PMID- 38153856
OWN - NLM
STAT- MEDLINE
DCOM- 20240416
LR  - 20240416
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 42
IP  - 4
DP  - 2024 Apr 15
TI  - Human Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Alleviate 
      Hypoxia-Induced Pulmonary Arterial Hypertension in Mice Via Macrophages.
PG  - 329-345
LID - 10.1093/stmcls/sxad098 [doi]
AB  - Pulmonary hypertension (PH) is an intractable, severe, and progressive 
      cardiopulmonary disease. Recent findings suggest that human umbilical cord 
      mesenchymal stromal cells (HUCMSCs) and HUCMSC-derived exosomes (HUCMSC-Exos) 
      possess potential therapeutic value for PH. However, whether they have beneficial 
      effects on hypoxic pulmonary hypertension (HPH) is unclear. Exos are released 
      into the extracellular environment by the fusion of intracellular multivesicular 
      bodies with the cell membrane, and they play an important role in cellular 
      communication. Exos ameliorate immune inflammation levels, alter macrophage 
      phenotypes, regulate mitochondrial metabolic function, and inhibit pulmonary 
      vascular remodeling, thereby improving PH. Macrophages are important sources of 
      cytokines and other transmitters and can promote the release of cytokines, 
      vasoactive molecules, and reactive oxygen species, all of which are associated 
      with pulmonary vascular remodeling. Therefore, the aim of this study was to 
      investigate whether HUCMSC-Exos could improve the lung inflammatory 
      microenvironment and inhibit pulmonary vascular remodeling by targeting 
      macrophages and identifying the underlying mechanisms. The results showed that 
      HUCMSC-Exos promoted M2 macrophage polarization, decreased pro-inflammatory 
      factors, increased IL-10 levels, and inhibited IL-33/ST2 axis expression, thereby 
      inhibiting hypoxia-induced proliferation of pulmonary artery smooth muscle cells 
      and ameliorating HPH.
CI  - (c) The Author(s) 2023. Published by Oxford University Press. All rights reserved. 
      For permissions, please email: journals.permissions@oup.com.
FAU - Liu, Hong
AU  - Liu H
AUID- ORCID: 0009-0000-3559-525X
AD  - Research Centre for High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of the Ministry of High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of Applied Fundamentals of High Altitude Medicine, (Qinghai-Utah 
      Joint Key Laboratory of Plateau Medicine), XiNing, China.
AD  - Laboratory for High Altitude Medicine of Qinghai Province, XiNing, China.
FAU - Zhang, Qingqing
AU  - Zhang Q
AD  - Research Centre for High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of the Ministry of High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of Applied Fundamentals of High Altitude Medicine, (Qinghai-Utah 
      Joint Key Laboratory of Plateau Medicine), XiNing, China.
AD  - Laboratory for High Altitude Medicine of Qinghai Province, XiNing, China.
AD  - Affiliated Hospital of Qinghai University, Xining, QingHai, XiNing, China.
FAU - Liu, Chuanchuan
AU  - Liu C
AD  - Affiliated Hospital of Qinghai University, Xining, QingHai, XiNing, China.
FAU - Zhang, Yuwei
AU  - Zhang Y
AD  - Department of Public Health of Qinghai University, XiNing, China.
FAU - Wang, Yuxiang
AU  - Wang Y
AD  - Research Centre for High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of the Ministry of High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of Applied Fundamentals of High Altitude Medicine, (Qinghai-Utah 
      Joint Key Laboratory of Plateau Medicine), XiNing, China.
AD  - Laboratory for High Altitude Medicine of Qinghai Province, XiNing, China.
FAU - Huang, Pan
AU  - Huang P
AD  - Research Centre for High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of the Ministry of High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of Applied Fundamentals of High Altitude Medicine, (Qinghai-Utah 
      Joint Key Laboratory of Plateau Medicine), XiNing, China.
AD  - Laboratory for High Altitude Medicine of Qinghai Province, XiNing, China.
FAU - Ma, Lan
AU  - Ma L
AD  - Research Centre for High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of the Ministry of High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of Applied Fundamentals of High Altitude Medicine, (Qinghai-Utah 
      Joint Key Laboratory of Plateau Medicine), XiNing, China.
AD  - Laboratory for High Altitude Medicine of Qinghai Province, XiNing, China.
FAU - Ge, Rili
AU  - Ge R
AUID- ORCID: 0000-0002-4940-9697
AD  - Research Centre for High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of the Ministry of High Altitude Medicine, XiNing, China.
AD  - Key Laboratory of Applied Fundamentals of High Altitude Medicine, (Qinghai-Utah 
      Joint Key Laboratory of Plateau Medicine), XiNing, China.
AD  - Laboratory for High Altitude Medicine of Qinghai Province, XiNing, China.
LA  - eng
GR  - 32060207/National Natural Science Foundation of China/
PT  - Journal Article
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - *Pulmonary Arterial Hypertension/metabolism
MH  - *Hypertension, Pulmonary/etiology/therapy/metabolism
MH  - *Exosomes/metabolism
MH  - Vascular Remodeling
MH  - Umbilical Cord/metabolism
MH  - Hypoxia/complications/metabolism
MH  - Macrophages/metabolism
MH  - Cytokines/metabolism
MH  - *Mesenchymal Stem Cells/metabolism
OTO - NOTNLM
OT  - exosomes
OT  - hypoxic pulmonary hypertension
OT  - immune microenvironment
OT  - immunomodulation
OT  - mesenchymal stromal cells
OT  - pulmonary vascular remodeling
EDAT- 2023/12/28 18:42
MHDA- 2024/04/16 12:43
CRDT- 2023/12/28 13:02
PHST- 2023/07/26 00:00 [received]
PHST- 2023/12/01 00:00 [accepted]
PHST- 2024/04/16 12:43 [medline]
PHST- 2023/12/28 18:42 [pubmed]
PHST- 2023/12/28 13:02 [entrez]
AID - 7503315 [pii]
AID - 10.1093/stmcls/sxad098 [doi]
PST - ppublish
SO  - Stem Cells. 2024 Apr 15;42(4):329-345. doi: 10.1093/stmcls/sxad098.