PMID- 38154977
OWN - NLM
STAT- MEDLINE
DCOM- 20240101
LR  - 20240106
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 62
IP  - 1
DP  - 2024 Jan 2
TI  - [Clinical characteristics and prognosis of 28 cases of infant acute lymphoblastic 
      leukemia].
PG  - 49-54
LID - 10.3760/cma.j.cn112140-20230720-00020 [doi]
AB  - Objective: To analyze the clinical characteristics and prognosis of patients with 
      infant acute lymphoblastic leukemia (IALL). Methods: A retrospective cohort 
      study.Clinical data, treatment and prognosis of 28 cases of IALL who have been 
      treated at Beijing Children's Hospital, Capital Medical University and Baoding 
      Children's Hospital from October 2013 to May 2023 were analyzed retrospectively. 
      Based on the results of fluorescence in situ hybridization (FISH), all patients 
      were divided into KMT2A gene rearrangement (KMT2A-R) positive group and KMT2A-R 
      negative group. The prognosis of two groups were compared. Kaplan-Meier method 
      and Log-Rank test were used to analyze the survival of the patients. Results: 
      Among 28 cases of IALL, there were 10 males and 18 females, with the onset age of 
      10.9 (9.4,11.8) months. In terms of immune classification, 25 cases were B-ALL 
      (89%), while the remaining 3 cases were T-ALL (11%). Most infant B-ALL showed 
      pro-B lymphocyte phenotype (16/25,64%). A total of 22 cases (79%) obtained 
      chromosome karyotype results, of which 7 were normal karyotypes, no complex 
      karyotypes and 15 were abnormal karyotypes were found. Among abnormal karyotypes, 
      there were 4 cases of t (9; 11), 2 cases of t (4; 11), 2 cases of t (11; 19), 1 
      case of t (1; 11) and 6 cases of other abnormal karyotypes. A total of 19 cases 
      (68%) were positive for KMT2A-R detected by FISH. The KMT2A fusion gene was 
      detected by real-time PCR in 16 cases (57%). A total of 24 patients completed 
      standardized induction chemotherapy and were able to undergo efficacy evaluation, 
      23 cases (96%) achieved complete remission through induction chemotherapy, 4 
      cases (17%) died of relapse. The 5-year event free survival rate (EFS) was 
      (46+/-13)%, and the 5-year overall survival rate (OS) was (73+/-10)%.The survival 
      time was 31.3 (3.3, 62.5) months. There was no significant statistical difference 
      in 5-year EFS ((46+/-14)% vs. (61+/-18)%) and 5-year OS ((64+/-13)% vs. (86+/-13)%) 
      between the KMT2A-R positive group (15 cases) and the KMT2A-R negative group (9 
      cases) (chi(2)=1.88, 1.47, P=0.170, 0.224). Conclusions: Most IALL patients were 
      accompanied by KMT2A-R. They had poor tolerance to traditional chemotherapy, the 
      relapse rate during treatment was high and the prognosis was poor.
FAU - Shi, Y
AU  - Shi Y
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Lu, Y
AU  - Lu Y
AD  - Hematology Oncology Center, Baoding Children's Hospital,Baoding Key Laboratory of 
      Precision Medicine for Pediatric Hematology Oncology, Hematology Oncology Center 
      of National Center for Children's Health in Baoding, Baoding 071027, China.
FAU - Zhang, R D
AU  - Zhang RD
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Zhang, Y Y
AU  - Zhang YY
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Lin, W
AU  - Lin W
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Yu, J J
AU  - Yu JJ
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Wu, Y
AU  - Wu Y
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Fan, J
AU  - Fan J
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Qi, P J
AU  - Qi PJ
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Huang, P L
AU  - Huang PL
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
FAU - Cai, L X
AU  - Cai LX
AD  - Hematology Oncology Center, Baoding Children's Hospital,Baoding Key Laboratory of 
      Precision Medicine for Pediatric Hematology Oncology, Hematology Oncology Center 
      of National Center for Children's Health in Baoding, Baoding 071027, China.
FAU - Huang, Q
AU  - Huang Q
AD  - Hematology Oncology Center, Baoding Children's Hospital,Baoding Key Laboratory of 
      Precision Medicine for Pediatric Hematology Oncology, Hematology Oncology Center 
      of National Center for Children's Health in Baoding, Baoding 071027, China.
FAU - Zhang, P
AU  - Zhang P
AD  - Hematology Oncology Center, Baoding Children's Hospital,Baoding Key Laboratory of 
      Precision Medicine for Pediatric Hematology Oncology, Hematology Oncology Center 
      of National Center for Children's Health in Baoding, Baoding 071027, China.
FAU - Sun, Y M
AU  - Sun YM
AD  - Hematology Oncology Center, Baoding Children's Hospital,Baoding Key Laboratory of 
      Precision Medicine for Pediatric Hematology Oncology, Hematology Oncology Center 
      of National Center for Children's Health in Baoding, Baoding 071027, China.
FAU - Liu, Y
AU  - Liu Y
AD  - Hematology Oncology Center, Baoding Children's Hospital,Baoding Key Laboratory of 
      Precision Medicine for Pediatric Hematology Oncology, Hematology Oncology Center 
      of National Center for Children's Health in Baoding, Baoding 071027, China.
FAU - Zheng, H Y
AU  - Zheng HY
AD  - Hematology Center, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing Key Laboratory of Pediatric 
      Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, 
      National Key Discipline of Pediatrics, Key Laboratory of Major Diseases in 
      Children, Ministry of Education, Beijing 100045, China.
LA  - chi
GR  - 82070154/National Natural Science Foundation of China/
GR  - 7222056/Beijing Municipal Natural Science Foundation/
GR  - 2022-1-2091/Capital's Funds for Health Improvement and Research/
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
SB  - IM
MH  - Male
MH  - Child
MH  - Infant
MH  - Female
MH  - Humans
MH  - Retrospective Studies
MH  - In Situ Hybridization, Fluorescence
MH  - Prognosis
MH  - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/genetics/therapy
MH  - Abnormal Karyotype
MH  - Recurrence
EDAT- 2023/12/29 00:42
MHDA- 2024/01/02 11:45
CRDT- 2023/12/28 21:30
PHST- 2024/01/02 11:45 [medline]
PHST- 2023/12/29 00:42 [pubmed]
PHST- 2023/12/28 21:30 [entrez]
AID - 10.3760/cma.j.cn112140-20230720-00020 [doi]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2024 Jan 2;62(1):49-54. doi: 
      10.3760/cma.j.cn112140-20230720-00020.