comorbidities and laboratory factors 
      associated with FIA in the pediatric population of Israel. Methods: Retrospective 
      data from the electronic health records of Leumit Health Care Services were used 
      to identify 711 pediatric patients with FIA and 2560 subjects with food allergy 
      and without anaphylaxis matched for age, gender, and ethnicity. Comorbidities 
      were identified based on medical billing diagnosis codes, and laboratory 
      characteristics were compared between the two groups. Results: The mean +/- 
      standard deviation age of patients with FIA was 4.1 +/- 4.1 years, and 37.3% were 
      girls. Laboratory analysis revealed increased eosinophil counts (p < 0.001), 
      elevated immunoglobulin E (IgE) (p < 0.001), and IgA levels (p = 0.001) in the 
      FIA group compared with the controls. With regard to comorbidities, the FIA group 
      had higher prevalence rates of allergic diseases, including allergic rhinitis 
      (odds ratio [OR] 1.72; p < 0.001), allergic conjunctivitis (OR 1.84; p = 0.001), 
      asthma (OR 1.36; p < 0.001), angioedema (OR 6.37; p < 0.001), atopic dermatitis 
      (OR 1.77; p < 0.001), and contact dermatitis (OR 1.42; p = 0.001). There was a 
      trend toward significance for chronic spontaneous urticaria (p = 0.051). There 
      was a significant negative association between helminthiases, particularly 
      enterobiasis, and FIA (OR 0.76 [95% confidence interval, 0.59-0.98]; p = 0.029). 
      Conclusion: This study provides valuable epidemiologic evidence on the 
      associations among FIA, comorbidities, and laboratory factors in the pediatric 
      population.
FAU - Magen, Eli
AU  - Magen E
AD  - From the Leumit Health Services, Tel Aviv-Yafo, Israel.
FAU - Merzon, Eugene
AU  - Merzon E
AD  - From the Leumit Health Services, Tel Aviv-Yafo, Israel.
FAU - Green, Ilan
AU  - Green I
AD  - From the Leumit Health Services, Tel Aviv-Yafo, Israel.
FAU - Golan-Cohen, Avivit
AU  - Golan-Cohen A
AD  - From the Leumit Health Services, Tel Aviv-Yafo, Israel.
FAU - Magen, Israel
AU  - Magen I
AD  - Medicine A Department, Assuta Ashdod University Hospital Faculty of Health 
      Sciences, Ben-Gurion University, Beer-Sheba, Israel.
FAU - Vinker, Shlomo
AU  - Vinker S
AD  - From the Leumit Health Services, Tel Aviv-Yafo, Israel.
FAU - Israel, Ariel
AU  - Israel A
AD  - From the Leumit Health Services, Tel Aviv-Yafo, Israel.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
SB  - IM
MH  - Female
MH  - Humans
MH  - Child
MH  - Infant, Newborn
MH  - Infant
MH  - Child, Preschool
MH  - Male
MH  - *Anaphylaxis/epidemiology/etiology
MH  - Case-Control Studies
MH  - Retrospective Studies
MH  - Allergens
MH  - *Food Hypersensitivity/epidemiology
MH  - Comorbidity
EDAT- 2023/12/28 00:42
MHDA- 2023/12/29 06:43
CRDT- 2023/12/27 23:43
PHST- 2023/12/29 06:43 [medline]
PHST- 2023/12/28 00:42 [pubmed]
PHST- 2023/12/27 23:43 [entrez]
AID - 10.2500/aap.2024.45.230076 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2024 Jan 1;45(1):53-60. doi: 10.2500/aap.2024.45.230076.