PMID- 38162651
OWN - NLM
STAT- MEDLINE
DCOM- 20240103
LR  - 20240329
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Causal relationship between asthma and ulcerative colitis and the mediating role 
      of interleukin-18: a bidirectional Mendelian study and mediation analysis.
PG  - 1293511
LID - 10.3389/fimmu.2023.1293511 [doi]
LID - 1293511
AB  - OBJECTIVE: Numerous observational investigations have documented a correlation 
      between asthma and ulcerative colitis(UC). In this Mendelian Randomization (MR) 
      study, we utilized extensive summary data from Genome-Wide Association Studies 
      (GWAS) to further estimate the association between adult-onset asthma and the 
      risk of UC, and to investigate the role of Interleukin-18 (IL-18) as a potential 
      mediator. MATERIALS AND METHODS: A two-step, two-sample MR study was conducted 
      through mediation analysis. For this study, we employed a two-sample MR analysis 
      using the inverse variance-weighted (IVW), weighted median, weighted mode, and 
      MR-Egger regression techniques. We utilized publicly accessible summary 
      statistics from a GWAS meta-analysis of adult-onset asthma in the UK Biobank 
      (n=327,253; cases=26,582; controls=300,671) as the exposure factor. The outcomes 
      were derived from GWAS data of individuals with European ancestry (n=26,405; 
      cases=6,687; controls=19,718). GWAS data for IL-18 were obtained from individuals 
      of European ancestry (n=9,785,222; cases=3,636; controls=9,781,586). RESULTS: The 
      MR analysis indicates that adult-onset asthma is associated with an increased 
      risk of UC, with an odds ratio (OR) of 1.019 (95% CI 1.001-1.045, P=0.006). 
      However, there is no strong evidence to suggest that UC significantly impacts the 
      risk of adult-onset asthma. IL-18 may act as a potential mediator in the causal 
      relationship between adult-onset asthma and UC, with a mediation proportion of 
      3.9% (95% CI, 0.6%-6.9%). CONCLUSION: In summary, our study established a causal 
      relationship between asthma and UC, in which IL-18 contributes to a small extent. 
      However, the primary factors underlying the influence of asthma on UC remain 
      unclear. Future research should focus on identifying other potential mediators. 
      In clinical practice, it is important to pay greater attention to intestinal 
      lesions in patients with asthma.
CI  - Copyright (c) 2023 Zou, Lu, Liao, Liu and Dai.
FAU - Zou, Xin
AU  - Zou X
AD  - Department of Gastroenterology, Ganzhou Municipal Hospital(Guangdong Provincial 
      People's Hospital Ganzhou Hospital), Ganzhou, Jiangxi, China.
FAU - Lu, Rui-Ling
AU  - Lu RL
AD  - Department of Gastroenterology, Ganzhou Municipal Hospital(Guangdong Provincial 
      People's Hospital Ganzhou Hospital), Ganzhou, Jiangxi, China.
AD  - Department of Rheumatology and Immunology, The Second Clinical Medical College, 
      Jinan University (Shenzhen People's Hospital), Shenzhen, Guangdong, China.
FAU - Liao, Bin
AU  - Liao B
AD  - Department of Gastroenterology, Ganzhou Municipal Hospital(Guangdong Provincial 
      People's Hospital Ganzhou Hospital), Ganzhou, Jiangxi, China.
FAU - Liu, Shi-Jie
AU  - Liu SJ
AD  - Department of Gastroenterology, Geriatric Center, National Regional Medical 
      Center, Guangdong Provincial People's Hospital Ganzhou Hospital, Ganzhou, 
      Jiangxi, China.
FAU - Dai, Shi-Xue
AU  - Dai SX
AD  - Department of Gastroenterology, Geriatric Center, National Regional Medical 
      Center, Guangdong Provincial People's Hospital Ganzhou Hospital, Ganzhou, 
      Jiangxi, China.
LA  - eng
PT  - Journal Article
DEP - 20231214
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Asthma/genetics
MH  - *Colitis, Ulcerative/genetics
MH  - Genome-Wide Association Study
MH  - *Interleukin-18/genetics
MH  - Mediation Analysis
MH  - Mendelian Randomization Analysis
PMC - PMC10757619
OTO - NOTNLM
OT  - Mendelian randomization
OT  - asthma
OT  - causal inference
OT  - interleukin-18
OT  - mediation
OT  - tool variables
OT  - ulcerative colitis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/02 11:45
MHDA- 2024/01/03 09:44
PMCR- 2023/01/01
CRDT- 2024/01/01 04:27
PHST- 2023/09/13 00:00 [received]
PHST- 2023/11/30 00:00 [accepted]
PHST- 2024/01/03 09:44 [medline]
PHST- 2024/01/02 11:45 [pubmed]
PHST- 2024/01/01 04:27 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1293511 [doi]
PST - epublish
SO  - Front Immunol. 2023 Dec 14;14:1293511. doi: 10.3389/fimmu.2023.1293511. 
      eCollection 2023.