PMID- 38155466
OWN - NLM
STAT- MEDLINE
DCOM- 20240509
LR  - 20240509
IS  - 1876-1038 (Electronic)
IS  - 1574-8871 (Linking)
VI  - 19
IP  - 1
DP  - 2024
TI  - Role of Complement-dependent Cytotoxicity Crossmatch and HLA Typing in Solid 
      Organ Transplant.
PG  - 34-52
LID - 10.2174/0115748871266738231218145616 [doi]
AB  - BACKGROUND: Solid organ transplantation is a life-saving medical operation that 
      has progressed greatly because of developments in diagnostic tools and 
      histocompatibility tests. Crossmatching for complement-dependent cytotoxicity 
      (CDC) and human leukocyte antigen (HLA) typing are two important methods for 
      checking graft compatibility and reducing the risk of graft rejection. HLA typing 
      and CDC crossmatching are critical in kidney, heart, lung, liver, pancreas, 
      intestine, and multi-organ transplantation. METHODS: A systematic literature 
      search was conducted on the internet, using PubMed, Scopus, and Google Scholar 
      databases, to identify peer-reviewed publications about solid organ transplants, 
      HLA typing, and CDC crossmatching. CONCLUSION: Recent advances in HLA typing have 
      allowed for high-resolution evaluation, epitope matching, and personalized 
      therapy methods. Genomic profiling, next-generation sequencing, and artificial 
      intelligence have improved HLA typing precision, resulting in better patient 
      outcomes. Artificial intelligence (AI) driven virtual crossmatching and 
      predictive algorithms have eliminated the requirement for physical crossmatching 
      in the context of CDC crossmatching, boosting organ allocation and transplant 
      efficiency. This review elaborates on the importance of HLA typing and CDC 
      crossmatching in solid organ transplantation.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Tiwari, Arpit
AU  - Tiwari A
AD  - Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, 
      Lucknow, Uttar Pradesh, India.
FAU - Mukherjee, Sayali
AU  - Mukherjee S
AD  - Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, 
      Lucknow, Uttar Pradesh, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Rev Recent Clin Trials
JT  - Reviews on recent clinical trials
JID - 101270873
RN  - 0 (HLA Antigens)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Humans
MH  - *Histocompatibility Testing/methods
MH  - *Organ Transplantation
MH  - Graft Rejection/immunology/prevention & control
MH  - HLA Antigens/immunology/genetics
MH  - Complement System Proteins
OTO - NOTNLM
OT  - CDC crossmatching
OT  - HLA
OT  - Solid organ
OT  - artificial intelligence
OT  - bone marrow.
OT  - transplantation
EDAT- 2023/12/29 06:43
MHDA- 2024/05/09 06:42
CRDT- 2023/12/29 01:13
PHST- 2023/07/05 00:00 [received]
PHST- 2023/11/10 00:00 [revised]
PHST- 2023/11/10 00:00 [accepted]
PHST- 2024/05/09 06:42 [medline]
PHST- 2023/12/29 06:43 [pubmed]
PHST- 2023/12/29 01:13 [entrez]
AID - RRCT-EPUB-136833 [pii]
AID - 10.2174/0115748871266738231218145616 [doi]
PST - ppublish
SO  - Rev Recent Clin Trials. 2024;19(1):34-52. doi: 
      10.2174/0115748871266738231218145616.