PMID- 38164252
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240103
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 11
DP  - 2023
TI  - Evaluation of the in vitro antioxidant and antitumor activity of hydroalcoholic 
      extract from Jatropha mollissima leaves in Wistar rats.
PG  - 1283618
LID - 10.3389/fchem.2023.1283618 [doi]
LID - 1283618
AB  - Introduction: Despite modern sciences and advancements in new drugs or chemicals, 
      the new era now rushes natural remedies for various illnesses and diseases that 
      lead to end organ damage. In this study, we investigated Jatropha mollissima 
      ethanolic extract's effect against doxorubicin-induced cardiotoxicity and renal 
      toxicity. Methods: To determine phytochemicals, a phytochemical screening was 
      conducted. Various assays were used to measure the antioxidant activity, 
      including the DPPH (2,2-diphenylpicrylhydrazyl), SOD (superoxide dismutase), NO 
      (nitric oxide), and others. The antiproliferative effect of Jm was assessed by 
      MTT assay; morphological analysis was performed using an inverted and phase 
      contrast microscope, ultra morphological analysis of apoptosis with acridine 
      orange (AO)/propidium iodide (PI) staining. Results: It was seen that doxorubicin 
      caused elevated serum markers and abnormal changes in histological patterns. The 
      significant reduction in cardiac and renal marker levels seen in groups given 
      either 400 or 600 mg/kg of crude extract demonstrates that Jm has a protective 
      effect against doxorubicin-induced cardiotoxicity due to the presence of active 
      phytoconstituents having antioxidant potential. There is a dose-dependent 
      decrease in cell viability when using J. mollissima. Apoptosis was observed in 
      the treated cells. Conclusion: In conclusion, our research lends credence to the 
      idea that J. mollissima could be used for cancer management and have 
      cardioprotective and nephroprotective effects.
CI  - Copyright (c) 2023 Iqbal, Gu, Khan, Wang and Chen.
FAU - Iqbal, Muhammad Omer
AU  - Iqbal MO
AD  - College of Marine Science and Biological Engineering, Qingdao University of 
      Science and Technology, Qingdao, China.
AD  - Key Laboratory of Marine Drugs, The Ministry of Education, School of Medicine and 
      Pharmacy, Ocean University of China, Qingdao, China.
AD  - Fatima Tu Zahara Department of Life Sciences, Muhammad Institute of Medical and 
      Allied Sciences, Multan, Pakistan.
FAU - Gu, Yuchao
AU  - Gu Y
AD  - College of Marine Science and Biological Engineering, Qingdao University of 
      Science and Technology, Qingdao, China.
FAU - Khan, Imran Ahmad
AU  - Khan IA
AD  - Fatima Tu Zahara Department of Life Sciences, Muhammad Institute of Medical and 
      Allied Sciences, Multan, Pakistan.
AD  - Department of Pharmacy, MNS University of Agriculture, Multan, Pakistan.
FAU - Wang, Ruihong
AU  - Wang R
AD  - The Affiliated Qingdao Central Hospital of Qingdao University, Qingdao, China.
FAU - Chen, Jin
AU  - Chen J
AD  - College of Marine Science and Biological Engineering, Qingdao University of 
      Science and Technology, Qingdao, China.
LA  - eng
PT  - Journal Article
DEP - 20231218
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
PMC - PMC10757942
OTO - NOTNLM
OT  - Jatropha mollissima
OT  - anticancer
OT  - antioxidant
OT  - cardioprotective
OT  - doxorubicin
OT  - nephroprotective
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/02 11:44
MHDA- 2024/01/02 11:45
PMCR- 2023/01/01
CRDT- 2024/01/02 03:39
PHST- 2023/08/26 00:00 [received]
PHST- 2023/12/04 00:00 [accepted]
PHST- 2024/01/02 11:45 [medline]
PHST- 2024/01/02 11:44 [pubmed]
PHST- 2024/01/02 03:39 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 1283618 [pii]
AID - 10.3389/fchem.2023.1283618 [doi]
PST - epublish
SO  - Front Chem. 2023 Dec 18;11:1283618. doi: 10.3389/fchem.2023.1283618. eCollection 
      2023.