PMID- 38158644
OWN - NLM
STAT- Publisher
LR  - 20231230
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
DP  - 2023 Dec 29
TI  - Diabetic neuropathy: A NRF2 disease?
LID - 10.1111/1753-0407.13524 [doi]
AB  - The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has 
      multifarious action with its target genes having redox-regulating functions and 
      being involved in inflammation control, proteostasis, autophagy, and metabolic 
      pathways. Therefore, the genes controlled by NRF2 are involved in the 
      pathogenesis of myriad diseases, such as cardiovascular diseases, metabolic 
      syndrome, neurodegenerative diseases, autoimmune disorders, and cancer. Amidst 
      this large array of diseases, diabetic neuropathy (DN) occurs in half of patients 
      diagnosed with diabetes and appears as an injury inflicted upon peripheral and 
      autonomic nervous systems. As a complex effector factor, NRF2 has entered the 
      spotlight during the search of new biomarkers and/or new therapy targets in DN. 
      Due to the growing attention for NRF2 as a modulating factor in several diseases, 
      including DN, this paper aims to update the recently discovered regulatory 
      pathways of NRF2 in oxidative stress, inflammation and immunity. It presents the 
      animal models that further facilitated the human studies in regard to NRF2 
      modulation and the possibilities of using NRF2 as DN biomarker and/or as target 
      therapy.
CI  - (c) 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Neagu, Monica
AU  - Neagu M
AD  - Immunology Department, Victor Babes National Institute of Pathology, Bucharest, 
      Romania.
AD  - Pathology Department, Colentina Clinical Hospital, Bucharest, Romania.
AD  - Doctoral School, Faculty of Biology, University of Bucharest, Bucharest, Romania.
FAU - Constantin, Carolina
AU  - Constantin C
AUID- ORCID: 0000-0002-2870-5497
AD  - Immunology Department, Victor Babes National Institute of Pathology, Bucharest, 
      Romania.
AD  - Pathology Department, Colentina Clinical Hospital, Bucharest, Romania.
FAU - Surcel, Mihaela
AU  - Surcel M
AD  - Immunology Department, Victor Babes National Institute of Pathology, Bucharest, 
      Romania.
FAU - Munteanu, Adriana
AU  - Munteanu A
AD  - Immunology Department, Victor Babes National Institute of Pathology, Bucharest, 
      Romania.
FAU - Scheau, Cristian
AU  - Scheau C
AD  - Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 
      Bucharest, Romania.
FAU - Savulescu-Fiedler, Ilinca
AU  - Savulescu-Fiedler I
AD  - Department of Internal Medicine - Coltea Clinical Hospital, "Carol Davila" 
      University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Caruntu, Constantin
AU  - Caruntu C
AD  - Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 
      Bucharest, Romania.
AD  - Department of Dermatology, "Prof. N.C. Paulescu" National Institute of Diabetes, 
      Nutrition and Metabolic Diseases, Bucharest, Romania.
LA  - eng
GR  - PN-III-P2-2.1-PED-2021-2243/UEFISCDI/
GR  - 31PFE/30.12.2021/UEFISCDI/
GR  - Romanian Ministry of Research, Innovation, and Digitization/
GR  - III/
PT  - Journal Article
PT  - Review
DEP - 20231229
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
OTO - NOTNLM
OT  - NRF2
OT  - biomarker
OT  - diabetic neuropathy
OT  - inflammation
OT  - therapy target
EDAT- 2024/01/02 11:45
MHDA- 2024/01/02 11:45
CRDT- 2023/12/30 01:13
PHST- 2023/11/10 00:00 [revised]
PHST- 2023/07/24 00:00 [received]
PHST- 2023/12/06 00:00 [accepted]
PHST- 2024/01/02 11:45 [medline]
PHST- 2024/01/02 11:45 [pubmed]
PHST- 2023/12/30 01:13 [entrez]
AID - 10.1111/1753-0407.13524 [doi]
PST - aheadofprint
SO  - J Diabetes. 2023 Dec 29. doi: 10.1111/1753-0407.13524.