PMID- 38161023
OWN - NLM
STAT- MEDLINE
DCOM- 20240208
LR  - 20240208
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 258
IP  - Pt 2
DP  - 2024 Feb
TI  - PDGF-AA loaded photo-crosslinked chitosan-based hydrogel for promoting wound 
      healing.
PG  - 129091
LID - S0141-8130(23)05990-1 [pii]
LID - 10.1016/j.ijbiomac.2023.129091 [doi]
AB  - Chitosan-based hydrogels are considered to be ideal materials for promoting wound 
      healing due to their nontoxic, biodegradable, and biocompatible properties. 
      However, the weak mechanical strength, hemostatic properties, and adhesive 
      properties of chitosan hydrogels limit their potential applications. In this 
      study, we synthesized methacrylimide-chitosan (MAC)-4-arm polyethylene glycol 
      (PEG)-dopamine (DMA) (MAC-PEG-DMA) hybrid hydrogels containing A-chain homodimers 
      of platelet-derived growth factor (PDGF-AA) through one-pot photo-crosslinking. 
      The resulting hydrogel exhibited improved mechanical strength and hemostatic 
      properties as demonstrated by both in vitro blood clotting assay and rat liver 
      hemorrhage assay. Furthermore, The PDGF-AA loaded hydrogel was also able to 
      accelerate cell migration and proliferation. Data from skin wounds treated with 
      this hybrid hydrogel showed faster wound closure and collagen maturation. 
      Therefore, MAC-PEG-DMA (PDGF-AA) has great potential as a dressing to promote 
      wound healing.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Cai, Zhuangzhuang
AU  - Cai Z
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
FAU - Mo, Zhendong
AU  - Mo Z
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
FAU - Zhou, Qing
AU  - Zhou Q
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
FAU - Zhou, Xujie
AU  - Zhou X
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
FAU - Huang, Feng
AU  - Huang F
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
FAU - Jiang, Jiaqi
AU  - Jiang J
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
FAU - Li, Hang
AU  - Li H
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China. 
      Electronic address: hangli@jnu.edu.cn.
FAU - Tang, Shunqing
AU  - Tang S
AD  - Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, 
      Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China. 
      Electronic address: tshunqt@jnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231230
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 9012-76-4 (Chitosan)
RN  - 0 (poly(ethylene glycol)-dimethacrylate)
RN  - 0 (Hydrogels)
RN  - 0 (platelet-derived growth factor A)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Hemostatics)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Methacrylates)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Chitosan
MH  - Hydrogels
MH  - Wound Healing
MH  - Platelet-Derived Growth Factor
MH  - *Hemostatics
MH  - Anti-Bacterial Agents
MH  - *Methacrylates
MH  - *Polyethylene Glycols
OTO - NOTNLM
OT  - Adhesive
OT  - Chitosan
OT  - Hemostasis
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/01/02 11:44
MHDA- 2024/02/08 06:42
CRDT- 2023/12/31 19:18
PHST- 2023/06/15 00:00 [received]
PHST- 2023/12/20 00:00 [revised]
PHST- 2023/12/26 00:00 [accepted]
PHST- 2024/02/08 06:42 [medline]
PHST- 2024/01/02 11:44 [pubmed]
PHST- 2023/12/31 19:18 [entrez]
AID - S0141-8130(23)05990-1 [pii]
AID - 10.1016/j.ijbiomac.2023.129091 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2024 Feb;258(Pt 2):129091. doi: 
      10.1016/j.ijbiomac.2023.129091. Epub 2023 Dec 30.