PMID- 38162517
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240103
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - The mediatory role of inflammatory markers on the relationship between the NOVA 
      classification system and obesity phenotypes among obese and overweight adult 
      women: a cross-sectional study.
PG  - 1226162
LID - 10.3389/fnut.2023.1226162 [doi]
LID - 1226162
AB  - BACKGROUND: Diet and inflammation both play important roles in the occurrence of 
      obesity. We aimed to investigate the role of inflammation in the development of 
      both metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) 
      individuals. METHODS: This cross-sectional study included 221 overweight and 
      obese women aged 18-56 years. The study assessed the metabolic health phenotypes 
      of the participants using the Karelis criterion score. Additionally, dietary 
      intakes were evaluated using a 147-item semi-quantitative questionnaire and the 
      NOVA classification system (comprising 37 food groups and beverages). The study 
      also collected and analyzed the blood parameters, as well as biochemical and 
      anthropometric indices, for all participants. RESULTS: Among the women included 
      in the study, 22.9% had MHO phenotypes but 77.1% had MUHO phenotypes. A 
      significant association between the third quartile of the NOVA classification 
      system and the increased likelihood of having the MUHO phenotype was observed 
      (OR = 1.40, 95% CI = 1.09-4.92, p = 0.04). Regarding the potential role of 
      inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) (p = 0.84), 
      transforming growth factor-beta (TGF-beta) (p = 0.50), monocyte chemoattractant 
      protein-1 (MCP-1) (p = 0.49), plasminogen activator inhibitor-1 (PAI-1) 
      (p = 0.97), and homeostatic model assessment for insulin resistance (HOMA-IR) 
      (p = 0.92) were found to be mediators. CONCLUSION: We observed a significant 
      positive association between ultra-processed food (UPF) consumption and the MUHO 
      phenotype in overweight and obese women. This association appeared to be mediated 
      by some inflammatory markers, such as hs-CRP, TGF-beta, MCP-1, PAI-1, and HOMA-IR. 
      Additional studies are needed to validate these findings.
CI  - Copyright (c) 2023 Hajmir, Shiraseb, Hosseininasab, Aali, Hosseini and Mirzaei.
FAU - Hajmir, Mahya Mehri
AU  - Hajmir MM
AD  - Students' Scientific Center, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Shiraseb, Farideh
AU  - Shiraseb F
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Hosseininasab, Dorsa
AU  - Hosseininasab D
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Aali, Yasaman
AU  - Aali Y
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Hosseini, Shabnam
AU  - Hosseini S
AD  - School of Human Nutrition, McGill University, Quebec, QC, Canada.
FAU - Mirzaei, Khadijeh
AU  - Mirzaei K
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
AD  - Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10754978
OTO - NOTNLM
OT  - NOVA classification system
OT  - inflammatory markers
OT  - metabolic healthy and unhealthy women
OT  - phenotypes
OT  - ultra-processed foods
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/02 11:42
MHDA- 2024/01/02 11:43
PMCR- 2023/01/01
CRDT- 2024/01/01 04:23
PHST- 2023/05/27 00:00 [received]
PHST- 2023/11/21 00:00 [accepted]
PHST- 2024/01/02 11:43 [medline]
PHST- 2024/01/02 11:42 [pubmed]
PHST- 2024/01/01 04:23 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1226162 [doi]
PST - epublish
SO  - Front Nutr. 2023 Dec 11;10:1226162. doi: 10.3389/fnut.2023.1226162. eCollection 
      2023.