PMID- 38159411
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240201
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 695
DP  - 2024 Feb 5
TI  - The role of retinal glial cells and related factors in macular edema.
PG  - 149415
LID - S0006-291X(23)01509-7 [pii]
LID - 10.1016/j.bbrc.2023.149415 [doi]
AB  - Macular edema (ME) has emerged as a leading cause of visual impairment, 
      representing a critical clinical manifestation and complication associated with 
      many eye diseases. In the occurrence and development of ME, retinal glial cells 
      like Muller cells and microglial cells play vital roles. Moreover, growth factor 
      and cytokines associated with them, such as vascular endothelial growth factor 
      (VEGF), pigment epithelium-derived factor (PEDF), hypoxia-inducible factor-1alpha 
      (HIF-1alpha), angiopoietin-like protein 4 (ANGPTL4), interleukin-6(IL-6), 
      interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), prostaglandin, 
      etc., also take part in the pathogenesis of ME. Changes in these cytokines can 
      lead to retinal angiogenesis, increased vascular permeability, blood-retinal 
      barrier (BRB) breakdown, and fluid leakage, further causing ME to occur or 
      deteriorate. Research on the role of retinal glial cells and related cytokines in 
      ME will provide new therapeutic directions and effective remedies. This article 
      is a literature review on the role of Muller cells, microglial cells and related 
      factors in ME pathogenesis.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 
      China. Electronic address: 921185866@qq.com.
FAU - Qi, Shounan
AU  - Qi S
AD  - Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 
      China. Electronic address: qisn@jlu.edu.cn.
FAU - You, Jiaxin
AU  - You J
AD  - Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 
      China. Electronic address: 1027956548@qq.com.
FAU - Wang, Chenguang
AU  - Wang C
AD  - Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 
      China. Electronic address: wcg@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231223
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - *Macular Edema
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - Retina/metabolism
MH  - Neuroglia/metabolism
MH  - Cytokines/metabolism
OTO - NOTNLM
OT  - Cytokine
OT  - Macular edema
OT  - Microglial cells
OT  - Muller cells
COIS- Declaration of competing interest The authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest. Qi Zhang, Shounan Qi, Jiaxin 
      You and Chenguang Wang declare that they have no conflict of interest.
EDAT- 2024/01/02 11:44
MHDA- 2024/01/22 06:41
CRDT- 2023/12/30 18:05
PHST- 2023/10/31 00:00 [received]
PHST- 2023/12/09 00:00 [revised]
PHST- 2023/12/19 00:00 [accepted]
PHST- 2024/01/22 06:41 [medline]
PHST- 2024/01/02 11:44 [pubmed]
PHST- 2023/12/30 18:05 [entrez]
AID - S0006-291X(23)01509-7 [pii]
AID - 10.1016/j.bbrc.2023.149415 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2024 Feb 5;695:149415. doi: 
      10.1016/j.bbrc.2023.149415. Epub 2023 Dec 23.