PMID- 38153510
OWN - NLM
STAT- MEDLINE
DCOM- 20231229
LR  - 20240205
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 28
IP  - 1
DP  - 2023 Dec 28
TI  - Efficacy of injectable platelet-rich fibrin on clinical and biochemical 
      parameters in non-surgical periodontal treatment: a split-mouth randomized 
      controlled trial.
PG  - 46
LID - 10.1007/s00784-023-05447-8 [doi]
AB  - OBJECTIVES: The purpose of this clinical trial was to evaluate the potential 
      clinical and biochemical effects of injectable platelet-rich fibrin (i-PRF) 
      application adjunct to scaling and root planning (ScRp) in deep periodontal 
      pockets. MATERIALS AND METHODS: In this split-mouth-designed study, 17 patients 
      with 34 deep periodontal pockets were randomly treated with ScRp + i-PRF (test 
      group) and ScRp + saline (control group). Clinical periodontal measurements were 
      recorded at baseline, 1st, 3rd, and 6th months after the treatments. The levels 
      of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), 
      and interleukin (IL)-10 in gingival crevicular fluid (GCF) samples were analyzed 
      using the ELISA method at baseline, 7th, and 14th days. RESULTS: Clinical 
      periodontal parameters showed significant improvements with both treatment 
      modalities. Mean pocket reduction (PD) and clinical attachment (CAL) gain were 
      significantly higher in the test group than in controls at follow-up visits (p < 
      0.05). In the test group, gingival recession (GR) values were significantly lower 
      compared to the control group. VEGF and IL-10 levels in the test group were 
      significantly higher than in controls at the 14th day, and TNF-alpha levels were 
      found significantly lower in the test group at the 7th and 14th days. 
      CONCLUSIONS: Especially in the test group, the significant increase in VEGF and 
      IL-10 expressions and the decrease in TNF-alpha levels may have accelerated the 
      periodontal healing observed in the clinical parameters. CLINICAL RELEVANCE: The 
      result of the present study demonstrated the beneficial effects of adjunctive 
      i-PRF administration during non-surgical periodontal treatment of deep 
      periodontal pockets. CLINICAL TRIAL REGISTRATION NUMBER: NCT05753631.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Torumtay Cin, Gizem
AU  - Torumtay Cin G
AUID- ORCID: 0000-0002-5362-4146
AD  - Department of Periodontology, Faculty of Dentistry, Pamukkale University, 
      Denizli, Turkey. gyaprak_dt@hotmail.com.
FAU - Lektemur Alpan, Aysan
AU  - Lektemur Alpan A
AUID- ORCID: 0000-0002-5939-4783
AD  - Department of Periodontology, Faculty of Dentistry, Pamukkale University, 
      Denizli, Turkey.
FAU - Cevik, Ozge
AU  - Cevik O
AUID- ORCID: 0000-0002-9325-3757
AD  - Department of Medical Biochemistry, Faculty of Medicine, Adnan Menderes 
      University, Aydin, Turkey.
LA  - eng
SI  - ClinicalTrials.gov/NCT05753631
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20231228
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Tumor Necrosis Factor-alpha)
MH  - Humans
MH  - *Interleukin-10
MH  - Vascular Endothelial Growth Factor A
MH  - Periodontal Pocket
MH  - *Platelet-Rich Fibrin
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Cytokine
OT  - Nonsurgical periodontal debridement
OT  - Periodontitis
OT  - Platelet-rich fibrin
OT  - Regeneration
OT  - Vascular endothelial growth factor
EDAT- 2023/12/28 12:41
MHDA- 2023/12/29 06:43
CRDT- 2023/12/28 11:16
PHST- 2023/08/25 00:00 [received]
PHST- 2023/12/17 00:00 [accepted]
PHST- 2023/12/29 06:43 [medline]
PHST- 2023/12/28 12:41 [pubmed]
PHST- 2023/12/28 11:16 [entrez]
AID - 10.1007/s00784-023-05447-8 [pii]
AID - 10.1007/s00784-023-05447-8 [doi]
PST - epublish
SO  - Clin Oral Investig. 2023 Dec 28;28(1):46. doi: 10.1007/s00784-023-05447-8.