PMID- 38163657
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240104
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 20
IP  - 12
DP  - 2023 Dec
TI  - Higher Fat-Related Body Composition Measurement and Lower Resting-State 
      Inter-Network Functional Connectivity of APOE epsilon4 Carrier in Mild Cognitive 
      Impairment Patients With Abeta Deposition.
PG  - 1177-1184
LID - 10.30773/pi.2023.0138 [doi]
AB  - OBJECTIVE: We aimed to evaluate the impact of interaction between APOE epsilon4 carrier 
      status and body composition measurements on intra- and inter-regional functional 
      connectivity (FC) in mild cognitive impairment (MCI) patients with Abeta deposition. 
      METHODS: MCI patients with and without APOE epsilon4 allele (carrier, n=86; 
      non-carrier, n=95) underwent neuropsychological battery, resting-state functional 
      magnetic resonance imaging scans, positron emission tomography scans with 
      [18F]flutemetamol, and bioelectrical impedance analysis for measuring body 
      composition. We employed a priori defined regions of interest to investigate the 
      intra- and inter-network FC profiles of default mode network (DMN), central 
      executive network (CEN), and salience network. RESULTS: There was a significant 
      interaction of APOE epsilon4 carrier status with body fat mass index, visceral fat 
      area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, 
      contributing higher fat-related body composition measurements in the APOE epsilon4 
      carrier with lower DMN-CEN FC. CONCLUSION: The present results highlight the 
      detrimental effect of APOE epsilon4 carrier status on the associations between the 
      fat-related body composition measurements and FC in the MCI patients with Abeta 
      accumulation.
FAU - Choi, In Hyeok
AU  - Choi IH
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Wang, Sheng-Min
AU  - Wang SM
AD  - Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Um, Yoo Hyun
AU  - Um YH
AD  - Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Lim, Hyun Kook
AU  - Lim HK
AD  - Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Lee, Chang Uk
AU  - Lee CU
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Kang, Dong Woo
AU  - Kang DW
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
LA  - eng
GR  - 2022R1I1A1A01053710/National Research Foundation of Korea/
GR  - Ministry of Education/
PT  - Journal Article
DEP - 20231218
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC10758323
OTO - NOTNLM
OT  - Apolipoprotein
OT  - Bioelectrical impedance
OT  - Body composition
OT  - Functional neuroimaging
OT  - Mild cognitive impairment
COIS- Conflicts of Interest Yoo Hyun Um and Hyun Kook Lim, a contributing editor of the 
      Psychiatry Investigation, were not involved in the editorial evaluation or 
      decision to publish this article. All remaining authors have declared no 
      conflicts of interest.
EDAT- 2024/01/02 11:43
MHDA- 2024/01/02 11:44
PMCR- 2023/12/01
CRDT- 2024/01/01 19:58
PHST- 2023/05/04 00:00 [received]
PHST- 2023/09/12 00:00 [accepted]
PHST- 2024/01/02 11:44 [medline]
PHST- 2024/01/02 11:43 [pubmed]
PHST- 2024/01/01 19:58 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - pi.2023.0138 [pii]
AID - pi-2023-0138 [pii]
AID - 10.30773/pi.2023.0138 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2023 Dec;20(12):1177-1184. doi: 10.30773/pi.2023.0138. Epub 
      2023 Dec 18.