PMID- 38154057
OWN - NLM
STAT- MEDLINE
DCOM- 20240222
LR  - 20240223
IS  - 2194-802X (Electronic)
IS  - 2194-802X (Linking)
VI  - 11
IP  - 1
DP  - 2024 Feb 1
TI  - Interleukin-6, tumor necrosis factor-alpha, and high-sensitivity C-reactive protein 
      for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk.
PG  - 82-90
LID - 10.1515/dx-2023-0159 [doi]
AB  - OBJECTIVES: The present study aimed to identify optimal inflammatory biomarkers 
      involved in cardiorenal risk in response to major lifestyle factors. METHODS: One 
      hundred and twenty-nine adults aged 35-77 years participated voluntarily from 
      2017 to 2019 (Cordoba, Argentina) in a cross-sectional study to collect 
      sociodemographic, clinical, and lifestyle data. Blood biomarkers (different 
      cytokines, monocyte chemoattractant protein-1 [MCP-1], and high-sensitivity 
      C-reactive protein [hs-CRP]) were measured using standard methods and then 
      evaluated by principal component analysis and structural equation modeling (SEM) 
      according to Mediterranean diet adherence, physical activity level, and waist 
      circumference, while cardiorenal risk involved blood diastolic pressure, 
      HDL-cholesterol, triacylglycerols, creatinine, and glycosylated hemoglobin. 
      RESULTS: A principal component included TNF-alpha (tumor necrosis factor-alpha), IL-8 
      (interleukin-8), IL-6 (interleukin-6), hs-CRP, and MCP-1, with absolute rotated 
      factor loadings >0.10. SEM showed that IL-6 (beta=0.38, 95 % IC=0.08-0.68), hs-CRP 
      (beta=0.33, 95 % IC=0.17-0.48), and TNF-alpha (beta=0.22, 95 % IC=0.11-0.32) were the 
      mediators that better explained an inflammatory profile positively related to 
      waist circumference (beta=0.77, 95 % IC=0.61-0.94). Moreover, this profile was 
      associated with an increased cardiorenal risk (beta=0.78, 95 % IC=0.61-0.94), which 
      was well-defined by the variable used. CONCLUSIONS: Immune mediators are key 
      elements in profiling the cardiorenal risk associated with lifestyle factors, for 
      which the combination of hs-CRP, IL-6, and TNF-alpha has emerged as a robust 
      indicator. This work reaffirms the need for biomarker optimization for early 
      diagnosis and risk assessment.
CI  - (c) 2023 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Marchiori, Georgina Noel
AU  - Marchiori GN
AUID- ORCID: 0000-0001-8633-9598
AD  - Universidad Nacional de Cordoba, Facultad de Ciencias Medicas, Escuela de 
      Nutricion, Centro de Investigaciones en Nutricion Humana (CenINH), Cordoba, 
      Argentina.
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, INICSA, 
      Cordoba, Argentina.
FAU - Defago, Maria Daniela
AU  - Defago MD
AUID- ORCID: 0000-0002-8878-3067
AD  - Universidad Nacional de Cordoba, Facultad de Ciencias Medicas, Escuela de 
      Nutricion, Centro de Investigaciones en Nutricion Humana (CenINH), Cordoba, 
      Argentina.
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, INICSA, 
      Cordoba, Argentina.
FAU - Baraquet, Maria Lucia
AU  - Baraquet ML
AUID- ORCID: 0000-0002-7730-0816
AD  - Universidad Nacional de Cordoba, Facultad de Ciencias Medicas, Escuela de 
      Nutricion, Centro de Investigaciones en Nutricion Humana (CenINH), Cordoba, 
      Argentina.
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, INICSA, 
      Cordoba, Argentina.
FAU - Del Rosso, Sebastian
AU  - Del Rosso S
AUID- ORCID: 0000-0003-2572-5887
AD  - Universidad Nacional de Cordoba, Facultad de Ciencias Quimicas, Centro de 
      Investigaciones en Bioquimica Clinica e Inmunologia (CIBICI-CONICET), Cordoba, 
      Argentina.
FAU - Perovic, Nilda Raquel
AU  - Perovic NR
AUID- ORCID: 0000-0003-4264-2610
AD  - Universidad Nacional de Cordoba, Facultad de Ciencias Medicas, Escuela de 
      Nutricion, Centro de Investigaciones en Nutricion Humana (CenINH), Cordoba, 
      Argentina.
FAU - Soria, Elio Andres
AU  - Soria EA
AUID- ORCID: 0000-0003-2373-2493
AD  - Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, INICSA, 
      Cordoba, Argentina.
AD  - Universidad Nacional de Cordoba, Facultad de Ciencias Medicas, Catedra de 
      Biologia Celular, Histologia y Embriologia, Instituto de Biologia Celular, 
      Cordoba, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20240101
PL  - Germany
TA  - Diagnosis (Berl)
JT  - Diagnosis (Berlin, Germany)
JID - 101654734
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Biomarkers
MH  - *C-Reactive Protein/analysis
MH  - Cross-Sectional Studies
MH  - *Interleukin-6
MH  - Tumor Necrosis Factor-alpha
MH  - Middle Aged
MH  - Aged
OTO - NOTNLM
OT  - Cardio-renal syndrome
OT  - cardiovascular system
OT  - clinical laboratory techniques
OT  - inflammation mediators
OT  - kidney
OT  - latent class analysis
EDAT- 2023/12/28 18:42
MHDA- 2024/02/20 11:50
CRDT- 2023/12/28 15:17
PHST- 2023/11/07 00:00 [received]
PHST- 2023/12/07 00:00 [accepted]
PHST- 2024/02/20 11:50 [medline]
PHST- 2023/12/28 18:42 [pubmed]
PHST- 2023/12/28 15:17 [entrez]
AID - dx-2023-0159 [pii]
AID - 10.1515/dx-2023-0159 [doi]
PST - epublish
SO  - Diagnosis (Berl). 2024 Jan 1;11(1):82-90. doi: 10.1515/dx-2023-0159. eCollection 
      2024 Feb 1.