PMID- 38158418
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 281
IP  - 3
DP  - 2024 Mar
TI  - Chemoradiotherapy vs radiotherapy for non-surgical locally advanced laryngeal 
      squamous cell carcinoma patients: a propensity score-matched study and practical 
      nomogram construction.
PG  - 1449-1456
LID - 10.1007/s00405-023-08360-8 [doi]
AB  - OBJECTIVE: To compare the cancer-specific survival (CSS) among patients with 
      locally advanced laryngeal squamous cell carcinoma (LSCC) receiving 
      chemoradiotherapy (CRT) and radiotherapy (RT) treatment, as well as to establish 
      a prognostic nomogram for survival prediction in patients receiving CRT. METHOD: 
      Using data from the Surveillance, Epidemiology, and End Results (SEER) database, 
      patients with laryngeal cancer were identified between 2010 and 2015, with 
      follow-up up to 2018. Propensity score matching (PSM) was performed to minimize 
      disproportionate distributions of the potential confounding. Cox regression 
      models were used to evaluate the CSS of two treatment groups. A prognostic 
      nomogram for patients receiving CRT was then developed and evaluated. RESULTS: 
      Totally 1085 non-surgical patients with locally advanced LSCC were included in 
      this study (median [IQR] age, 62 [55-69] years; 829 [76.41%] males), of which 913 
      receiving CRT and 172 receiving RT. After PSM, significantly improved CSS was 
      observed in locally advanced LSCC patients receiving CRT when compared to RT (HR: 
      0.62 [95% CI 0.42-0.92]; P = 0.014). Then, in the group of 639 locally advanced 
      LSCC patients receiving CRT, a prognostic nomogram based on age, tumor size, N 
      category, and marital status were developed and validated, of which the 
      predictive performance was superior to that of TNM staging system (7th edition). 
      CONCLUSION: CSS shows a statistically significant improvement in locally advanced 
      LSCC patients who receipt of CRT when compared with RT. Furthermore, a prognostic 
      nomogram for locally advanced LSCC patients receiving CRT was established, which 
      shows a good calibration and identification accuracy.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhang, Yuan
AU  - Zhang Y
AUID- ORCID: 0009-0007-0025-179X
AD  - Department of Otolaryngology-Head and Neck Surgery, West China Hospital of 
      Sichuan University, Chengdu, China.
AD  - Department of Audiology, Guizhou Provincial People's Hospital, Guiyang, China.
FAU - Wang, Zhipeng
AU  - Wang Z
AD  - Department of Audiology, Guizhou Provincial People's Hospital, Guiyang, China.
FAU - Zheng, Yun
AU  - Zheng Y
AUID- ORCID: 0000-0002-0399-6064
AD  - Department of Otolaryngology-Head and Neck Surgery, West China Hospital of 
      Sichuan University, Chengdu, China. 1141679315@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20231229
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Female
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - *Nomograms
MH  - Propensity Score
MH  - Prognosis
MH  - Chemoradiotherapy
MH  - *Head and Neck Neoplasms
OTO - NOTNLM
OT  - Cancer-specific survival
OT  - Laryngeal squamous cell carcinoma
OT  - Nomogram
OT  - Propensity score matching
EDAT- 2024/01/02 11:43
MHDA- 2024/02/10 22:54
CRDT- 2023/12/29 23:18
PHST- 2023/10/10 00:00 [received]
PHST- 2023/11/14 00:00 [accepted]
PHST- 2024/02/10 22:54 [medline]
PHST- 2024/01/02 11:43 [pubmed]
PHST- 2023/12/29 23:18 [entrez]
AID - 10.1007/s00405-023-08360-8 [pii]
AID - 10.1007/s00405-023-08360-8 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2024 Mar;281(3):1449-1456. doi: 
      10.1007/s00405-023-08360-8. Epub 2023 Dec 29.